Evaluation of “Open Essence” odor-identification test card by application to healthy volunteers

Okutani, Fumino; Hirose, Kahori; Kobayashi, Taisuke; Kaba, Hideto; Hyodo, Masamitsu

doi:10.1016/j.anl.2012.02.007

Cited by 49 publications

(34 citation statements)

References 15 publications

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“…The mean age (37.5 years) of the 243 subjects assessed in the present study was younger than the mean age (50.0 years) of the 83 Japanese participants at the check-up previously assessed [7]. Okutani et al [11] have shown that all participants recognized the curry odorant of the Open Essence test in a cohort of young, healthy volunteers. Curry odor may be familiar for most Japanese people because curry is a very popular food in Japan, and it is possible that the curry odorant contains odors that intensely stimulate olfactory neurons.…”

Section: Discussioncontrasting

confidence: 53%

Combinations of two odorants of smell identification test for screening of olfactory impairment

et al. 2014

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Section: Discussioncontrasting

confidence: 53%

Combinations of two odorants of smell identification test for screening of olfactory impairment

et al. 2014

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“…These 12 odorants were the same as those used in the odor stick identification test for the Japanese (Daiichi Yakuhin Sangyo, Tokyo, Japan), which is a commonly used test kit for patients with olfactory disturbance . Significant correlations have been reported between Open Essence and odor stick identification test for the Japanese scores …”

Section: Methodsmentioning

confidence: 99%

Voxel‐based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment

et al. 2019

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Objective Brain iron accumulation has been proposed as one of the pathomechanisms in Parkinson's disease (PD). This study aimed to examine the whole‐brain pattern of iron accumulation associated with cognitive impairment in patients with PD using voxel‐based quantitative susceptibility mapping analysis. Methods We enrolled 24 patients with PD and mild cognitive impairment, 22 patients with PD and normal cognition, and 20 age‐matched healthy controls in this cross‐sectional study. All participants underwent global cognitive and physical assessments and brain MRI. Using a combined method of voxel‐based morphometry and quantitative susceptibility mapping, we compared the voxel‐wise magnetic susceptibility of the whole brain between the groups and analyzed its correlation with the cognitive and behavioral data. Results The PD and mild cognitive impairment group had lower Montreal Cognitive Assessment (MoCA) score than the PD and normal cognition and healthy control groups. There were no gray matter volumetric differences between the groups. In contrast, the voxel‐based quantitative susceptibility mapping analysis showed that the PD and mild cognitive impairment group had significantly higher quantitative susceptibility mapping values in the cuneus, precuneus, caudate head, fusiform gyrus, and orbitofrontal cortex than did the PD and normal cognition group. These quantitative susceptibility mapping values were negatively correlated with the MoCA scores in the PD patients (cuneus: r = −0.510, P < .001; caudate head: r = −0.458, P = 0.002). Conclusions This study suggests that cognitive impairment in PD is associated with cerebral iron burden and highlights the potential of quantitative susceptibility mapping as an auxiliary biomarker for early evaluation of cognitive decline in patients with PD. © 2019 International Parkinson and Movement Disorder Society

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“…There is a normal latency (7-8 s) and normal duration of sensation (1-2 min) of smell sensation with the derivative that is typically unknown by the subject and can be used to detect malingering. The Open Essence test is stick and card test similar to the UPSIT, though with odors confirmed as familiar to healthy Japanese subjects with normal olfaction [57][58][59].…”

Section: Olfactory Testingmentioning

confidence: 99%

Posttraumatic olfactory dysfunction

Coelho

Costanzo

2016

Auris Nasus Larynx

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Evaluation of “Open Essence” odor-identification test card by application to healthy volunteers

Cited by 49 publications

References 15 publications

Combinations of two odorants of smell identification test for screening of olfactory impairment

Combinations of two odorants of smell identification test for screening of olfactory impairment

Voxel‐based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment

Posttraumatic olfactory dysfunction

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