Evaluation of oxidant–antioxidant balance and total antioxidant capacity in urinary tract infection in children

Hassan, Fahima M; Elgazzar, Basim Abdelfattah; El-Helbawy, Mohamed G; Elhabashy, Manar H

doi:10.4103/mmj.mmj_273_19

Cited by 1 publication

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“…Another recent study investigated the serum levels of oxidative stress biomarkers such as malondialdehyde (MDA) and total antioxidant capacity (TAC) in children with culture-positive UTI. 50 Oxidant-antioxidant balance biomarkers (MDA and TAC) were quantified in their serum samples. Urine culture was performed to identify the causative organism of UTI.…”

Section: More Recent Novel Biomarkers In Urinary Tract Infection Diag...mentioning

confidence: 99%

“…It was concluded that the rise in serum MDA and reduction in serum TAC levels also implied an attenuation in the protective effects of antioxidants, given that low levels of reactive oxygen species are typically produced during tissue metabolism. 50 Table 1 summarises the potential indications of the established and more recent novel biomarkers. Beyond their utility in UTI diagnostics, 53 they have hitherto been found useful in various other diseases.…”

Section: More Recent Novel Biomarkers In Urinary Tract Infection Diag...mentioning

confidence: 99%

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Are Positive Urine Cultures Directly Correlated with Elevated Levels of Novel Biomarkers for Childhood Urinary Tract Infection?

Uwaezuoke

Odimegwu

Chikani

et al. 2022

EMJ Microbiol Infect Dis

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Urinary tract infection (UTI) in children is one of the most common bacterial infections that propels inappropriate antibiotic use. Long-term, potentially fatal complications can occur if not properly treated. Prompt investigation and appropriate treatment would prevent these complications. Although urine culture remains the gold standard investigation for UTI, its process is cumbersome and requires time (24–72 hours). Hence, there has been growing interest in the use of urinary biomarkers. However, some conventional urinary biomarkers detected on urinalysis have poor sensitivity values when used singly as a screening tool. Thus, the searchlight has shifted to the role of novel biomarkers in UTI diagnosis. This narrative review aimed to determine if elevated levels of these biomarkers directly correlate with positive urine cultures. A positive correlation may imply that these biomarkers could serve as novel UTI diagnostics and thus augment urine culture requests. Established and recent serum and urinary biomarkers show disparate predictive abilities for UTI and its related complications. Some have elevated differential levels in upper and lower UTI or febrile and non-febrile UTI. All studies that investigated these biomarkers established culture-positive UTI, highlighting a direct correlation between positive urine cultures and increased concentrations of the biomarkers in body fluids. Because certain uropathogens were less likely to be associated with pyuria, the sensitivities of some neutrophil-related novel biomarkers (such as urine neutrophil gelatinase-associated lipocalin and human neutrophil peptides 1–3) were reduced in cases of UTI caused by these bacteria. While levels of these novel biomarkers directly correlate with positive urine cultures, it appears that there is yet no standalone biomarker with the optimal sensitivity and specificity for UTI. Although these novel biomarkers are promising, translating their measurements into clinical practice with specific clinical utilities will take time. Novel methods interrogating high-throughput serum (and urine) metabolome data with positive urine cultures in a platform-agnostic manner (metabolome-wide approach) will help confirm and identify novel biomarkers that might capture specific aetiologic agents or shared pathways of related agents. The authors recommend that future research on UTI diagnostics should specifically focus on identifying highly sensitive and specific standalone novel biomarkers that can be easily applied as a point-of-care investigation.

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Section: More Recent Novel Biomarkers In Urinary Tract Infection Diag...mentioning

confidence: 99%

Section: More Recent Novel Biomarkers In Urinary Tract Infection Diag...mentioning

confidence: 99%

Are Positive Urine Cultures Directly Correlated with Elevated Levels of Novel Biomarkers for Childhood Urinary Tract Infection?

Uwaezuoke

Odimegwu

Chikani

et al. 2022

EMJ Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

Evaluation of oxidant–antioxidant balance and total antioxidant capacity in urinary tract infection in children

Cited by 1 publication

References 0 publications

Are Positive Urine Cultures Directly Correlated with Elevated Levels of Novel Biomarkers for Childhood Urinary Tract Infection?

Are Positive Urine Cultures Directly Correlated with Elevated Levels of Novel Biomarkers for Childhood Urinary Tract Infection?

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