Evaluation of Oxidant-antioxidant Status in Obese Children and Adolescents

Al-Dalaeen, Anfal; Al-Domi, Hayder

doi:10.3923/pjn.2016.942.947

Cited by 4 publications

(7 citation statements)

References 17 publications

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“…6 Higher MDA levels in obese subjects are also reported by researches conducted in various other regions of world including Jordan and Saudi Arabia that justified our results. 3,4 Present study also found higher levels of anti-oxidant SOD in obese subjects than non-obese subjects and was positively related with BMI. SOD is believed to be the first line of antioxidant defense system.…”

Section: Discussionsupporting

confidence: 70%

“…2 Growing evidences also indicate that the white adipose tissues in obese subjects are associated with excess generation of ROS including superoxide (O2 -) and H2O2, accompanied by augmented expression of NADPH oxidase and decline in anti-oxidative enzymes that are required to resist ROS mediated cellular damage. 3 If oxidation by ROS exceeds the antioxidants defense system, oxidative stress is generated. 10 We found significant higher levels of MDA in obese subjects and it was significantly associated with BMI, suggesting the presence of oxidative stress in these subjects.…”

Section: Discussionmentioning

confidence: 99%

“…2 Hyperlipidemia, hyperleptinemia and release of inflammatory cytokines from adipocytes are the contributing factors for over production of Reactive Oxygen Species (ROS) including Superoxide (O2 -) and Hydrogen Peroxide (H2O2) that causes oxidative stress, damage to DNA and RNA leading to cell death. 3 Moreover, oxidative stress is best reflected by products of lipid peroxidation Malondialdehyde (MAD). 4 In obese subjects accumulation of abdominal fat enhances lipid peroxidation and subsequent production of MDA due to excess release of pro-inflammatory cytokine interleukin-6 (IL6), Tumor Necrosis Factoralpha (TNF-α) and C Reactive Proteins (CRP).…”

Section: Introductionmentioning

confidence: 99%

“…4 In obese subjects accumulation of abdominal fat enhances lipid peroxidation and subsequent production of MDA due to excess release of pro-inflammatory cytokine interleukin-6 (IL6), Tumor Necrosis Factoralpha (TNF-α) and C Reactive Proteins (CRP). 3 These factors are responsible for activating the apoptotic cascade causing cell death and oxidative stress in obese subjects.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Oxidative Stress Markers’ Status in Obese Females Using Hormonal Contraceptives

Aitazaz¹,

Aurangzeb²,

Khan³

et al. 2020

JAFMDC

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Objective: To evaluate the variation in oxidative stress markers including superoxide dismutase (SOD), catalase and malondialdehyde (MDA) and to correlate it with obesity in females using contraceptives.Methodology: Comparative cross sectional study was project of University of Lahore (UOL).conducted in collaboration with Basic Health Unit Mudkey (periphery of Kasur) from January to December 2013. The study population comprised of 51 married females of age ranged 25 to 40 years. The study was approved by the Research Ethical Committee of UOL. Thirty one females using either combined oral contraceptive pills (COC) or progestin injections were enrolled for a period of 9 months, while 20 females not using any type of contraceptives were recruited as a control group. Weight in kg and height in meter were estimated by the standard protocol. Body Mass Index (BMI) was calculated by the formula; weight in kg /height in m2. Subjects having BMI greater than 25kg/m2 were categorized as obese. Stress markers were estimated from blood samples. SOD was assayed by nitroblue tetrazolium method by spectrophotometer. Catalase and Glutathione levels were also determined using spectrophotometer. MDA levels were measured by Thiobarbitoric acid assay reaction. with MDA. Statistical analysis was performed by SPSS20. Mean ± SD (standard deviation) was used for continuous variables; while frequency and percentages were used for estimation of categorical variables. Regression analysis was applied to elucidate association between obesity and the stress markers.Results: SOD and MDA levels were significantly higher in obese group as compared to non-obese group (p values = 0.02, 0.04). No significant differences was noted in obese and non- obese subjects with respect to catalase (p value= 0.35) and Glutathione (p value=0.9) concentrations. Regression analysis shows significant positive association of BMI with SOD (p value 0.006) and MDA (p value 0.000); however, catalase (p value 0.28) and Glutathione (p value 0.85) were not significantly associated with BMI.Conclusion: Oxidative stress in obese are due to higher MDA levels. SOD is positively associated with BMI; however catalase and glutathione are not affected by BMI.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Oxidative Stress Markers’ Status in Obese Females Using Hormonal Contraceptives

Aitazaz¹,

Aurangzeb²,

Khan³

et al. 2020

JAFMDC

View full text Add to dashboard Cite

show abstract

“…Although oxidative stress in obese pediatric populations has been well demonstrated, there has been discordance in terms of redox biomarkers. Higher erythrocyte GPx activity and GSH levels were noted in children with obesity than in their NW counterparts, in contrast to increased oxidative stress indicators in obese children, such as oxidized low-density lipoprotein, malondialdehyde, and advanced oxidation products 17 – 21 . Thus far, the relationship between ID states and antioxidant enzymes, including GPx, has been inconsistent and controversial 22 , 23 .…”

Section: Introductionmentioning

confidence: 82%

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Alkazemi

Rahman

Habra

2021

Sci Rep

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The reduced (GSH)-to-oxidized (GSSG) glutathione ratio represents a dynamic balance between oxidants and antioxidants. However, redox status in adolescents with obesity and anemia has not been investigated. This study investigated the association of erythrocyte GSH redox status (GSH, GSH:GSSG ratio, and glutathione peroxidase [GPx] activity) with anemia and adiposity in adolescents. This case–control study nested in a cross-sectional study enrolled 524 adolescents (268 boys; 256 girls). The prevalence of anemia in overweight and obesity (OWOB) was 5.2% in boys and 11.7% in girls. The GSH:GSSG ratio and GPx activity were significantly higher in girls than in boys (p < 0.001), in anemic than in non-anemic subjects (p < 0.001), and in OWOB than in normal-weight subjects (p < 0.001). Similarly, significantly higher GSH: GSSG level (p < 0.001) and GPx activity (p < 0.001) were found in subjects with 90th percentile waist circumference than in those with < 90th percentile. GPx and GSH:GSSG were positively associated with anemia after adjusting for age, sex, and body mass index (adjusted odds ratio, adjOR [95% confidence interval, CI] 2.18 [1.44–3.29]) or tertiles (adjOR [95% CI], T3 = 2.49 [1.03–6.01]). A similar association was noted for GSH and GPx. A compensatory increased redox defense mechanism exists in anemia and obesity among adolescents without metabolic disturbances.

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Nutritional status of selenium in overweight and obesity: A systematic review and meta-analysis

et al. 2022

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Evaluation of Oxidant-antioxidant Status in Obese Children and Adolescents

Cited by 4 publications

References 17 publications

Evaluation of Oxidative Stress Markers’ Status in Obese Females Using Hormonal Contraceptives

Evaluation of Oxidative Stress Markers’ Status in Obese Females Using Hormonal Contraceptives

Alterations in glutathione redox homeostasis among adolescents with obesity and anemia

Nutritional status of selenium in overweight and obesity: A systematic review and meta-analysis

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