Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents

Bagherzadeh, Farzaneh; Ebrahimi-Mameghani, Mehrangiz; Jafarabadi, Mohammad Asghari; Aslani, Zahra; Edalati, Sareh

doi:10.11648/j.ajbio.s.2015030202.11

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…The exist of oxidative stress is known to play an major role in DM and DM-related diseases such as dyslipidemia, hypertension and atherosclerosis [6,7]. Reactive oxygen species (ROS) can cause deletions of different sizes, insertions, DNA base damage and strand breaks [8,9]. Compared with other bases, guanine is most susceptible to oxidation by ROS [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

Gulbay,

Kaya

2023

Med-Science

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We aimed to see the effect of lipids on 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of DNA damage, and Interleukin-6 (IL-6), an inflammatory cytokine, in Diabetes Mellitus (DM) patients. Serum IL-6, and 8-OHdG levels were determined using kits based on the ELISA principle. The groups were different in terms of total cholesterol, LDL cholesterol and triglyceride. Group 2 (dyslipidemia positive DM positive) was significantly higher than the other groups. There was no statistical difference between group 1 (dyslipidemia negative DM positive) and the control group (p<0.001). 8-OHdG levels differ between groups. The level of 8-OHdG was significantly higher in group 2 compared to the other groups (p<0.001). IL-6 was different between groups. Group 2, IL-6 level was found to be significantly higher than the other groups (p<0.001). A positive correlation was found between serum 8-OHdG level and total cholesterol (r=0.417 p<0.001), LDL cholesterol (r=0.491 p<0.001) and triglyceride (r=0.441 p<0.001). A positive correlation was found between IL-6 and total cholesterol (r=0.522 p<0.001), LDL cholesterol (r=0.646 p<0.001) and triglyceride (r=0.495 p<0.001). IL-6 and 8-OHdG levels are high in dyslipidemic DM patients with a high lipid profile. IL-6 and 8-OHdG levels are elevated in dyslipidemic DM patients with a high lipid profile. IL-6 and 8-OHdG can be used as biomarkers to evaluate dyslipidemic complications seen in DM patients in the early diagnosis.

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Section: Introductionmentioning

confidence: 99%

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

Gulbay,

Kaya

2023

Med-Science

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“…Oxidative stress due to overproduction of reactive oxygen species (ROS) has important role in prevention, initiation, and progression of chronic diseases from early childhood [5]. The considerable reactive properties of ROS cause oxidative damage to lipids, deoxyribonucleic acid (DNA), and proteins.…”

Section: Introductionmentioning

confidence: 99%

The Activity of Serum 8-Iso-Prostaglandin F2<i>α</i> as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia

Mukhtar¹,

El-Emshaty²,

Al-Amodi³

et al. 2016

JDM

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Background: Oxidative stress has been closely linked to the incidence of diabetic complications. Therefore, the aim of this research article was to study hyperglycemia and abnormal lipid profile in diabetic patient type 2 and its correlation with oxidative stress development as measured by 8-iso-PGF2α and 8-OHdG. Methods: Fifty (50) patients confirmed type 2 diabetes mellitus and eighty (80) non-diabetic control individuals were included in this study. All individuals were tested for blood glucose, lipid profile, 8-iso-PGF2α and 8-OHdG HdG. Results: The age of diabetic patients was observed to be ≥40 yrs in 96% and diabetes was frequently detected in female than in male patients (76% vs. 24%, p < 0.0001). Mean serum lipids were elevated in diabetic patients compared with control individuals (p < 0.0001) except in HDL-C, a significant decrease was recorded (p = 0.04). Serum 8-iso-PGF2α and 8-OHdG were elevated significantly in diabetic patients compared with non-diabetic control and a significant correlation was recorded between them (r = 0.6, p < 0.0001). 8-iso-PGF2α was associated with Age (r = 0.

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Application of encapsulated natural bioactive compounds from red pepper waste in yogurt

Šeregelj

Šaponjac

Lević

et al. 2019

Journal of Microencapsulation

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Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents

Cited by 4 publications

References 29 publications

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

The Activity of Serum 8-Iso-Prostaglandin F2<i>α</i> as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia

Application of encapsulated natural bioactive compounds from red pepper waste in yogurt

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Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents

Cited by 4 publications

References 29 publications

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

Effects of lipids on inflammation and DNA damage in diabetes mellitus patients

The Activity of Serum 8-Iso-Prostaglandin F2&lt;i&gt;α&lt;/i&gt; as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia

Application of encapsulated natural bioactive compounds from red pepper waste in yogurt

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The Activity of Serum 8-Iso-Prostaglandin F2<i>α</i> as Oxidative Stress Marker in Patients with Diabetes Mellitus Type 2 and Associated Dyslipidemic Hyperglycemia