Evaluation of oxidative status in patients with &lt;i&gt;Fasciola hepatica&lt;/i&gt; infection

Karsen, Hasan; Sünnetçioğlu, Mahmut; Ceylan, RM; Bayraktar, Mehmet; Taşkın, Abdullah; Aksoy, Nurten; Erten, Remzi

doi:10.4314/ahs.v11i3.70064

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…Oxidative stress has an important role in the pathogenesis of viral hepatitis, sepsis and bacterial infections (13,14). Liver enzymes (ALT, AST, GGT), oxidative stress index-OSI and TOS increases are marked in animals with fascielosis, while TAS decreases in serum and plasma samples (15). In this study, the levels of TAS and TOS were increased in the peritoneal fluid compared with serum samples (Table 3) and some data supported our findings (14,16).…”

Section: Discussionsupporting

confidence: 79%

The Effects of L-Carnitine in Budd-Chiari Syndrome in a Domestic Cat

Öztürk¹,

Altuğ²,

Köse³

et al. 2016

Macedonian Veterinary Review

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Case Report Mac Vet Rev 2016; 39 (1): 123-127 This paper describes a thrombosis in the vena cava caudalis of a 15 year-old cat with ascites. Trauma and eventually feline enteric corona virus infection in the cat were not detected. In the intrahepatic region, a blockage of vena cava caudalis was brought to light by ultrasonographic imaging. An aspirate of abdominal fl uid revealed modified transudate. Liver enzyme levels were increased in the serum sample of the cat. The levels of total oxidant status (TOS) and total antioxidant status (TAS) were elevated in the peritoneal fluid. Liver protection diet with L-carnitine, diuretic therapy and antimicrobial drugs were administrated for treatment of the cat. During the continuous treatment, the amount of abdominal fluid decreased, but never completely absorbed. L-carnitine was administered to the cat during the time of treatment, and subsequently the levels of liver enzymes decreased. However, the cat died because of recurrent ascites and persistent thrombosis. In conclusion, ultrasonographic examination was very reliable, non-invasive and highly useful diagnostic method for BCS and L-carnitine has crucial effects on the quality of life, energy metabolism and liver enzyme levels. However, the blockage of the vena cava caudalis could not completely respond to medical treatment and thrombosis should be eliminated by surgical intervention.

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Section: Discussionsupporting

confidence: 79%

The Effects of L-Carnitine in Budd-Chiari Syndrome in a Domestic Cat

Öztürk¹,

Altuğ²,

Köse³

et al. 2016

Macedonian Veterinary Review

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“…Another study that investigated the oxidative status in Fasciola hepatica infections showed that plasma TOS levels and the oxidative stress index (OSI) were significantly increased in infected patients than in healthy controls. In contrast, they found that TAC levels were significantly lower in patients than in controls (19). CCHF may be possibly related to increased free radical production and antioxidant depletion, and oxidative stress may be implicated in CCHF pathogenesis.…”

Section: Introductionmentioning

confidence: 88%

Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever

et al. 2014

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In this study, we investigated the pro-and antioxidant status of patients with a pathogene-sis of Crimean-Congo hemorrhagic fever (CCHF) in terms of their role in its pathogenesis. During the study period, 34 children and 41 adults were diagnosed with CCHF. The control group consisted of healthy age-and gender-matched children and adults. Serum levels of the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and plasma total thiol (TTL) were evaluated and compared between groups. The difference in mean TAC values between CCHF patients and healthy controls was not statistically significant (P À 0.05). Mean TOS, OSI, and TTL values were significantly lower in CCHF patients than in healthy controls (P º 0.001). Comparisons between the 2 groups revealed that mean TOS and OSI values were significantly lower in adults with CCHF than in their healthy counterparts (P º 0.001). Similarly, mean TTL levels were lower in both children and adults with CCHF when compared separately with healthy controls (P º 0.05). There was no significant difference in the mean serum TTL levels between children and adults with CCHF (P À 0.05). Our results suggest that TTL may play a more important role in CCHF pathogenesis than the other parameters investigated. The mean TOS and OSI values were higher in the control group than in CCHF patients.

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“…Studies have reported that CAT is a major intracellular antioxidant enzyme (Aslan et al 2007;Simsek et al 2006) although, Karsen et al (2011) reported that CAT activity was found to be unimportant in fascioliasis since no statistically significant difference was available between patients and control groups (Ece et al 2006). LPO is an ongoing physiological process, but several lines of evidence have suggested an important role for peroxidation in the pathogenesis of several parasitic diseases (Erel et al 1997;Karsen et al 2011;Oliveira and Cechini 2002). LPO caused by ROS results in the disarrangement and ultimately, disruption of cell membranes, which leads to necrotic death (Bagchi et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis

2014

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The aim of this study was to examine the oxidative status in Egyptian patients suffering chronic fascioliasis. The relationship between serum malondialdehyde (MDA) levels, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities was investigated in relation to the level of liver enzymes; ALT and AST compared to healthy controls. Twenty patients versus ten controls were included in the study. Among cases the MDA, CAT, AST and ALT were higher than controls, while SOD and GPX higher values were present among controls. There was a highly significant difference between cases and controls as regard MDA, CAT, SOD, GPX, and AST, and a significant difference regarding ALT. The findings of increased serum lipid peroxidation and decreased antioxidant enzymes in erythrocytes of chronic fascioliasis patients indicated the presence of persistent inflammation and oxidative stress which confirms the underlying pathogenesis and reflected the stage of infection providing a baseline data for comparison between normal and infected patients guided by the level of liver enzymes in relation to oxidative status.

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Evaluation of oxidative status in patients with <i>Fasciola hepatica</i> infection

Cited by 12 publications

References 28 publications

The Effects of L-Carnitine in Budd-Chiari Syndrome in a Domestic Cat

The Effects of L-Carnitine in Budd-Chiari Syndrome in a Domestic Cat

Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever

Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis

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