Evaluation of oxidative stress and antioxidant status, serum trace mineral levels and cholinesterases activity in cattle infected with Anaplasma marginale

Esmaeilnejad, Bijan; Tavassoli, Mousa; Samiei, Awat; Hajipour, Nasser; Imani-Baran, Abbas; Farhang-Pajuh, Farhad

doi:10.1016/j.micpath.2018.07.039

Cited by 25 publications

(18 citation statements)

References 37 publications

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“…This agrees with El-Ashker et al [ 24 ] in A. marginale infection, Shiono et al [ 42 ] in T. sergenti infection in cattle, Mishra et al [ 43 ] and Parashar et al [ 44 ] in T. evansi infection in Holstein cattle and horses, respectively. The measurement of glutathione peroxidase and superoxide dismutase activities are indirect ways to evaluate the status of antioxidant defense of the body [ 45 ].The increase in the serum activities of glutathione peroxidase and superoxide dismutase (antioxidant enzymes) reported in this study is in contrast with Esmaeilnejad et al [ 46 ] who reported decreases in GPx and SOD activities in crossbred Holstein cattle naturally infected with A. marginale, and in [ 47 ] Rezaei and Dalir-Naghadeh [ 47 ] and Hassanpour et al [ 48 ] who reported decreased GPx and SOD activities in Holstein cattle with tropical theileriosis. The increase in serum SOD activity observed in A. platys infection from this study was different from that of Himalini et al [ 49 ] who reported a decrease in serum SOD activity in dogs with mixed Babesia canis and Anaplasma platys/phagocytophilum infection.…”

Section: Discussioncontrasting

confidence: 99%

High Granulocyte-Macrophage Colony Stimulating Factor to Interleukin 10 Ratio and Marked Antioxidant Enzyme Activities Predominate in Symptomatic Cattle Naturally Infected with Candidatus Mycoplasma haemobos, Theileria orientalis, Theileria sinensis and Trypanosoma evansi

Agina

Cheah

Sayuti

et al. 2021

Animals

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The aim of this study was to measure the serum proinflammatory (IL-12, GM-CSF & IFN-γ) to anti-inflammatory (IL-10, IL-4) cytokine ratio, oxidant (MDA) level and antioxidant enzyme (SOD; GPx) activities after blood parasite infections. The blood and serum samples were obtained from 130 cattle and screened for identity of the infecting blood parasites by conventional PCR. The following blood parasite species were detected: Candidatus Mycoplasma haemobos (70/130); Theileria orientalis (65/130); Theileria sinensis (32/130); Anaplasma marginale (49/130); Anaplasma platys (7/130); and Trypanosoma evansi (4/130). The GM-CSF/IL-10 ratio showed significantly higher values in all the symptomatic blood parasite infected cattle groups except for symptomatic A. platys infected cattle groups. Anti-inflammatory cytokine immune responses were notable findings in symptomatic and asymptomatic cattle infected with C. M. haemobos and T. orientalis characterized by low serum IL-12:IL-10, IFN-γ:IL-10, IL-12:IL-4 and IFN-γ:IL-4 (p < 0.05). Therefore, high serum GM-CSF:IL:10 in the symptomatic blood parasite infected cattle, low serum IL-12:IL-10, IFN-γ:IL-10, IL-12:IL-4 and IFN-γ:IL-4 ratios in asymptomatic cattle, high MDA level, and increased antioxidant enzyme activities could be useful predictive tools for outcome of natural blood parasite infections in cattle.

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Section: Discussioncontrasting

confidence: 99%

High Granulocyte-Macrophage Colony Stimulating Factor to Interleukin 10 Ratio and Marked Antioxidant Enzyme Activities Predominate in Symptomatic Cattle Naturally Infected with Candidatus Mycoplasma haemobos, Theileria orientalis, Theileria sinensis and Trypanosoma evansi

Agina

Cheah

Sayuti

et al. 2021

Animals

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“…Our results revealed significantly reduced GSH and TAC in the infected cattle, which is consistent with the suggestion that [ 5 ] the decrease in GSH in cattle with A. marginale infection might be due to either elevated activity of glutathione peroxidase that utilizes GSH to reduce peroxides or to its capacity to directly detoxify ROS. In this study, reduced serum TAC in the infected cattle may result from the exhaustion of antioxidant enzymes that act as scavengers for the free-radical throughout the oxidative process that occurs during A. marginale infection of cattle [ 11 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Changes in indices of oxidative stress are recorded in parasitic diseases. The role of erythrocytic peroxidation in the pathogenesis of several hemiparasitic infections is well recognized [ 7 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular diagnosis and biochemical studies of tick-borne diseases (anaplasmosis and babesiosis) in Aberdeen Angus Cattle in New Valley, Egypt

et al. 2020

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Background and Aim: Anaplasmosis and babesiosis are tick-borne diseases that threaten livestock production with subsequent considerable economic losses. This study was conducted to diagnose Anaplasma and Babesia infection using molecular techniques in imported Aberdeen Angus cattle imported from Uruguay to El-Kharga Oasis in New Valley, Egypt, and to investigate the effects of disease on some serum biochemical and oxidative stress parameters. Materials and Methods: Blood samples were collected from 31 cattle, 21 diseased and ten apparently normal, of varying ages and sex. The blood was used for the preparation of blood smears, polymerase chain reaction assay, and separation of serum for biochemical investigation. The experimental production farm at the Faculty of Agriculture, New Valley University, was infested with ticks and variable clinical manifestations during the period from December 2017 to March 2018. One calf died of a suspected blood parasite infection. Results: The blood film examination revealed infection by blood parasites in 21 samples. Anaplasma marginale and Babesia bovis were identified in 12 and 14 samples, respectively. A total of 14 samples were examined by polymerase chain reaction (PCR) to make these identifications. Biochemical parameters showed significantly elevated serum alanine aminotransferase, aspartate aminotransferase, total bilirubin (T. Bil), and urea in blood from parasite-infected female cattle and male calves compared with controls. Increased serum total protein, globulin, and creatinine were recorded only in infected female cattle. The blood glucose level was significantly decreased in infected female cattle and male calves compared with controls. Furthermore, albumin and albumin/globulin ratio was significantly reduced in the infected female cattle. Oxidative stress profiles of infected animals showed a significant increase in serum nitric oxide and malondialdehyde, and both total antioxidant capacity and reduced glutathione (GSH) were significantly reduced in comparison with control animals. Conclusion: The incidence of A. marginale and B. bovis infection is high in imported Aberdeen Angus cattle in New Valley Province. PCR methods provide a short-term assessment of disease. An extensive epidemiological survey, employing serology together with molecular genetic methods, monitoring of abundance and distribution of tick vectors, availability of vaccination programs, and tracking of animal transport is also needed for control of blood parasites.

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“…Glutathione peroxidase belongs to the glutathione antioxidant defense system and protects eukaryotic cells from oxidative damage (Espinosa-Diez et al, 2015). Glutathione peroxidase levels and activity are affected in different ways by Anaplasma marginale infection in both vertebrate and tick cells (Reddy et al, 1988; More et al, 1989; Kalil et al, 2017; Esmaeilnejad et al, 2018). While the activity and expression of glutathione peroxidase and other components of the antioxidant system was lower in A. marginale -infected cattle and water buffaloes (Reddy et al, 1988; More et al, 1989; Esmaeilnejad et al, 2018), glutathione peroxidase coding gene was upregulated in embryonic Rhipicephalus microplus BME26 cells in response to A. marginale infection (Kalil et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

et al. 2019

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Ticks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target genes interactions) plays a critical role in cell response to pathogen infection. Therefore, the application of regulomics to tick-pathogen interactions would advance our understanding of these molecular interactions and contribute to the identification of novel control targets for the prevention and control of tick infestations and tick-borne diseases. However, limited information is available on the role of tick regulome in response to pathogen infection. In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission.

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Evaluation of oxidative stress and antioxidant status, serum trace mineral levels and cholinesterases activity in cattle infected with Anaplasma marginale

Cited by 25 publications

References 37 publications

High Granulocyte-Macrophage Colony Stimulating Factor to Interleukin 10 Ratio and Marked Antioxidant Enzyme Activities Predominate in Symptomatic Cattle Naturally Infected with Candidatus Mycoplasma haemobos, Theileria orientalis, Theileria sinensis and Trypanosoma evansi

High Granulocyte-Macrophage Colony Stimulating Factor to Interleukin 10 Ratio and Marked Antioxidant Enzyme Activities Predominate in Symptomatic Cattle Naturally Infected with Candidatus Mycoplasma haemobos, Theileria orientalis, Theileria sinensis and Trypanosoma evansi

Molecular diagnosis and biochemical studies of tick-borne diseases (anaplasmosis and babesiosis) in Aberdeen Angus Cattle in New Valley, Egypt

Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets

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