Evaluation of Oxidative Stress and Antioxidant Status in Pregnant Anemic Women

Abstract

The present study was conducted to investigate the oxidant-antioxidant status in iron deficient pregnant anemic women. One hundred thirty pregnant women with iron deficiency anemia (IDA) were divided into three groups, namely mild (50), moderate (50) and severe (30) anemic along with pregnant healthy women as controls (50). The complete blood count, plasma lipid peroxidation products, enzymatic and non-enzymatic antioxidants were measured according to respective protocols. The levels of complete blood count, iron, ferritin along with antioxidant enzymes namely catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and reduced glutathione were significantly reduced in all IDA groups. However, the level of oxidized glutathione, lipid peroxides, protein carbonyls, conjugated dienes were found significantly increased in all anemic patients. Antioxidant vitamins, namely C, E and A were also found significantly decreased in IDA patients. On the basis of our results, it may be concluded that IDA tends to increase the pro-oxidant components, which may result in various complications including peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus.

Renal functional and structural integrity in infants with iron deficiency anemia: relation to oxidative stress and response to iron therapy

“…Similar to our results, increased parameters of oxidative stress, including MDA, in IDA have been reported in several studies [32][33][34][35]. Deokar et al [36] recently reported a significant increase in MDA in association with decreased antioxidants, SOD, vitamin C, vitamin E, and zinc in patients with IDA.…”

Association of Total Antioxidant Status with Severity of Anaemia in Pregnancy in Ogun state, Nigeria

“…About 50% of all anaemic cases in pregnant women have been attributed to iron deficiency, because iron requirements are not readily met by dietary intake alone especially if iron bioavailability is poor in the pregnant women [19]. In addition, decreased red blood cell survival which is secondary to an increased susceptibility to oxidant damage has been observed in anaemia [20]. In this study we observed a proportion of 46.5% (522/1122) pregnant women to be anaemic.…”

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

“…Moreover, we found that in the control and mild group less iron is utilized instead of moderate and severe anemic patients, which leads to make available more free iron in the body that in term may eventually further enhance the oxidative stress levels in this group. There have been reports that lipid peroxidation was significantly accelerated in iron deficiency anemia [27][28]. It is well known that lipid peroxidation is a free radicalmediated phenomenon and that the lipids in RBCs are susceptible to peroxidation in the pathophysiology of iron deficiency anemia.…”