Evaluation of Oxidative Stress in Laparoscopic Cholecystectomy

Zülfikaroğlu, Barış; Koç, Mahmut; Soran, Atilla; İşman, Ferruh Kemal; Cinel, İsmail

doi:10.1007/s005950200169

Cited by 62 publications

(63 citation statements)

References 26 publications

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“…In addition to these benefits, they also suggested that LC has less effects on oxidative stress than OC during surgery. Zulfikaroglu et al (2002) showed that the antioxidant defense system is stimulated less with less oxidative stress, providing further evidence to support the opinion that LC is a safe technique.…”

Section: Discussionmentioning

confidence: 53%

Effects of Open vs. Laparoscopic Cholecystectomy on Oxidative Stress

Bukan

Kaymakçıoğlu

et al. 2004

Tohoku J. Exp. Med.

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Elective laparoscopic cholecystectomy is established as the treatment of choice for symptomatic cholecystolithiasis and is now proposed for the treatment of acute cholecystitis. The aim of this study is to evaluate biochemical aspects of open (OC) and laparoscopic cholecystectomy (LC). We measured the levels of malondialdehyde (MDA) and the levels of nitrite+nitrate as stable end products of nitric oxide (NO). MDA and nitrite+nitrate levels were increased at both surgical procedures compared to preoperative period, but the rise was more significant in OC than LC. These results showed that both OC and LC caused an increase in oxidative stress. However LC caused significantly less oxidative stress and the changes during surgery returned to preoperative values after LC in a shorter period. The beneficial effects of laparoscopic surgery may be related, partially, to less oxidative stress in the immediate postoperative period. laparoscopic cholecystectomy; open cholecystectomy; oxidative stress

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Section: Discussionmentioning

confidence: 53%

Effects of Open vs. Laparoscopic Cholecystectomy on Oxidative Stress

Bukan

Kaymakçıoğlu

et al. 2004

Tohoku J. Exp. Med.

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“…34 In humans, studies comparing plasma markers of lipid peroxidation between laparoscopic and open cholecystectomy reported increased levels of markers in both groups with significantly increased levels in open surgery. 7,30,35 Pneumoperitoneum performed in rats with a pressure of 5, 10 or 15 mmHg resulted in an incremental increase in the formation of free oxygen radicals in lung and liver tissues. 36 In the study by Nickkholgh and colleagues, 10 histological and biochemical evidence of liver reperfusion injury was demonstrable at 12 mmHg but not at 8 mmHg.…”

Section: Discussionmentioning

confidence: 99%

Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

Yalçın¹,

Aydoğan²,

Serdaroğlu³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : This study aimed to investigate the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and the paraoxonase and arylesterase activities of patients with gallstones and compare them with healthy individuals as well as to assess the impact of sevoflurane and desflurane on oxidative stress markers in laparoscopic surgery. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty patients scheduled for laparoscopic surgery (Patient Group) and 30 healthy volunteers as control subjects (Control Group) were enrolled in the study. The patient group was randomized to desflurane group (n= 0) and sevoflurane group (n= 20). Blood samples were collected preoperatively and at postoperative 6 hours in order to measure the levels of TAS, TOS, OSI, and paraoxonase and arylesterase activities. Preoperative and postoperative laboratory findings of sevoflurane and desflurane group were compared with the Mann Whitney U test between groups and the Wilcoxon test within a group. R Re es su ul lt ts s: : Preoperative TOS, OSI levels in the patient group were significantly increased and arylesterase activities were significantly decreased compared to the control group (p<0.05) [(TOS (µmol H2O2 equiv/L), 19.64 ± 2.16 vs. 14.25 ± 1.83), (OSI 1.85 ± 0.53 vs. 0.98 ± 0.24), (Arylesterase (U/L), 45.19 ± 6.82 vs. 49.66 ± 4.78)]. There was no statistically significant difference between sevoflurane and desflurane group in laboratory findings of the preoperative and the postoperative period (p> 0.05). Preoperative and postoperative TAS, TOS, OSI results and activities of paraoxonase and arylesterase were not significantly different in the sevoflurane group (p> 0.05). Although the preoperative and postoperative levels of TAS and TOS and paraoxonase and arylesterase activities in the desflurane group was not significantly different, postoperative OSI was significantly increased (p< 0.05) (OSI 1.80 ± 0.57 vs 2.20 ± 0.67). C Co on nc cl lu us si io on n: : Patients with gallstone are exposed to a potent oxidative stress influencing TOS, OSI levels and arylesterase activities. Sevoflurane and desflurane had similar effects on oxidative stress during laporoscopic surgery in this patient group; however, OSI was increased in the desflurane group in the postoperative period compared to preoperative levels (p< 0.05).K Ke ey y W Wo or rd ds s: : Gallstones; laparoscopy; sevoflurane; desflurane; oxidative stress Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada, safra taşı olan hastalarda total oksidan seviye (TOS), total antioksidan seviye (TAS), oksidatif stres indeksi (OSİ) seviyelerinin ve paraoksonaz, arilesteraz aktivitelerinin, sağlıklı bireylerdeki parametrelerle karşılaştırılması ve laparoskopik cerrahide oluşan oksidatif stres üzerinde sevofluran ve desfluranın etkilerinin araştırılması amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Laparoskopik cerrahi planlanan 40 hasta (hasta grubu) ve 30 sağlıklı gönüllü (kontrol grubu) çalışmaya dâhil...

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“…[30][31][32] Two trials were only described in short. 33,34 As no language restriction was used, four publications were translated. [35][36][37][38] Double publications of trial results by the same research group were considered one trial.…”

Section: Resultsmentioning

confidence: 99%