Evaluation of Oxidative Stress in Liver Cirrhosis Patients to Early Diagnosis of Minimal Hepatic Encephalopathy

Sangeetha, K S Sridevi; Narayanasamy, Krishnasamy; Padma, K; Rajendran, Karthick

doi:10.9734/indj/2016/19004

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Inadequate levels of vitamin B 6 could limit glutathione synthesis, affecting the antioxidant capabilities of the liver. Cirrhosis is often associated with increased oxidative stress and decreased antioxidant capacities [38,39]; however, on evaluating the antioxidant effect of a combined supplementation of vitamin B 6 /glutathione in alcoholrelated cirrhotic patients, Lai et al showed that there were no significant effects on oxidative stress indicators [40].…”

Section: Vitamin B Groupmentioning

confidence: 99%

The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

et al. 2021

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Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. At present, treatment programs are focused on correcting vitamin deficiencies, which are frequently correlated to higher rates of comorbidities with poor outcomes. The literature reviewed here indicates that liver diseases are often related to vitamin disorders, due to both liver impairment and abnormal intake. More specific knowledge about the role of vitamins in liver disease is currently emerging from various results and recent evidence. The most significant benefits in this area may be observed when improved vitamin intake is combined with a pharmacological treatment that may also affect the progression of the liver disease, especially in the case of liver tumors. However, further studies are needed.

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Section: Vitamin B Groupmentioning

confidence: 99%

The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

et al. 2021

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“…The progression of liver cirrhosis is a multifactorial process that involves repetitive hepatocyte damage and subsequent irreversible scarring. In addition, increased oxidative stresses and decreased antioxidant capacities have been observed in cirrhotic patients [1][2][3][4][5]. Therefore, it is important for cirrhotic patients to restore the balance of oxidative stress and antioxidant capacities or even lean to a stronger antioxidant defense capacity to protect the liver from further damage, as well as decelerate the disease progression.…”

Section: Introductionmentioning

confidence: 99%

Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study

et al. 2020

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Vitamin B-6 and glutathione (GSH) are antioxidant nutrients, and inadequate vitamin B-6 may indirectly limit glutathione synthesis and further affect the antioxidant capacities. Since liver cirrhosis is often associated with increased oxidative stress and decreased antioxidant capacities, we conducted a double-blind randomized controlled trial to assess the antioxidative effect of vitamin B-6, GSH, or vitamin B-6/GSH combined supplementation in cirrhotic patients. We followed patients after the end of supplementation to evaluate the association of vitamin B-6 and GSH with disease severity. In total, 61 liver cirrhosis patients were randomly assigned to placebo, vitamin B-6 (50 mg pyridoxine/d), GSH (500 mg/d), or B-6 + GSH groups for 12 weeks. After the end of supplementation, the condition of patient’s disease severity was followed until the end of the study. Neither vitamin B-6 nor GSH supplementation had significant effects on indicators of oxidative stress and antioxidant capacities. The median follow-up time was 984 d, and 21 patients were lost to follow-up. High levels of GSH, a high GSH/oxidized GSH ratio, and high GSH-St activity at baseline (Week 0) had a significant effect on low Child–Turcotte–Pugh scores at Week 0, the end of supplementation (Week 12), and the end of follow-up in all patients after adjusting for potential confounders. Although the decreased GSH and its related enzyme activity were associated with the severity of liver cirrhosis, vitamin B-6 and GSH supplementation had no significant effect on reducing oxidative stress and increasing antioxidant capacities.

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Oxidative Stress Monitoring: Needs and Opportunities

Khelfi,

Mahmoud,

Perrone

et al. 2024

Biomarkers of Oxidative Stress

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Evaluation of Oxidative Stress in Liver Cirrhosis Patients to Early Diagnosis of Minimal Hepatic Encephalopathy

Cited by 4 publications

References 22 publications

The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?

Impact of Glutathione and Vitamin B-6 in Cirrhosis Patients: A Randomized Controlled Trial and Follow-Up Study

Oxidative Stress Monitoring: Needs and Opportunities

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