Evaluation of oxidative stress in the thrombolysis of pulmonary embolism

Mühl, Diána; Füredi, Réka; Cristofari, Julia; Ghosh, Subhamay; Bogár, Lajos; Borsiczki, Balázs; Gasz, Balázs; Röth, Elizabeth; Lantos, János

doi:10.1007/s11239-006-9035-2

Cited by 34 publications

(23 citation statements)

References 28 publications

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“…In previous studies related to PE, the changes of oxidative stress were examined by individual measurements such as SOD and MDA. It was shown that oxidative stress is notably important in PE (17,26). Our study is the first which investigates TOS, TAS and OSI levels in PE since oxidants and antioxidants have additive effects.…”

Section: Discussionmentioning

confidence: 84%

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Importance of Oxidative Stress in Pathogenesis and its Value in Diagnosis of Pulmonary Embolism Patients

Kavakli¹,

Çelik²,

Ahmedali³

et al. 2012

JAEM

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Section: Discussionmentioning

confidence: 84%

“…Acute pulmonary hypertension may cause right ventricular failure (acute cor pulmonale) and finally cardiogenic shock (14,16). In addition to all these events, the existence of oxidative stress in the pathophysiology of PE was shown by previous studies (6,(17)(18)(19).…”

Section: Discussionmentioning

confidence: 89%

Importance of Oxidative Stress in Pathogenesis and its Value in Diagnosis of Pulmonary Embolism Patients

Kavakli¹,

Çelik²,

Ahmedali³

et al. 2012

JAEM

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“…Tedavi öncesi ve sonrası MDA düzeyleri karşılaştı-rıldığında, tromboliz sonrasında MDA düzeyindeki yüksel-me istatistiksel olarak anlamlı bulunmuştur. Bu durum hipoksi reoksijenasyonu ve iskemi reperfüzyonunun, serbest oksijen radikalleri ve endojen antioksidanlar arasın-daki dengeyi bozarak oksidatif stresi arttırdığı şeklinde yorumlanmıştır [3]. Bizim çalışmamızda PE hastalarının sadece tanı sırasındaki serumları çalışılmış olup tedavi sonrası serum MDA seviyeleri değerlendirilmemiştir.…”

Section: Discussionunclassified

“…Pulmoner emboli nedeniyle ortaya çıkan pulmoner dolaşım yetmezliğinin sonucunda dolaşımda instabilite, hipoperfüzyon, hipoksi ve iskemi meydana gelir. Tüm bu durumlar organizmada oksidatif stres yaratır [3]. Oksidanantioksidan sistemler arasındaki dengenin bozulması olarak tanımlanan oksidatif stres, protein oksidasyonu ve lipid peroksidasyonu gibi mekanizmalarla doku hasarına neden olmaktadır [4,5].…”

Section: Introductionunclassified

The Diagnostic Value of Oxidative Stress Products in Pulmonary Embolism

Batmaz¹,

Edis²,

Eskiocak³

et al. 2011

Tur Toraks Der

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Amaç: Bu çalışmada, pulmoner embolili hastalarda oksidatif stres ürünleri olan iskemi modifiye albumin (IMA), ileri oksidasyon protein ürünü (AOPP) ve malondialdehit (MDA) düzeylerini belirleyerek pulmoner embolideki oksidatif stresin gösterilmesi amaçlanmıştır. Gereç ve Results:There was no significant difference between the two groups in terms of age, height, and weight. The difference in the AOPP levels of the two groups was not significant. The difference in the serum albumin levels of the two groups was found significant (p<0.001). The difference in levels of IMA after being corrected according to the albumin levels of the two groups was not significant. MDA levels of the two groups showed a significant difference (p=0.032). Conclusion:AOPP levels in patients with pulmonary embolism were not found different but, the increases of MDA levels were significant. We suggest using albumin-adjusted IMA levels to interpret IMA levels more correctly. We need more studies about using IMA levels as an indicator for diagnosis of pulmonary embolism. ( TANI YÖNTEMLERİ DIAGNOSTIC METHODS Pulmoner Embolide Oksidatif Stres Ürünlerinin Tanısal DeğeriThe GİRİŞPulmoner embolizm (PE), etkin tedavisi olmasına rağ-men mortalitesi yüksek seyreden bir hastalıktır [1].Oksidatif stres aralarında PE, akut myokard enfarktü-sü, geçici iskemik atak, inme ve akut mezenterik iskemi gibi tromboembolik hadiselerin de bulunduğu organizmadaki bir çok patolojik süreçte rol almaktadır [2]. Pulmoner emboli nedeniyle ortaya çıkan pulmoner dolaşım yetmezliğinin sonucunda dolaşımda instabilite, hipoperfüzyon, hipoksi ve iskemi meydana gelir. Tüm bu durumlar organizmada oksidatif stres yaratır [3]. Oksidanantioksidan sistemler arasındaki dengenin bozulması olarak tanımlanan oksidatif stres, protein oksidasyonu ve lipid peroksidasyonu gibi mekanizmalarla doku hasarına neden olmaktadır [4,5].Protein oksidasyonu, proteinlerin reaktif oksijen türev-leri veya oksidatif stres ürünleri ile kovalent modifikasyonu sonucu meydana gelir. Proteinlerde yapısal değişikliğe yol

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“…As a consequence of pulmonary circulatory failure resulting from pulmonary embolism, instability in circulation, hypoperfusion, hypoxia, and ischemia occur, all of which lead to oxidative stress in the organism [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism

İn

Deveci²,

Kaman³

2016

Blood Coagulation &Amp; Fibrinolysis

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We determined the levels of some heat shock proteins (HSP27, HSP70, and HSP90), L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) levels in patients with acute pulmonary embolism. The present case-control study comprised a healthy control group (n = 57) and patients with acute pulmonary embolism (n = 84). HSPs, L-arginine, ADMA, and SDMA levels were measured in all of the cases. The mean age of the control group was 56.72 ± 8.44 years, and the mean age of the patients with acute pulmonary embolism was 60.20 ± 16.56 years (P = 0.104). Compared with controls, patients with acute pulmonary embolism had significantly higher mean serum HSP27, HSP90, and ADMA levels, whereas the mean serum L-arginine and SDMA levels were lower (P < 0.001, for all parameters). In patients with acute pulmonary embolism serum HSP27, HSP70, and ADMA levels were negatively correlated with partial pressures of arterial oxygen levels (r = -0.281, P = 0.01; r = -0.263, P = 0.016; and r = -0.275, P = 0.011, respectively) and arterial oxygen saturation (r = -0.225, P = 0.039; r = -0.400, P < 0.001; r = -0.299, P = 0.006, respectively). The findings of the present study demonstrated that oxidative stress and endothelial damage increase in acute pulmonary embolism.

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Evaluation of oxidative stress in the thrombolysis of pulmonary embolism

Abstract: PE led to OS that was augmented following TL. Decreased adhesion molecule expression of circulating leukocytes in the early phase of TL reflects the pathological leukocyte endothelial cell interactions.

Cited by 34 publications

References 28 publications

Importance of Oxidative Stress in Pathogenesis and its Value in Diagnosis of Pulmonary Embolism Patients

Importance of Oxidative Stress in Pathogenesis and its Value in Diagnosis of Pulmonary Embolism Patients

The Diagnostic Value of Oxidative Stress Products in Pulmonary Embolism

Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism

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