Evaluation of oxidative stress in caprine anaplasmosis and effect of vitamin E–selenium in monitoring oxidative stress

Dhanasree, G; Pillai, Usha Narayana; Chirayath, Deepa; Ambily, V.R.; Shynu, M.; Sunanda, C.

doi:10.1007/s11250-019-02175-8

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…Vit. E has no role in increasing blood selenium, although it physiologically binds to each other to remove destructive peroxides at the cellular level [14]. Similar results have been reported by S h i et al [42] showing a significant increase in blood and tissue selenium following dietary selenium supplementation.…”

Section: Discussionsupporting

confidence: 70%

“…Therefore, selenium, especially with Vit. E [23], will protect cells from any oxidative stress damages [14].…”

Section: Discussionmentioning

confidence: 99%

“…Selenium and vitamin E (Vit. E) are considered as the most predominant antioxidants in animals, which minimize cell damage against membranes and intracellular peroxides, thus increasing the viability and functionality of cells [14]. Selenium has a biological action close to Vit.…”

Section: Introductionmentioning

confidence: 99%

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Correlations between Sodium Selenite and Vitamin E with Serum Macro-Minerals in Male Lambs

2022

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The effects of selenium and vitamin E (Vit. E) were evaluated on the macro-elements and their relationships were also surveyed. Lambs were divided into 4 groups of control, Vit. E, sodium selenite and sodium selenite/Vit. E (Se/E). Sodium selenite (0.1 mg.kg−1) and Vit. E (8 mg.kg−1) were administered. The mean blood selenium was high in sodium selenite. Selenium only in the Se groups was continuously increased. The lowest and highest blood selenium were in Vit. E and sodium selenite, respectively. The mean serum macro-minerals were within the normal range. The trend of calcium and magnesium in the selenium groups was to increase until day 60, but phosphorus was to decline. The lowest and highest calcium were observed in the control and sodium selenite groups, for magnesium in Vit. E and control groups, and for inorganic phosphorus were in the control group, respectively. The comparison of minerals showed that selenium had a significant increase from day 14 to 90 in sodium selenite. Selenium showed the most positive relationships with calcium and inorganic phosphorus in Vit. E and sodium selenite. Overall, selenium was correlated with macro-minerals on day 90 and overall sampling times were with calcium. In conclusion, administration of selenium with Vit. E increased selenium, which was more observed in the sodium selenite group. Sodium selenite alone or with Vit. E had no effect on the macro-minerals. The least correlation was observed between selenium and macro-minerals in the Se/E administration. The correlation between macro-minerals was positive. It was concluded that the effect of sodium selenite on treatment and prevention of selenium deficiency was more effective than other groups. Vit. E per selenium did not change the selenium concentration. Selenium administration was associated with an increase in calcium level and their co-administration is recommended.

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Section: Discussionsupporting

confidence: 70%

“…Therefore, selenium, especially with Vit. E [23], will protect cells from any oxidative stress damages [14].…”

Section: Discussionmentioning

confidence: 99%

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Correlations between Sodium Selenite and Vitamin E with Serum Macro-Minerals in Male Lambs

2022

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“…According to the latter study, CAT values peaked 28 days after vaccination or challenge with Brucella, which is indicative of the antioxidant effect against lipid peroxidation. In a study with goats infected with Anaplasma spp [43], a significant decrease in lipid peroxidation and an increase in CAT were found 10 days after the administration of Vit E/Se, but no difference was detected in the GSH values. According to our study, CAT activity was significantly increased 14 days post-vaccination in the VE group, which is in accordance with the aforementioned study and also may be related to the different vaccines used and the reduction of oxidative stress, which means that all peri-parturient ewes had a low antioxidant capacity [44].…”

Section: Discussionmentioning

confidence: 89%

Redox Status of Pregnant Ewes after Vaccination against Clostridial Diseases

et al. 2022

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The redox status shortly after the vaccination of pregnant ewes is rather unexploited. Thus, the present study was designed to evaluate the fluctuation of redox status after the administration of the annual booster dose of a polyvalent clostridial vaccine in pregnant ewes, 3 to 4 weeks before lambing, with or without a simultaneous injection of Vit E/Se. In total, 24 pregnant Lacaune ewes 3–4 weeks before lambing were randomly allocated into four equal groups: the V (vaccinated with a polyvalent clostridial vaccine), VE (vaccinated and injected IM with Vit E/Se), E (injected IM with Vit E and Se), and C (neither vaccinated nor injected with Vit E/Se). The study period lasted for 21 days, starting on the day of administration. Four redox biomarkers, the antioxidant capacity (TAC), the thiobarbituric acid reactive substances (TBARS), the reduced glutathione (GSH), and the catalase (CAT) were evaluated in blood samples collected from all ewes before the injections (0h) and then at 12 (12 h), 24 (D1), and 48 h (D2), and thereafter on days 4 (D4), 6 (D6), 10 (D10), 14 (D14), and 21 (D21). The results reveal that the TAC was the only biomarker evaluated that was significantly affected by group and significantly lower in vaccinated animals (V and VE groups) compared to non-vaccinated (E and C groups). The absence of an increase in the TBARS values after vaccination in groups V and VE indicates the absence of significant oxidative stress. Overall, it can be assumed that annual booster immunizations against clostridial diseases do not impose acute oxidative stress on pregnant ewes in the last month of pregnancy.

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“…Therefore, appropriate nutritional strategies, which are the key to compensating for the harm caused by heat stress-induced oxidative stress to sheep, must be adopted to meet the nutritional requirements of heat-stressed sheep. Currently, in animal production applications, a certain number of antioxidants, such as vitamin C, vitamin E (Dhanasree et al, 2020;Farahavar et al, 2020), arginine, sodium butyrate, and alpha-lipoic acid (LA), among others, are usually added to improve the ability to remove active oxygen in the body and reduce oxidative damage caused by high temperature, thereby improving the production performance and meat quality of animals in summer.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation with alpha-lipoic acid on apparent digestibility and serum metabolome alterations of sheep in summer

Zhang

Yang

et al. 2021

Trop Anim Health Prod

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To investigate the effects of alpha-lipoic acid (LA) on the nutrition metabolism of sheep (36.72 ± 1.44 kg) in the summer, twenty-one sheep were randomly assigned to three treatments addressing LA supplementation: 0.00 (CTL), 600 (LA-L), and 900 (LA-H) mg/kg of dry matter (DM) per day for each sheep. Whole feces and urine collection methods were used to analyze apparent digestibility; ELISA kits to determine the hormones, antioxidant, and immune parameters in the blood; and serum metabolomics to detect and analyze small molecular substances. The results showed the DM intakes in the LA-L and LA-H groups were significantly increased by 8.22% and 8.02%, respectively, compared to that in the CTL group, and there was no significant effect on average daily gain, feed conversion ratio, nitrogen digestibility, calcium digestibility, and phosphorus digestibility. Regarding hormones, antioxidant, and immune indicators, the concentrations of triiodothyronine, superoxide dismutase, glutathione reductase, HSP70, and IgA significantly increased after LA supplementation, while adrenaline and malondialdehyde levels significantly decreased. With the pairwise comparison of the three groups, metabolomics analysis identified 22 differential metabolites in the positive/negative modes, respectively, which suggested LA supplementation can significantly affect sheep's lipid, amino acid, and nucleic acid metabolism. Additionally, 3-indolepropionic acid, cinnamoylglycine, butyric acid, dodecanedioic acid, indoxyl sulfate, and pantothenic acid were the common differential metabolites with higher concentrations after LA supplementation. In summary, dietary supplementation of LA can increase the sheep's DMI, energy digestibility, antioxidant capacity, and immunity. These changes provide evidence to support the use of LA supplementation for livestock.

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Evaluation of oxidative stress in caprine anaplasmosis and effect of vitamin E–selenium in monitoring oxidative stress

Cited by 6 publications

References 15 publications

Correlations between Sodium Selenite and Vitamin E with Serum Macro-Minerals in Male Lambs

Correlations between Sodium Selenite and Vitamin E with Serum Macro-Minerals in Male Lambs

Redox Status of Pregnant Ewes after Vaccination against Clostridial Diseases

Effects of dietary supplementation with alpha-lipoic acid on apparent digestibility and serum metabolome alterations of sheep in summer

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