Evaluation of oxidative stress markers in subtypes of preeclampsia: A systematic review and meta-analysis

Freire, Victor Antonio Ferreira; Melo, Anderson Dutra de; Santos, Hérica de Lima; Pinheiro, Melina de Barros

doi:10.1016/j.placenta.2022.12.009

Cited by 14 publications

(6 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Glutathione metabolism is intricately linked to oxidative stress at the tissue level, and glutathione S-transferase is used as a biomarker to assess antioxidant activity . While most current investigations have focused on the role of glutathione in the development of preeclampsia, our research revealed a decrease in glutathione transferase activity (Gstm1, Gstm2, Gstt2) within the GDM placental tissue. These findings suggest a connection between dysregulated antioxidant activity and the pathogenesis of GDM, which may further influence fetal development and long-term health.…”

Section: Discussionmentioning

confidence: 74%

Sex-Specific Alterations in Placental Proteomics Induced by Intrauterine Hyperglycemia

Ren,

Luo,

Qin

et al. 2024

J. Proteome Res.

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) with intrauterine hyperglycemia induces a series of changes in the placenta, which have adverse effects on both the mother and the fetus. The aim of this study was to investigate the changes in the placenta in GDM and its gender differences. In this study, we established an intrauterine hyperglycemia model using ICR mice. We collected placental specimens from mice before birth for histological observation, along with tandem mass tag (TMT)-labeled proteomic analysis, which was stratified by sex. When the analysis was not segregated by sex, the GDM group showed 208 upregulated and 225 downregulated proteins in the placenta, primarily within the extracellular matrix and mitochondria. Altered biological processes included cholesterol metabolism and oxidative stress responses. After stratification by sex, the male subgroup showed a heightened tendency for immune-related pathway alterations, whereas the female subgroup manifested changes in branched-chain amino acid metabolism. Our study suggests that the observed sex differences in placental protein expression may explain the differential impact of GDM on offspring.

show abstract

Section: Discussionmentioning

confidence: 74%

Sex-Specific Alterations in Placental Proteomics Induced by Intrauterine Hyperglycemia

Ren,

Luo,

Qin

et al. 2024

J. Proteome Res.

View full text Add to dashboard Cite

show abstract

“…However, this appears not to be the case in pregnant women with HDP. While some studies have reported a decline in maternal antioxidant capacity in HDP, characterized by a decrease in the activity of enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) [46][47][48], others observed an upregulated antioxidant response [49,50], suggesting a compensatory mechanism to the heightened release of ROS. The indisputable fact is that there is an increase in ROS levels in HDP conditions.…”

Section: Endothelial Dysfunction Oxidative Stress and Hypertensive Di...mentioning

confidence: 99%

The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

Barbosa,

Tanus-Santos,

Cavalli

et al. 2024

Preprint

View full text Add to dashboard Cite

Hypertensive diseases of pregnancy (HDP) represent a global clinical challenge, affecting 5-10% of women and leading to complications for both maternal well-being and fetal development. At the heart of these complications is endothelial dysfunction, with oxidative stress emerging as a pivotal causative factor. The reduction in nitric oxide (NO) bioavailability is a vital indicator of this dysfunction, culminating in blood pressure dysregulation. In the therapeutic context, although antihypertensive medications are commonly used, they come with inherent concerns related to maternal-fetal safety, and a percentage of women do not respond to these therapies. Therefore, alternative strategies that directly address the pathophysiology of HDP are required. This article focuses on the potential of the nitrate-nitrite-NO pathway, abundantly present in dark leafy greens and beetroot, as an alternative approach to treating HDP. The objective of this review is to discuss the prospective antioxidant role of nitrate. We hope our discussion paves the way for using nitrate to improve endothelial dysfunction and control oxidative stress, offering a potential therapy for managing HDP.

show abstract

“…However, this appears not to be the case in pregnant women with HDPs. While some studies have reported a decline in maternal antioxidant capacity in HDPs, characterized by a decrease in the activity of enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) [50][51][52], others observed an upregulated antioxidant response [53,54], suggesting a compensatory mechanism to the heightened release of ROS. The indisputable fact is that there is an increase in ROS levels in HDP conditions.…”

Section: Endothelial Dysfunction Oxidative Stress and Hypertensive Di...mentioning

confidence: 99%

The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

Barbosa,

Tanus-Santos,

Cavalli

et al. 2024

Nutrients

View full text Add to dashboard Cite

Hypertensive diseases of pregnancy (HDPs) represent a global clinical challenge, affecting 5–10% of women and leading to complications for both maternal well-being and fetal development. At the heart of these complications is endothelial dysfunction, with oxidative stress emerging as a pivotal causative factor. The reduction in nitric oxide (NO) bioavailability is a vital indicator of this dysfunction, culminating in blood pressure dysregulation. In the therapeutic context, although antihypertensive medications are commonly used, they come with inherent concerns related to maternal–fetal safety, and a percentage of women do not respond to these therapies. Therefore, alternative strategies that directly address the pathophysiology of HDPs are required. This article focuses on the potential of the nitrate-nitrite-NO pathway, abundantly present in dark leafy greens and beetroot, as an alternative approach to treating HDPs. The objective of this review is to discuss the prospective antioxidant role of nitrate. We hope our discussion paves the way for using nitrate to improve endothelial dysfunction and control oxidative stress, offering a potential therapy for managing HDPs.

show abstract

Evaluation of oxidative stress markers in subtypes of preeclampsia: A systematic review and meta-analysis

Cited by 14 publications

References 106 publications

Sex-Specific Alterations in Placental Proteomics Induced by Intrauterine Hyperglycemia

Sex-Specific Alterations in Placental Proteomics Induced by Intrauterine Hyperglycemia

The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

Contact Info

Product

Resources

About