Evaluation of Oxidative Stress Parameters and Antioxidant Status in Plasma and Erythrocytes of Elderly Diabetic Patients with Sarcopenia

Küçükdiler, A. H. E.; Varlı, Murat; Yavuz, Özlem; Yalçın, Ahmet; Öztorun, Hande Selvi; Devrım, Erdinç; Aras, Sevgi

doi:10.1007/s12603-018-1137-y

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…In T2D patients, IR, ectopic lipid deposition, oxidative stress, endoplasmic reticulum stress, accumulation of advanced glycation end-products (AGEs), neuropathy and nephropathy can all cause damage. The synthesis and decomposition balance of skeletal muscle [ 34 , 35 ] and IR are the main pathogenic mechanisms of sarcopenia caused by diabetes. IR reduces protein synthesis by inhibiting the activation of the skeletal muscle differentiation signalling pathway and increases muscle protein decomposition by activating the ubiquitin–proteasome pathway [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Sedentary lifestyle and body composition in type 2 diabetes

Yang

Gao

et al. 2022

Diabetol Metab Syndr

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Background Body composition alterations may participate in the pathophysiological processes of type 2 diabetes (T2D). A sedentary lifestyle may be responsible for alterations of body composition and adverse consequences, but on which body composition of patients with T2D and to what extent the sedentary lifestyle has an effect have been poorly investigated. Methods We recruited 402 patients with T2D for this cross-sectional study. All patients received questionnaires to evaluate sedentary time and were further divided into three subgroups: low sedentary time (LST, < 4 h, n = 109), middle sedentary time (MST, 4–8 h, n = 129) and high sedentary time (HST, > 8 h, n = 164). Each patient underwent a dual energy X-ray absorptiometry (DXA) scan to detect body composition, which included body fat percentage (B-FAT), trunk fat percentage (T-FAT), appendicular skeletal muscle index (ASMI), lumbar spine bone mineral density (BMD) (LS-BMD), femoral neck BMD (FN-BMD), hip BMD (H-BMD) and total BMD (T-BMD). Other relevant clinical data were also collected. Results With increasing sedentary time (from the LST to HST group), B-FAT and T-FAT were notably increased, while ASMI, LS-BMD, FN-BMD, H-BMD and T-BMD were decreased (p for trend < 0.01). After adjustment for other relevant clinical factors and with the LST group as the reference, the adjusted mean changes [B (95% CI)] in B-FAT, T-FAT, ASMI, LS-BMD, FN-BMD, H-BMD and T-BMD in the HST group were 2.011(1.014 to 3.008)%, 1.951(0.705 to 3.197)%, − 0.377(− 0.531 to − 0.223) kg/m2, − 0.083(− 0.124 to − 0.042) g/cm2, − 0.051(− 0.079 to − 0.024) g/cm2, − 0.059(− 0.087 to − 0.031) g/cm2 and − 0.060(− 0.088 to − 0.033) g/cm2, p < 0.01, respectively. Conclusions A sedentary lifestyle may independently account for increases in trunk and body fat percentage and decreases in appendicular skeletal muscle mass and BMD of the lumbar spine, femoral neck, hip and total body in patients with T2D.

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Section: Discussionmentioning

confidence: 99%

Sedentary lifestyle and body composition in type 2 diabetes

Yang

Gao

et al. 2022

Diabetol Metab Syndr

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“…There are numerous studies that showed an inverse relationship between DTAC and sarcopenia. Kucukdiler et al have reported that oxidative stress is significantly higher in sarcopenic people (Küçükdiler et al, 2019 ). As well, in the Bernabeu‐Wittel study, 21.8% of sarcopenic subjects had higher oxidative stress markers (Bernabeu‐Wittel et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship of dietary total antioxidant capacity with sarcopenia and cardiometabolic biomarkers in type 2 diabetes patients

Baharirad

Pasdar

Nachvak

et al. 2022

Physiological Reports

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Background The aim of this study was to investigate the relationship of dietary total antioxidant capacity (DTAC) with sarcopenia and metabolic biomarkers in people with type 2 diabetes in the Kurdish race. Methods In this cross‐sectional study, data of 189 type 2 diabetic patients (35–65 years old) from RaNCD cohort study were evaluated. DTAC, fasting blood sugar, lipid profile, body composition, muscle strength, and sarcopenia were assessed. t and χ 2 tests to compare the variables between sarcopenic and non‐sarcopenic patients and one‐way analysis of variance to compare the variables in DTAC tertiles were used. The relationship between DTAC and different variables was evaluated using multiple logistic regression model. Results The mean age and body mass index were 49.7 ± 8.7 years and 27.1 ± 3.9 kg/m 2 . Body mass index, waist circumference, and hip circumference were significantly different between diabetic patients with and without sarcopenia ( p < 0.05). In crude ( p = 0.010) and adjusted ( p = 0.035) models, there was a significant relationship between DTAC and fasting blood sugar. Also, the relationship between DTAC with waist ( p = 0.019) and hip (β = −4.25, p = 0.026) circumference was significant. Sarcopenia was significantly lower in the third tertile in comparison with the first tertile of DTAC ( p = 0.016). Conclusion Diet with higher DTAC can be associated with lower fasting blood sugar, abdominal obesity and sarcopenia in type 2 diabetic patients. However, further studies are required to confirm these relationships.

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“…22 Another study in the literature showed that xanthine oxide levels, an oxidative parameter, were independently associated with sarcopenia in diabetes patients. 23 To summarize, sarcopenia is associated with oxidative stress, but studies in the literature have shown different results.…”

Section: Discussionmentioning

confidence: 99%

Thiol–disulfide homeostasis and ischemia‐modified albumin as a marker of oxidative stress in patients with sarcopenia

Özsürekçi

Ayçiçek

Çalışkan

et al. 2021

Geriatrics Gerontology Int

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Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. Chronic inflammatory conditions and increased oxidative stress are in the pathogenesis of sarcopenia. Our aim was to evaluate the relationship between sarcopenia and thiol-disulfide homeostasis and ischemia-modified albumin levels as an oxidative stress marker.Methods: Patients aged ≥65 years were recruited in this study. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criterion. Total thiol, native thiol, disulfide and ischemia-modified albumin levels were measures according to clinical and laboratory features. Patients were divided into two groups according to their sarcopenia presence; thiol-disulfide homeostasis and ischemia-modified albumin levels were evaluated between these groups.Results: Overall, 94 patients were analyzed. The mean age was 75.0 AE 6.71 years. A total of 39% of the patients were diagnosed as probable sarcopenia, 3.2% had sarcopenia, 6.4% had severe sarcopenia and 51.1% were diagnosed as normal. The levels of native thiol, total thiol, disulfide level and disulfide-native thiol, native thiol-total thiol and disulfide-total thiol ratios were similar in patients with sarcopenia when compared with the control group. In addition, there were no differences between albumin and ischemia-modified albumin levels. In univariate regression analysis, handgrip strength was found to be an independent predictor of native thiol and total thiol, and disulfide levels. Conclusion:This is the first study in the literature that evaluates the thiol-disulfide homeostasis and ischemia-modified albumin levels in sarcopenic older patients. Long-term studies are warranted to confirm the relationship between oxidative stress markers and sarcopenia.

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Evaluation of Oxidative Stress Parameters and Antioxidant Status in Plasma and Erythrocytes of Elderly Diabetic Patients with Sarcopenia

Cited by 14 publications

References 27 publications

Sedentary lifestyle and body composition in type 2 diabetes

Sedentary lifestyle and body composition in type 2 diabetes

The relationship of dietary total antioxidant capacity with sarcopenia and cardiometabolic biomarkers in type 2 diabetes patients

Thiol–disulfide homeostasis and ischemia‐modified albumin as a marker of oxidative stress in patients with sarcopenia

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