Evaluation of oxysterol levels of patients with silicosis by LC–MS/MS method

Aksu, Nalan Metin; Samadi, Afshin; Yalçınkaya, Ahmet; Çetin, Tuğçe; Eser, Burcu; Lay, İncilay; Öziş, Türkan Nadir; Öztaş, Yeşim; Sabuncuoğlu, Suna

doi:10.1007/s11010-020-03706-w

Cited by 16 publications

(11 citation statements)

References 47 publications

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“…7KC also appears to be involved in chronic inflammatory bowel diseases [ 33 ] as well as in some rare diseases of lipid metabolism, such as X-linked adrenoleukodystrophy (X-ALD) [ 11 , 34 ]. High levels of 7KC have also been described in non-infectious but severe inflammatory lung diseases such as silicosis [ 35 , 36 ]. In addition, air pollution which affects the respiratory system by promoting oxidative stress, increases the production of 7KC and promotes atherosclerosis by activating CD-36 positive macrophages [ 37 ].…”

Section: Pathologies Associated With 7-ketocholesterolmentioning

confidence: 99%

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

Ghzaiel

Sassi

Zarrouk

et al. 2021

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Pathologies Associated With 7-ketocholesterolmentioning

confidence: 99%

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

Ghzaiel

Sassi

Zarrouk

et al. 2021

The Journal of Steroid Biochemistry and Molecular Biology

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“…Furthermore, many metabolites are involved in the pathogenesis of silicosis and may play a predictive role in the diagnosis and severity of the disease. Research has also suggested that cholesterol oxidation can be used as an important marker and lipid metabolism is affected and oxidative lipid damage is triggered in silicosis [13].…”

Section: Introductionmentioning

confidence: 99%

Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case–control study

Xue

Fan

et al. 2021

BMC Pulm Med

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Background Silicosis is a progressive pneumoconiosis characterized by interstitial fibrosis following exposure to silica dust. The role of metabolic dysregulation in the pathogenesis of silicosis has not been investigated in detail. This study aimed to identify different metabolic features in the plasma of patients with silicosis and dust-exposed workers without silicosis in metabolomics studies. Methods Patients with silicosis, dust-exposed workers (DEWs) without silicosis and age-matched healthy controls were recruited in a case–control study. The metabolomics analyses by ultra-high performance liquid chromatography-mass spectrometry were conducted. Distinct metabolic features (DMFs) were identified in the pilot study and were validated in the validation study. The enriched signalling pathways of these DMFs were determined. The ability of DMFs to discriminate among the groups was analysed through receiver operating characteristic (ROC) curves. The correlations between DMFs and clinical features were also explored. Results Twenty-nine DMFs and 9 DMFs were detected and had the same trend in the pilot study and the validation study in the plasma of the DEW and silicosis groups, respectively. Sphingolipid metabolism was the major metabolic pathway in the DEWs, and arginine and proline metabolism was associated with silicosis. Twenty DMFs in the DEWs and 3 DMFs in the patients with silicosis showed a discriminatory ability with ROC curve analysis. The abundance of kynurenine was higher in Stage III silicosis than in Stage I or Stage II silicosis. l-arginine and kynurenine were both negatively correlated with the percentage of forced vital capacity predicted in silicosis. Conclusions Distinct metabolic features in the plasma of DEWs and the patients with silicosis were found to be different. Sphingolipid metabolism and arginine and proline metabolism were identified as the major metabolic pathway in the DEW and silicosis groups, respectively. l-arginine and kynurenine were correlated with the severity of silicosis.

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“…Because of their high reactivity and toxicity to the biological components of cells, these substances have attracted significant attention. Among them, 4-HNE is the most extensively researched, is frequently used as an oxidative stress marker [ 25 , 26 ], can be used with oxysterols to assess oxidative stress [ 27 , 28 ], and has been associated with the pathogenesis of cancer [ 29 , 30 ], neurodegenerative diseases [ 31 ], diabetes [ 32 ], and other diseases.…”

Section: Lipid Peroxidationmentioning

confidence: 99%

Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases

Zhao

et al. 2022

Journal of Immunology Research

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Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in the production of aldehydes, such as malondialdehyde and 4-hydroxy-2-nonenal (4-HNE) and other toxic substances. The compound 4-HNE forms adducts with DNA or proteins, disrupting many cell signaling pathways including the regulation of apoptosis signal transduction pathways. The binding of proteins to 4-HNE (4-HNE-protein) acts as an important marker of lipid peroxidation, and its increasing concentration in brain tissues and fluids because of aging, ultimately gives rise to some hallmark disorders, such as neurodegenerative diseases (Alzheimer’s and Parkinson’s diseases), ophthalmic diseases (dry eye, macular degeneration), hearing loss, and cancer. This review aims to describe the physiological origin of 4-HNE, elucidate its toxicity in aging-related diseases, and discuss the detoxifying effect of aldehyde dehydrogenase and glutathione in 4-HNE-driven aging-related diseases.

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Evaluation of oxysterol levels of patients with silicosis by LC–MS/MS method

Cited by 16 publications

References 47 publications

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

Distinct metabolic features in the plasma of patients with silicosis and dust-exposed workers in China: a case–control study

Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases

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