Evaluation of Ozone Therapy in Endodontic Treatment of Teeth with Necrotic Pulp and Apical Periodontitis: A Randomized Clinical Trial

Sinha, Nidhi; Asthana, Geeta; Parmar, Girish; Langaliya, Akshayraj; Shah, Jinali; Kumbhar, Aravind; Singh, Bijay

doi:10.1016/j.joen.2021.09.006

Cited by 9 publications

(15 citation statements)

References 31 publications

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“…Most studies showed homogeneity in their results, with I2 =96.8% >50% (Figure 1). Several articles demonstrated the effectiveness of ozone therapy in bone necrosis, in particular, osteomyelitis and drug necrosis [1][2][3]. Most of these necroses are sequelae of the treatment of malignant tumors.…”

Section: Resultsmentioning

confidence: 99%

“…Drug-induced bone necrosis establishes itself in the oral cavity as a form of exposed necrotic bone, for at least eight weeks, and is usually accompanied by pain, swelling of the oral mucosa, tooth mobility, erythema, and/or infections. It is related to therapies for the treatment of hypercalcemia, and osteoporosis and, mainly, to prevent bone metastasis from malignant tumors [2]. Such drug-based treatments, mainly anti-resorptive ones are bisphosphonates and denosumab.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, patients who receive radiotherapy, as a form of treatment against cancer, are greatly affected by osteoradionecrosis, and radiation can cause bone devitalization [2,3]. The bone becomes hypocellular, hypovascular, and hypoxic, which promotes ulceration, tissue necrosis, trismus, buccal fistula, and necrotic bone exposure, accompanied by pain and paresthesia [3].…”

Section: Introductionmentioning

confidence: 99%

“…inflammation of the bone marrow can cause compression of the bone tissue walls and decrease or blockage of blood supply in the region's blood vessels, which can induce bone necrosis[2,4].…”

mentioning

confidence: 99%

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Major approaches to ozone therapy in endodontic treatments for bone infections and necrosis: a systematic review

Azevedo¹,

Nunes²,

Sbrogio³

et al. 2022

MedNEXT

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Introduction: The bacterium Staphylococcus aureus is, in most cases, the agent of the disease. Thus, inflammation of the bone marrow can cause compression of the bone tissue walls and decrease or blockage of blood supply in the region's blood vessels, which can induce bone necrosis. Clinical studies have demonstrated the efficiency of ozone therapy in the treatment of peritonitis, infected wounds, and advanced ischemic disease. Objective: It was demonstrate the main scientific findings of the use of antiseptic ozone therapy in endodontic treatment. Methods: The research was carried out from July to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 127 articles were found, and 57 articles were evaluated and 29 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies with a high risk of bias and 28 studies that did not meet GRADE. Most studies showed homogeneity in their results, with I2 =96.8% >50%. Ozone therapy is scientifically proven and demonstrated in this work, it proved to be effective for tissue repair and the prevention and treatment of bone necrosis. It was observed that patients undergoing chemotherapy, radiotherapy, and antiresorptive drugs are more affected by bone necrosis. It was also observed the importance of the patient feeling that the treatment works and is restoring his ability to reinvent himself and adapt to his social environment. Treatments should not only be based on established numbers and protocols, without analyzing the specific sensations and perceptions of each patient with their lived reality.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…inflammation of the bone marrow can cause compression of the bone tissue walls and decrease or blockage of blood supply in the region's blood vessels, which can induce bone necrosis[2,4].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Major approaches to ozone therapy in endodontic treatments for bone infections and necrosis: a systematic review

Azevedo¹,

Nunes²,

Sbrogio³

et al. 2022

MedNEXT

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“…The use of ozone in Endodontics has been believed mainly for its powerful bactericidal action and low cytotoxicity 67 . Additionally, ozone therapy is non-traumatic, painless, and non-invasive, which increases patient acceptability 68 .…”

Section: Introductionmentioning

confidence: 99%

Irrigants and irrigation activation systems in Endodontics

Gomes,

Aveiro,

Kishen

2023

Braz. Dent. J.

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Root canal infections are typically polymicrobial and involve strong bacterial interactions. The goal of endodontic treatment is to remove infected content from the root canal system to allow the healing of a pre-existing periapical lesion or to prevent infection of the periradicular tissues. Instrumentation alone is not capable of touching all of the root canal walls. Therefore, the irrigation process is an essential step in the endodontic treatment. However, due to the complex anatomy of the root canal system, this cleaning is very challenging. Although syringe and needle irrigation associated with the use of chemical substances is still the most used method, it does not guarantee optimal cleaning of the root canals. As a result, not only alternative irrigating substances but also numerous activation systems - which are technologies that aim to optimize the action of irrigating substances, both chemically and physically - have been developed. This work aimed to review the characteristics of both classic and current alternatives of irrigating substances and irrigation activation systems.

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