Evaluation of p62c-myc in benign and malignant gastric epithelia

Immunohistochemical Analysis of the Expression of the c-<i>myc</i> Oncoprotein in Human Stomach Cancers

“…However, no association was found between the level of c-myc expression and the histological differ entiation by Allum et al [25] or ourselves in this investigation.…”

“…atrophic gastritis with intestinal metaplasia and atro phic gastritis with type 2b metaplasia) had higher levels of c-myc expression than the malignant tumors [25]. These authors sug gested that once malignant changes had oc curred, the c-myc level of expression fell off.…”

“…c-mvc overexpression has been previously reported in both benign and malignant gas tric lesions using the c-myc monoclonal anti bodies myc 1-6E10 [25,26] and with myc 1-9E10 [27]: however, no increase in c-myc expression was found in RNA hybridization studies in gastric carcinomas [19], Increased c-myc staining was reported in inflammato ry, metaplastic and displastic lesions of the stomach compared to normal tissue [26], In a study on both benign and malignant gastric lesions, it was found that the potentially ma lignant tissues of the stomach (i.e. atrophic gastritis with intestinal metaplasia and atro phic gastritis with type 2b metaplasia) had higher levels of c-myc expression than the malignant tumors [25].…”

“…14], In carcinoma of the colon, c-myc amplification is a rare finding [15][16][17], whereas c-myc overexpression is a relatively common fea ture of these tumors [15,[17][18][19], but few clinical correlations have been reported. In stomach cancer the c-myc gene has been found to be rarely amplified [20][21][22][23][24], al though this oncogene has been reported to be overexpressed in three out of four investiga tions into this disease [19,[25][26][27],…”