Evaluation of pain in patients with oral squamous cell carcinoma

Connelly, Stephen; Schmidt, Brian L.

doi:10.1016/j.jpain.2004.09.002

Cited by 112 publications

(158 citation statements)

References 31 publications

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“…26 Interestingly, patients with lymph node metastasis tended to report increased levels of spontaneous pain, suggesting that the process of tissue infiltration leading to metastasis may be responsible for increased spontaneous pain. 25 Increased preoperative CRP concentration was found to be associated with worse OS in patients with OSCC. 2 CRP is easy to measure, reproducible and familiar to clinicians.…”

Section: Discussionmentioning

confidence: 93%

“…23,24 Peripheral nociceptive mechanisms consistent with mechanical allodynia and hypersensitivity have been reported responsible for producing pain in patients with oral cancer. 25 For example, metabolic products of arachidonic acid, such as prostaglandins, are produced by OSCC cells, which sensitize primary afferent nociceptors and produce hyperalgesia. 25 This type of pain is histologically associated with tumor infiltration and compression of peripheral nerves and nociceptive receptors.…”

Section: Discussionmentioning

confidence: 99%

“…25 For example, metabolic products of arachidonic acid, such as prostaglandins, are produced by OSCC cells, which sensitize primary afferent nociceptors and produce hyperalgesia. 25 This type of pain is histologically associated with tumor infiltration and compression of peripheral nerves and nociceptive receptors. 24 Highly invasive tumors may directly stimulate peripheral nerve endings and nociceptive receptors.…”

Section: Discussionmentioning

confidence: 99%

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Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objectives:We have previously reported that the histological mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. We sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study Design:We evaluated the relationships between overall survival rates (OSRs) and clinicopathological variables, including gender, age, Tand N-stages, pathological findings and pain in 109 consecutive patients with untreated OSCC. Results:Of these 109 patients, 40 (37%) reported spontaneous pain.Univariate analysis showed that the OSR of patients with spontaneous pain was significantly lower than that of patients without pain (p=0.002).Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of OSR. Conclusion:This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.3

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…[37] Carcinoma-induced pain is not related to tumor size and small carcinomas produce severe pain. [6] These observations suggest that carcinoma pain is primarily of neuropathic origin and is characterized by mechanical hyperalgesia.…”

Section: Introductionmentioning

confidence: 99%

“…The mouse model can be used to test for analgesics. [6,42] We sought to determine whether peripheral cannabinoid agonists attenuate mechanical hyperalgesia in a carcinoma mouse model.…”

Section: Introductionmentioning

confidence: 99%

Peripheral cannabinoids attenuate carcinoma-induced nociception in mice

Guerrero

Quang

Dekker³

et al. 2008

Neuroscience Letters

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We investigated the cannabinoid receptor (CBr) agonists Win55,212-2 (non-selective) and AM1241 (CBr2 selective) and the peripheral receptor (CBr1) in carcinoma-induced pain using a mouse model. Tumors were induced in the hind paw of female mice by local injection of a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at four days after SCC inoculation and lasted to 18 days. Local administration of Win55,212-2 (10 mg/kg) and AM1241 (10 mg/kg) significantly elevated withdrawal thresholds, indicating an antinociceptive effect. Ipsilateral expression of CBr1 protein in L5 DRG was significantly upregulated compared to ipsilateral L4 DRG and in normal tissue. These findings support the suggestion that cannabinoids are capable of producing antinociception in carcinoma-induced pain.

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Protease‐Activated Receptor 2

Lee

2012

Therapeutic Targets

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Evaluation of pain in patients with oral squamous cell carcinoma

Cited by 112 publications

References 31 publications

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Peripheral cannabinoids attenuate carcinoma-induced nociception in mice

Protease‐Activated Receptor 2

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