Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease

Neves, Frederico Sampaio; Oliveira, Laudice Santos; Torres, Marianna Guanaes Gomes; Toralles, Maria Betânia Pereira; Silva, M. C. B. O. da; Campos, Maria Isabela Guimarães; Campos, P. S. F.; Crusoé‐Rebello, Iêda

doi:10.1007/s00198-011-1810-z

Cited by 16 publications

(13 citation statements)

References 30 publications

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“…Recent studies have assessed trabecular changes through bone structure visual estimation (Neves et al, ; Venela et al, ), which supports these paper's clinically applicable findings. This subjective evaluation should not be neglected as it could be applied by the dental professional on a regular daily basis.…”

Section: Discussionsupporting

confidence: 69%

“…This subjective evaluation should not be neglected as it could be applied by the dental professional on a regular daily basis. Under this perspective, a significant number of Sickle Cell Disease patients ( n = 71) presented increased trabecular bone marrow spacing when compared to the controls (Neves et al, ). Interesting, Venela et al () investigated intraoral images of patients with chronic renal failure, and their findings revealed the “granular chalky and white” trabecular shown by the dental imaging fields of view.…”

Section: Discussionmentioning

confidence: 99%

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Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

et al. 2018

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The purpose of this systematic review was to evaluate the potential use of dental imaging assessment of trabecular bone structure in the maxillomandibular complex as an adjuvant screening tool to identify systemic disorders. Five electronic databases and grey literature were searched. Studies were included if they investigated subjects with altered trabecular bone determined by dental radiographs. The QUADAS-2 assessed the risk of bias (RoB) among the studies, while the GRADE determined the strength of evidence. A total of 14 studies that included 1,466 individuals were considered eligible for the qualitative analysis. All studies presented an overall low RoB and low concern regarding applicability. Systemic disorders such as osteoporosis, osteogenesis imperfecta, diabetes, and primary hyperparathyroidism, with their respective control groups, were analyzed among the included studies.Osteoporosis was the condition presenting the most significant results, and 72% of the studies detected changes in the maxillomandibular trabecular bone structure.Studies exploring diabetic edentulous patients found less dense trabecular bone pattern (p < 0.05). In summary, periapical and panoramic radiographs, computed tomography, and cone beam computed tomography imaging could be considered useful for the assessment of the mandibular trabecular bone structure of patients affected by osteoporosis and patients with diabetes.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

et al. 2018

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“…Limited studies on SBD are available and its pathogenesis has been only partially investigated. 18,[43][44][45][46][47] Here we show bone impairment and bone loss in SCD mice under normoxic conditions. This was associated with downregulation of osteogenic markers (Runx2 and Sparc) and increased osteoclast activity (RankL) without major changes in osteoclastogenesis.…”

Section: Discussionmentioning

confidence: 59%

Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease

Carbonare

Mattè

Valenti

et al. 2015

Blood

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Key Points• In SCD, recurrent vasoocclusive crisis suppresses osteogenic lineage and activates osteoclasts.• Zoledronic acid acting on both osteoclast and osteoblast compartments is a multimodal therapy to prevent SBD.Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder, characterized by severe organ complication. Sickle bone disease (SBD) affects a large part of the SCD patient population, and its pathogenesis has been only partially investigated. Here, we studied bone homeostasis in a humanized mouse model for SCD. Under normoxia, SCD mice display bone loss and bone impairment, with increased osteoclast and reduced osteoblast activity. Hypoxia/reperfusion (H/R) stress, mimicking acute vaso-occlusive crises (VOCs), increased bone turnover, osteoclast activity (RankL), and osteoclast recruitment (Rank) with upregulation of IL-6 as proresorptive cytokine. This was associated with further suppression of osteogenic lineage (Runx2, Sparc). To interfere with the development of SBD, zoledronic acid (Zol), a potent inhibitor of osteoclast activity/ osteoclastogenesis and promoter of osteogenic lineage, was used in H/R-exposed mice. Zol markedly inhibited osteoclast activity and recruitment, promoting osteogenic lineage. The recurrent H/R stress further worsened bone structure, increased bone turnover, depressed osteoblastogenesis (Runx2, Sparc), and increased both osteoclast activity (RankL, Cathepsin k) and osteoclast recruitment (Rank) in SCD mice compared with either normoxic or single-H/R-episode SCD mice. Zol used before recurrent VOCs prevented bone impairment and promoted osteogenic lineage. Our findings support the view that SBD is related to osteoblast impairment, and increased osteoclast activity resulted from local hypoxia, oxidative stress, and the release of proresorptive cytokine such as IL-6. Zol might act on both the osteoclast and osteoblast compartments as multimodal therapy to prevent SBD. (Blood. 2015;126(20):2320-2328 IntroductionSickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder, which affects approximately 75 000 individuals in the United States and almost 20 000 to 25 000 individuals in Europe, this latter mainly related to the immigration fluxes from endemic areas such as Sub-Saharan Africa to European countries.1-3 Studies of the global burden of disease have pointed out the invalidating impact of SCD on patient quality of life.2 This requires the development of new therapeutic options to treat sickle cell-related acute and chronic complications.SCD is caused by a point mutation in the b-globin gene resulting in the synthesis of pathologic hemoglobin S (HbS). HbS displays peculiar biochemical characteristics, polymerizing when deoxygenated with associated reduction in cell ion and water content (cell dehydration), increased red cell density, and further acceleration of HbS polymerization. [4][5][6] Pathophysiologic studies have shown that dense, dehydrated red cells play a central role in acute and chronic clinical manifestations of ...

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“…30–31, 36–39 In the mandible, the cortical thickness measured from panoramic radiographs has been associated with the bone mineral density. 35, 40–45 In a previous study with cone beam computed tomography (CBCT) mandibular images, we reported that the cortical bone volume, area and height were significantly higher in cases of BRONJ than in controls. 46 These mandibular cortical bone measurements represent a potentially useful tool in the detection of bone alterations associated with bisphosphonate use and in patients specifically with BRONJ.…”

Section: Introductionmentioning

confidence: 99%

Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates

Torres

Chen

Lee

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective To detect dimensional changes in the mandibular cortical bone associated with bisphosphonate (BP) use and to correlate the measurements of the cortical bone with the cumulative dose of BP therapy. Methods Mandibular inferior cortical bone thickness (MICBT) was measured under the mental foramen from panoramic radiographs of subjects using BP with and without bisphosphonate related osteonecrosis of the jaws (BRONJ) and controls. Results The highest mean MICBT was observed in BRONJ subjects 6.81 (± 1.35 mm), when compared to subjects using BP 5.44 (± 1.09 mm) and controls 4.79 (± 0.85 mm; p<0.01). The mean MICBT of BRONJ subjects was significantly higher than that of subjects using BP without BRONJ. There was a correlation between MICBT and cumulative dose of zolendronate. Conclusion The MICBT on panoramic radiograph is a potentially useful tool for the detection of dimensional changes associated with BP therapy.

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Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease

Abstract: The radiomorphometric indices applied in the present study can be used on panoramic radiographs to detect the presence of low bone density in SCD subjects.

Cited by 16 publications

References 30 publications

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

Dental imaging of trabecular bone structure for systemic disorder screening: A systematic review

Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease

Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates

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