Evaluation of parasite resistance to commonly used commercial anthelmintics in meat goats on humid subtropical pasture

Abstract

Anthelmintic-resistant gastrointestinal nematode parasites are a threat to small ruminant industry sustainability. Meat goat does were administered one of four anthelmintics orally (ivermectin (n = 18), moxidectin (n = 18), levamisole hydrochloride (n = 17), or albendazole (n = 19)) or water (n = 18). Fecal samples were collected pretreatment and 12 days post-treatment. Fecal egg counts (FEC) were determined by the modified McMaster technique. The FEC reduction percentages (FECR%) were calculated using three equations. Log transformed FEC means were analyzed by treatment, sire breed of doe, and doe age. Sire breed affected (P < 0.05) pretreatment FEC, but not post-treatment FEC (P = 0.12). Pretreatment FEC did not differ (P = 0.21) by treatment group. Posttreatment FEC varied (P < 0.05) by treatment. Anthelmintic resistance determinations were based on FECR% falling below 90% or 80%, dependent on equation applied. Resistance was detected to all four anthelmintics using each equation. These results suggest the need for alternative methods of internal parasite control in goats.

Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States1

“…reported higher rates of clinical endoparasitism for Boer does than for Kiko and Spanish does. In agreement with the current study, 2 recent reports from this location (Goolsby et al, 2017;Wang et al, 2017) reported no differences between Kiko and Spanish does for FEC.…”

“…FAMACHA scores (a system of classifying eye color to detect endoparasite-induced anemia in small ruminants; Kaplan et al, 2004) are negatively correlated with PCV. Selecting and using genetically resistant goat breeds suitable to the particular environment could be an effective way to reduce endoparasitic loads, particularly since anthelmintic use is becoming a less reliable option for meat goat managers (Goolsby et al, 2017). Problems may arise if introduced goat breeds exhibit heightened sensitivity to endoparasites in a given production environment.…”

Resistência Parasitária De Nematódeos Gastrintestinais De Caprinos Criados Em Região Semiárida De Pernambuco, Nordeste Do Brasil

“…The 5% LMS hydrochloride resistance traits observed in some farms may be due to the low efficacy against immature stages of nematodes in general (4), i.e., the larvae residing in the gastrointestinal tract may have matured and started producing eggs (33). The results obtained in the present study corroborate the findings in the state of Ceará (4).…”

In Vitro Anthelmintic Evaluation of Gliricidia sepium, Leucaena leucocephala, and Pithecellobium dulce: Fingerprint Analysis of Extracts by UHPLC-Orbitrap Mass Spectrometry

“…Attempts at controlling gastrointestinal parasitism by using chemical substances indiscriminately without epidemiological knowledge [9] has given rise to anthelmintic resistance and chemical traces being present in both food and the environment [10]. This anthelmintic resistance has been demonstrated in different parts of the world [11][12][13][14][15][16]. In Colombia, multiple resistance in gastrointestinal nematodes (H. contortus, Trichostrongylus spp., and Cooperia spp.)…”