Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure

Ortatatli, Mustafa; Oguz, H.; Hatıpoğlu, Fatih; Karaman, Musa

doi:10.1016/j.rvsc.2004.06.006

Cited by 143 publications

(140 citation statements)

References 26 publications

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“…This might be due to hepatotoxic effect of aflatoxin, leading to significant changes of functioning and gross appearance of the liver (Tung et al 1973). Bursa of Fabricius is a major part of humoral and cellular immunity and any regression in bursal development would appear in poor immune response of broilers (Qureshi et al 1998;Ortatatli et al 2005). In line with this experiment, bursa of Fabrisius weight was significantly decreased in broilers fed by aflatoxin and T-2 toxin-contaminated diet (Girish & Devegowda 2006).…”

Section: Discussionsupporting

confidence: 67%

Effect of esterified glucomannan on broilers exposed to natural mycotoxin-contaminated diets

Mohaghegh

Chamani

Saifeddine

et al. 2016

Journal of Applied Animal Research

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The purpose of this study was to evaluate the effect of esterified glucomannan (E-GM) on performance, immunity, blood haematological and serum biochemical parameters in broilers exposed to diets naturally contaminated with mycotoxins. A total of 630 one-day-old male broiler chicks (Ross 308) were randomly assigned to 9 treatments and 5 replicates of 14 chicks based on factorial (3 × 3) arrangement in completely randomized design. The dietary treatments included 3 levels of substituting naturally contaminated corn (0%, 50% and 100%), three levels of E-GM (0%, 0.05% and 0.1%) and their interaction. Body weight gains (BWG), feed intake (FI) and feed conversion ratio (FCR) were evaluated from 7 to 49 days of age. Haematology, serum biochemical and enzyme activities were assessed. Antibody titre against Newcastle disease virus and infectious bursal disease was measured to evaluate the humoral immunity. In comparison to diets with no contamination, 50% and 100% naturally contaminated corn significantly decreased FI, BWG and FCR (P < .05). Supplementing 0.05% and 0.1% E-GM considerably improved the decreased BWG and FI (P < .05). However, only 0.1% binder ameliorated the negative impact of mycotoxins on FCR (P < .05). Replacement of contaminated corn remarkably diminished humoral immunity of chickens and increased liver enzyme activities which ameliorated by supplementing 0.05% and 0.1% of binder inclusion (P < .05). Results indicated that supplementing E-GM particularly at 0.1% level efficiently reversed the adverse effects of mycotoxins on broiler chickens. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 67%

Effect of esterified glucomannan on broilers exposed to natural mycotoxin-contaminated diets

Mohaghegh

Chamani

Saifeddine

et al. 2016

Journal of Applied Animal Research

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“…In poultry, the histopathological hepatic changes caused by lower levels of aflatoxin are more expressed than those of other organs (25). Hepatomegaly, hydropic and fatty changes, and acinar arrangements in hepatocytes, periportal fibrosis, and bile duct proliferation were noted.…”

Section: Discussionmentioning

confidence: 99%

“…The liver is considered to be the primary target organ for aflatoxin (25). Thus the aim of our study was to assess the impact of 250 ppb aflatoxin, a level which has been shown to occur under field conditions, on pathological changes in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…The biochemical, haematological (4,22), immunological (17), and pathological (24) effects of aflatoxin have also been described in details. Aflatoxin can also cause significant gross and microscopic alterations in the liver, such as hepatomegaly, paleness, hydropic and fatty degeneration, bile duct hyperplasia, and periportal fibrosis (10,25).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of serum biochemical parameters and pathological changes in broilers with chronic aflatoxicosis fed glucomannan-containing yeast product (Mycosorb) and sodium bentonite

Azizpour

Moghadam

2015

Bulletin of the Veterinary Institute in Pulawy

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The purpose of this study was to evaluate the efficacy of yeast glucomannan (YG) and sodium bentonite (SB) in reducing the toxicity in broilers fed a diet naturally contaminated with aflatoxin. Three hundred 7-day-old Ross 308 strain broilers were chosen and randomly assigned to 10 dietary treatments. Serum biochemical parameters and pathological changes in the liver were investigated at 42 d of age. Chickens fed a diet containing 250 ppb of aflatoxin displayed a decrease in uric acid, cholesterol, and triglycerides, and an increase in serum activities of AST and ALT when compared to control group. There were considerable gross and histopathological hepatic lesions (P < 0.05) in the form of small to moderate hydropic and/or fatty degeneration, bile duct hyperplasia, periportal fibrosis, cells infiltration, and congestion, in chickens fed the 250 ppb aflatoxincontaining diet. The addition of YG and SB to the aflatoxin-containing diet partially reduced the negative effects of aflatoxin. The 0.1% YG supplementation to the aflatoxin-contaminated diet significantly prevented the pathological effect of aflatoxin on serum biochemical parameters and liver, and was found to be more effective than other treatments.

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“…Attention given fungi has focused mainly on toxin-producing fungi and yeast. Toxin-producing fungi as feed contaminants can result in harmful effects and decreased performance ( Javed et al, 2005;Kumar et al, 2003;Ortatatli et al, 2005). Conversely, yeast and yeast products are promoted for their potential to enhance poultry production and protect against human enteropathogen colonization (Baurhoo et al, 2007;Owens et al, 2008).…”

mentioning

confidence: 99%

Molecular Identification and Characterization of Ileal and Cecal Fungus Communities in Broilers Given Probiotics, Specific Essential Oil Blends, and Under MixedEimeriaInfection

Hume

Hernandez

Barbosa

et al. 2012

Foodborne Pathogens and Disease

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Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure

Cited by 143 publications

References 26 publications

Effect of esterified glucomannan on broilers exposed to natural mycotoxin-contaminated diets

Effect of esterified glucomannan on broilers exposed to natural mycotoxin-contaminated diets

Assessment of serum biochemical parameters and pathological changes in broilers with chronic aflatoxicosis fed glucomannan-containing yeast product (Mycosorb) and sodium bentonite

Molecular Identification and Characterization of Ileal and Cecal Fungus Communities in Broilers Given Probiotics, Specific Essential Oil Blends, and Under MixedEimeriaInfection

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