Evaluation of patients with Alzheimer's disease before and after dental treatment

Rolim, Thaís de Souza; Fabri, Gisele Maria Campos; Nitrini, Ricardo; Anghinah, Renato; Teixeira, Manoel Jacobsen; Siqueira, José Tadeu Tesseroli de; Cesari, José Augusto Ferrari; Siqueira, Sílvia Regina Dowgan Tesseroli de

doi:10.1590/0004-282x20140140

Cited by 44 publications

(41 citation statements)

References 24 publications

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“…The 99 remaining full text articles were then examined for eligibility, of which 62 were then excluded because they did not meet the inclusion criteria. Only one study was added through scanning the reference lists of the included articles [19]. Thereafter, the quality of the 37 included studies was assessed.…”

Section: Resultsmentioning

confidence: 99%

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Oral health and orofacial pain in older people with dementia: a systematic review with focus on dental hard tissues

et al. 2016

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ObjectiveThe aim of this review was to provide a systematic overview including a quality assessment of studies about oral health and orofacial pain in older people with dementia, compared to older people without dementia.MethodsA systematic literature search was performed in PubMed, CINAHL, and the Cochrane Library. The following search terms were used: dementia and oral health or stomatognathic disease. The quality assessment of the included articles was performed using the Newcastle-Ottawa Scale (NOS).ResultsThe search yielded 527 articles, of which 37 were included for the quality assessment and quantitative overview. The median NOS score of the included studies was 5, and the mean was 4.9 (SD 2.2). The heterogeneity between the studies was considered too large to perform a meta-analysis. An equivalent prevalence of orofacial pain, number of teeth present, decayed missing filled teeth index, edentulousness percentage, and denture use was found for both groups. However, the presence of caries and retained roots was higher in older people with dementia than in those without.ConclusionsOlder people with dementia have worse oral health, with more retained roots and coronal and root caries, when compared to older people without dementia. Little research focused on orofacial pain in older people with dementia.Clinical relevanceThe current state of oral health in older people with dementia could be improved with oral care education of caretakers and regular professional dental care.

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Section: Resultsmentioning

confidence: 99%

“…Although dental hard tissues can be an important source of orofacial pain, only seven of the included studies published data about the presence of orofacial pain [15, 19, 28, 33, 34, 44, 74]. The presence of reported dental pain in older people with dementia varied between 7.4 and 21.7 %.…”

Section: Resultsmentioning

confidence: 99%

Oral health and orofacial pain in older people with dementia: a systematic review with focus on dental hard tissues

et al. 2016

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“…Nevertheless, the role of periodontal health for cognitive impairment disease should still be emphasized for the need of functional improvement in the current quality of life of these patients. A study also revealed that periodontal treatment had the effect of reducing co‐morbidities associated with Alzheimer's disease, and routine assessment should be included for these patients (Rolim et al, ). The individuals with cognitive impairment require special attention towards overall oral health care, oral hygiene education, and periodontal maintenance, which may improve daily life activities and life quality (Martande et al, ; Rozas, Sadowsky, & Jeter, ).…”

Section: Discussionmentioning

confidence: 99%

Association between periodontitis and cognitive impairment: Analysis of national health and nutrition examination survey (NHANES) III

Sung

Huang

Cheng

et al. 2019

J Clinic Periodontology

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Objectives Periodontitis has been hypothesized as being one of the most common potential risk factors for the development of dementia and cognitive impairment. In order to investigate the relationship between periodontitis and cognition impairment, the National Health and Nutrition Examination Survey (NHANES) database was analysed after adjusting for potential confounding factors, including age and other systemic co‐morbidities. Materials and Methods In total, 4,663 participants aged 20–59 years who had received full‐mouth periodontal examination and undergone the cognitive functional test were enrolled. The grade of periodontal disease was categorized into severe, moderate, and mild. Cognitive function examinations, including the simple reaction time test (SRTT), symbol digit substitution test (SDST), and serial digit learning test (SDLT), were adopted for the evaluation of cognitive impairment. Results The subjects with mild and moderate to severe periodontitis had higher SDLT and SDST scores, which indicated decreased cognitive function, compared with the healthy group. After adjusting for demographic factors, education, smoking, cardiovascular diseases, and laboratory data, periodontitis was significantly correlated with elevated SDST and SDLT scores (p values for trend = 0.014 and 0.038, respectively) by generalized linear regression models. Conclusion Our study highlighted that periodontal status was associated with cognitive impairment in a nationally representative sample of US adults.

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“…A risk factor relationship between periodontal pathogens/periodontal disease and AD exists, as previously discussed by Olsen and Singhrao [3]. Salient points are that periodontal disease is co-morbid with clinically demented subjects [4][5][6][7]. Tooth loss in early and midlife has consequences for poor memory in later life [4,[7][8][9][10][11][12].…”

Section: Making a Case For Periodontitis As A Risk Factor For Alzheimmentioning

confidence: 99%

“…A prospective longitudinal study reported by Ide et al [7] upholds the view that periodontitis is associated with a marked increase in cognitive decline, which is independent of base line cognition, in men with a mild to moderate clinical diagnosis of dementia. A study following the impact of a dental intervention on patients with a clinical diagnosis of mild AD found over 50% of participants (who also suffered from gingivitis/periodontitis) showed improvements in their memory [6]. Oral bacteria and their virulence factors affect the central nervous system pathology [13,14], and indiscriminate release of inflammatory mediators cause neuronal injury [5,[15][16][17].…”

Section: Making a Case For Periodontitis As A Risk Factor For Alzheimmentioning

confidence: 99%

Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?

Harding

Robinson

Crean

et al. 2017

JAD

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A risk factor relationship exists between periodontal disease and Alzheimer's disease (AD) via tooth loss, and improved memory following dental intervention. This links the microbial contribution from indigenous oral periodontal pathogens to the manifestation of chronic conditions, such as AD. Here, we use Porphyromonas gingivalis infection to illustrate its effect on mental health. P. gingivalis infection, in its primary sub-gingival niche, can cause polymicrobial synergy and dysbiosis. Dysbiosis describes the residency of select commensals from the oral cavity following co-aggregation around the dominant keystone pathogen, such as P. gingivalis, to gain greater virulence. The initial process involves P. gingivalis disturbing neutrophil mediated innate immune responses in the healthy gingivae and then downregulating adaptive immune cell differentiation and development to invade, and subsequently, establish new dysbiotic bacterial communities. Immune responses affect the host in general and functionally via dietary adjustments caused by tooth loss. Studies from animals orally infected with P. gingivalis confirm this bacterium can transmigrate to distant organ sites (the brain) and contribute toward peripheral and intracerebral inflammation, and compromise vascular and microvascular integrity. In another study, P. gingivalis infection caused sleep pattern disturbances by altering glial cell light/dark molecular clock activity, and this, in turn, can affect the clearance of danger associated molecular patterns, such as amyloid-␤, via the glymphatic system. Since P. gingivalis can transmigrate to the brain and modulate organ-specific inflammatory innate and adaptive immune responses, this paper explores whether better management of indigenous periodontal bacteria could delay/prevent the onset and/or progression of dementia.

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Evaluation of patients with Alzheimer's disease before and after dental treatment

Cited by 44 publications

References 24 publications

Oral health and orofacial pain in older people with dementia: a systematic review with focus on dental hard tissues

Oral health and orofacial pain in older people with dementia: a systematic review with focus on dental hard tissues

Association between periodontitis and cognitive impairment: Analysis of national health and nutrition examination survey (NHANES) III

Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?

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