Evaluation of patients with symptomatic dermographism

Taşkapan, Oktay; Harmanyeri, Yavuz

doi:10.1111/j.1468-3083.2005.01372.x

Cited by 49 publications

(53 citation statements)

References 7 publications

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“…It is usually idiopathic, but it may be associated with systemic use of penicillin, famotidin, and atorvastatin [27,28]. In a review of 40 patients, there is a close relationship between dermatographism and psychic factors, drug reactions, and scabies [27]. Superficial, perivascular leukocytic infiltrations are found in skin.…”

Section: Discussionmentioning

confidence: 99%

“…Superficial, perivascular leukocytic infiltrations are found in skin. Biopsy of the lesions reveals few infiltrating eosinophils and neutrophils associated with minimal extracellular major basic protein and neutrophil elastase deposition [27].…”

Section: Discussionmentioning

confidence: 99%

“…Dermatographism could be seen in 1.5-5% of the healthy population [26,27]. Pathogenesis of dermatographism is unclear [19].…”

Section: Discussionmentioning

confidence: 99%

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Adult-onset Still’s disease: a report of 28 cases and review of the literature

et al. 2008

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Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. It is characterized by fever, skin rash, polyarthralgias or polyarthritis, sore throat, hepatosplenomegaly, lymphadenopathy, leukocytosis, liver enzyme elevation, and high serum level of ferritin. Several kinds of skin lesions have been reported in this condition. The aim of this study was to assess the clinical and laboratory aspects of 28 patients with AOSD in central Iran. According to the diagnostic criteria of AOSD, we identified 28 patients between 2002 and 2007. We intended to describe the clinical characteristics, treatment, and outcome of our patients with AOSD. Of 28 patients with AOSD, 21 (75%) were female, 7 (25%) were male. Fever (100%), sore throat (92%), Arthralgia (92%), dermatographism (92%), typical rash (85%) and arthritis (60%) were the most common findings. The mean values of laboratory findings were as follows; C-reactive protein (CRP) level of 14.4 mg/dl, erythrocyte sedimentation rate (ESR) of 91.5 mm/h, leukocyte count of 15744.4/microl. Abnormal levels of aspartate aminotransferase and alanine aminotransferase were observed in 25 (89%) patients. Twenty patients (71%) had high ferritin values (>500 ng/ml). The clinical characteristics were similar to previous series. A febrile polyarthritis was the most frequent presentation form. Dermatographism was frequently encountered phenomenon in our patients with AOSD. Being that dermatographism is a simple inducible skin reaction, along with its sensitivity in active disease, we suggest more controlled studies to validate accuracy and positive predictive value of it in convenient clinical setting in the diagnosis of AOSD and to consider including it in diagnostic criteria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adult-onset Still’s disease: a report of 28 cases and review of the literature

et al. 2008

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“…Typically, uriticaria pigmentosa lesions can show Darier's sign, or development of a wheal and flare after these lesions are lightly stroked. While patients with mastocytosis can also show dermatographism, this latter condition is much more common, affecting up to 5% of the general population [41], and does not necessarily indicate the presence of a mast cell disease in most patients. Patients with mastocytosis do not have higher incidence of chronic or acute urticaria, although children with mastocytoma have been known to develop generalized hives after physical irritation of the lesion [42].…”

Section: Flushing and Rashesmentioning

confidence: 99%

Mastocytosis and allergy

Greenhawt

Akin

2007

Current Opinion in Allergy &Amp; Clinical Immunology

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“…SD is a debilitating condition and the most common form of CINDU that impairs QoL significantly [15, 16]. …”

Section: Discussionmentioning

confidence: 99%

Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index

Can¹,

Etikan²,

Kızıltaç³

et al. 2018

Int Arch Allergy Immunol

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Background: Fric test is a useful tool for the diagnosis and threshold testing for symptomatic dermographism. When threshold testing is not available, Urticaria Control Test (UCT) and Dermatology Life Quality Index (DLQI) might be used to assess disease control and quality of life (QoL) impairment, respectively. Objectives: In this study, we aimed to describe a new scoring system for the Fric test and evaluate the correlations of Fric scores with UCT, DLQI, and other disease activity assessment scores. Method: Provocation test with Fric Test 4.0 was performed in all patients at referral and at the 4th week. We considered a 4-grade rating score for Fric Test (0–4) [Total Fric Score (TFS)]. A positive response with all of the four pins suggested severe dermographism (TFS = 4), while a wheal with only the largest pin (4.5 mm) was considered as milder disease (TFS = 1). Treatment responses were evaluated with Fric Test 4.0, UCT, patient’s global assessment of disease severity (PatGA-VAS), the physician’s global assessment of disease control (PhyGA-VAS), and DLQI at baseline and at the 4th week of treatment. The correlations of TFS with UCT, DLQI, PatGA-VAS, PhyGA-VAS at baseline as well as the changes in the mean scores after treatment (week 4) were performed. Results: The mean UCT and DLQI scores were 8.69 ± 3.40 and 7.88 ± 6.02 at the first visit. At the second visit, TFS decreased from a mean of 2.79 ± 1.68 to 1.91 ± 1.85 (p < 0.001), and UCT scores and PhyGA-VAS were increased (p < 0.001), while DLQI scores, PatGA-VAS, and pruritus scores decreased significantly (p = 0.002; p = 0.001; p = 0.012). There was a positive correlation between TFS and pruritus scores (r = 0.378) and DLQI scores (r = 0.392). TFS was found to have a negative correlation with UCT score (r = –0.283) and PhyGA-VAS (r = –0.347). Conclusions: This new Fric scoring system allows comparison with other tools and shows moderate correlations with most of the tools. Using disease-specific tools is recommended since they provide a subjective evaluation of disease severity, QoL impairment, and disease control.

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Evaluation of patients with symptomatic dermographism

Cited by 49 publications

References 7 publications

Adult-onset Still’s disease: a report of 28 cases and review of the literature

Adult-onset Still’s disease: a report of 28 cases and review of the literature

Mastocytosis and allergy

Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index

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