Evaluation of Pentravan ® , Pentravan ® Plus, Phytobase ® , Lipovan ® and Pluronic Lecithin Organogel for the transdermal administration of antiemetic drugs to treat chemotherapy-induced nausea and vomiting at the hospital

Bourdon, Françoise; Lecoeur, Marie; Leconte, L.; Ultre, Vincent; Kouach, Mostafa; Odou, Pascal; Vaccher, Claude; Foulon, Catherine

doi:10.1016/j.ijpharm.2016.11.014

Cited by 17 publications

(5 citation statements)

References 40 publications

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“…Among these bases, Pentravan ® is an oil-in-water emulsion with a liposomal matrix and a variety of permeation enhancers. It has shown improved skin penetration for many active ingredients [ 29 , 30 , 31 ]. Unlike Pluronic Lecithin Organogel (PLO) and other lipophilic bases, Pentravan’s true disappearance and fast permeability means it leaves no sticky residue on the skin and, most importantly, does not require an occlusive dressing after application, making it easier for people to comply and for communities to use it.…”

Section: Discussionmentioning

confidence: 99%

Formulation and Stability of a 1% Clarithromycin-Based Topical Skin Cream: A New Option to Treat Buruli Ulcers?

Sebti,

Schweitzer-Chaput,

Cisternino

et al. 2024

Pharmaceuticals

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There are more than 170 known species of non-tuberculous mycobacteria, and some are responsible for serious diseases in people infected with them. One of these is Buruli ulcers, a neglected tropical disease endemic in more than 33 countries and caused by Mycobacterium ulcerans, which infects skin tissue. Treatment consists of a long-term regimen combining the use of oral rifampin with another anti-tuberculosis drug (e.g., clarithromycin). Patients in these countries face difficulties in accessing and adhering to this therapy. This study investigates the feasibility of formulating stable, optimized clarithromycin as a topical cutaneous cream. The cream was formulated, and its stability was evaluated under different storage temperature conditions and using a stability indicator method. The results showed that the clarithromycin cream was stable for at least 60 days, even at extreme temperatures (40 °C). In conclusion, the data presented here demonstrate the stability of a new form of topical cutaneous clarithromycin, which may offer a new approach to the treatment of Buruli ulcers and clarithromycin-sensitive infections.

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Section: Discussionmentioning

confidence: 99%

Formulation and Stability of a 1% Clarithromycin-Based Topical Skin Cream: A New Option to Treat Buruli Ulcers?

Sebti,

Schweitzer-Chaput,

Cisternino

et al. 2024

Pharmaceuticals

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“…Following the dermal application of the cream, liposomes penetrate the SC through intracellular channels to the deeper layer of the epidermal tissue and then to the highly vascularized dermis. Lipids accumulated in the extracellular structure of the epidermis form a route for active ingredient delivery ( Bourdon et al, 2016 ). The present study demonstrated a very good KET permeation from the transdermal vehicle as compared to the ready-to-use commercial gel preparations, which may translate into effective treatment, resulting in a better pharmacological effect.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the in vitro permeation parameters of topical ketoprofen and lidocaine hydrochloride from transdermal Pentravan® products through human skin

et al. 2023

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In the treatment of pain, especially chronic pain, the rule of multimodal therapy applies, based on various painkillers mechanisms of action. The aim of the conducted study was to evaluate the in vitro penetration of ketoprofen (KET) and lidocaine hydrochloride (LH) through the human skin from a vehicle with transdermal properties. The results obtained with the use of the Franz chamber showed statistically significantly higher penetration of KET from the transdermal vehicle as compared to commercial preparations. It was also shown that the addition of LH to the transdermal vehicle did not change the amount of KET permeated. The study also compared the penetration of KET and LH by adding various excipients to the transdermal vehicle. Comparing the cumulative mass of KET that penetrated after the 24-h study, it was observed that the significantly highest permeation was found for the vehicle containing additionally Tinctura capsici, then for that containing camphor and ethanol, and the vehicle containing menthol and ethanol as compared to that containing Pentravan® alone. A similar tendency was observed in the case of LH, where the addition of Tinctura capsici, menthol and camphor led to a statistically significant higher penetration. Adding certain drugs such as KET and LH to Pentravan®, and substances such as menthol, camphor or capsaicin, can be an interesting alternative to administered enteral drugs especially in the group of patients with multiple diseases and polypragmasy.

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“…In addition, hydrophilic petrolatum, anionic cream, and cold cream are official USP ointment bases, and it has been reported that PLO promotes the release of hydrophobic drugs. [16][17][18][19] Therefore, they were selected as the compounding bases in this study. The compositions and preparation of the four compounding bases are provided in the Supplementary Materials.…”

Section: Preparation Of Amh Formulationsmentioning

confidence: 99%

“…Several studies have reported that the PLO promotes the release of hydrophobic drugs. [16][17][18][19] Together with the weak affinity between the poloxamer and amitriptyline, the coexistence of organic and aqueous phases through the structurally well-defined micellar network of phospholipids of PLO, in which low water-soluble amitriptyline can be entrapped within the gel matrix, 26 may facilitate the release of amitriptyline (expressed as AMH) from PLO. 19 The presence of surfactants in the system can impact the solubility of the hydrophobic drug and improve the drug release rate.…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Stability of Extemporaneously Prepared Amitriptyline Hydrochloride Topical Preparations for the Treatment of Neuropathic Pain

2023

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Objective: The aim of this study was to investigate the physicochemical and microbiological stability of extemporaneous amitriptyline hydrochloride (AMH) topical preparations for the treatment of neuropathic pain. Materials and Methods: AMH tablets were triturated to produce fine powders with a mortar and pestle. These powders were levigated and separately incorporated into four compounding bases: hydrophilic petrolatum USP, anionic cream, cold cream USP, and pluronic lecithin organogel (PLO) having the concentration of 2%w/w AMH. Results: In the in vitro release study, the most significant amount of AMH was released from the PLO, followed by cold cream, anionic cream and hydrophilic petrolatum, respectively; therefore, the compounded AMH in cold cream and AMH in PLO were selected for the evaluation of the in vitro permeation and product stability. The permeation of AMH from PLO across human epidermal membrane was significantly greater than that from the cold cream.Product stability was characterized as having no remarkable change in color or texture and AMH remaining in the range of 90–110% of the initial concentration quantified by high-performance liquid chromatography. Compounded AMH in cold cream was stable at 2–8 °C and 30 °C for 60 days, and 40 °C for 30 days, whereas compounded AMH in PLO was stable at 30 °C and 40 °C for 14 days. There was no visible microbial growth in any of the samples. Conclusion: Taken together with the in vitro permeation and product stability studies, the present study suggests that AMH in cold cream could be prepared and used as extemporaneous topical preparations with a beyond-use date of 60 days when kept at 2–8 °C and 30 °C.

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Evaluation of Pentravan ® , Pentravan ® Plus, Phytobase ® , Lipovan ® and Pluronic Lecithin Organogel for the transdermal administration of antiemetic drugs to treat chemotherapy-induced nausea and vomiting at the hospital

Cited by 17 publications

References 40 publications

Formulation and Stability of a 1% Clarithromycin-Based Topical Skin Cream: A New Option to Treat Buruli Ulcers?

Formulation and Stability of a 1% Clarithromycin-Based Topical Skin Cream: A New Option to Treat Buruli Ulcers?

Evaluation of the in vitro permeation parameters of topical ketoprofen and lidocaine hydrochloride from transdermal Pentravan® products through human skin

Stability of Extemporaneously Prepared Amitriptyline Hydrochloride Topical Preparations for the Treatment of Neuropathic Pain

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