PurposeTo evaluate the reduction of patients’ bed rest time after percutaneous renal biopsy (PRB) from 24 to 8 h using the Nursing Outcomes Classification (NOC).MethodsThis was a randomized clinical trial registered with Clinical Trials number NCT04629235. The sample comprised 16 patients in the intervention group and 18 in the control group. In the intervention group, the rest time was modified to 8 h, and afterward, the patients were released to ambulate, whereas the control patients remained at absolute rest for 24 h after PRB according to institutional protocol. All patients were observed for 24 h and evaluated at five time points with the outcomes and indicators of the NOC: before the biopsy, immediately after, at the 8th hour, at the 12th hour, and at the 24th hour after the procedure.ResultsIn the 170 evaluations performed, statistically significant differences were identified in the outcome Comfort status: physical and the indicators “physical well‐being and comfortable position.” None of the complications were related to reduced bed rest time.ConclusionsReducing patients’ bed rest time from 24 to 8 h did not increase complications from PRB, and using the NOC provided a standardized and reliable assessment.Implications for nursing practiceImportant evidence was identified for patient care after PRB, demonstrating the positive impact on patient comfort and the possibility of reducing costs to the institution and the workload of the multidisciplinary team. In addition, these findings may contribute to strengthening the use of NOC in clinical practice, teaching, and research.