Evaluation of Performance of Date Palm Pollen on Urea and Creatinine Levels in Adult Female Rats Exposed to Lead Acetate Intoxication

Salim, Marah

doi:10.7439/ijbar.v6i1.1565

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…This is line with the report of Iteire et al [13] that revealed mild vessel congestion in the liver of rats treated with a high dose of the extract. The observed improved kidney function in rats is attributed to the antioxidant and free radical scavenging properties of PD, which was previously observed in the liver of rats by Al Qarawi et al [14] and Mohamed et al [15,16] It was as also observed by Salim [6] that PD has the ability to counteract the toxic effect of lead acetate associated with improved renal histology and serum concentration of urea and creatinine and as observed by Saafi-Ben et al [7,17], date palm fruit extract significantly reduced lipid peroxidation and restored antioxidant defense enzymes and improved histopathologic changes in kidneys of rats.…”

Section: Discussionsupporting

confidence: 72%

“…Another report by Arshad et al [4] also stated that it had anticancer activities, while the anti-diarrheal activity was demonstrated by Abdulla and Al-Taher [5]. More recently, Salim [6] observed that date palm pollen has the ability to counteract the toxic effects of lead acetate with improved renal histological features, as well as a serum concentration of urea and creatinine. Saafi-Ben et al [7] reported that date palm fruit extract significantly reduced lipid peroxidation and restored antioxidant defense enzymes in the kidney and improved the histopathology changes in the kidney of rats, in which oxidative stress and nephrotoxicity were induced by dimethoate.…”

Section: Introductionmentioning

confidence: 99%

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A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats

Emojevwe¹

2018

Prog Med Sci

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Background: Phoenix dactilifera (PD) has been used as a medicinal remedy for swollen limbs, aching legs, cough, sneezing, and acceleration of hair growth. Although studies have suggested the beneficial aspects of this agent to human health, it is not yet clear of the dosage that may become detrimental. Methods: Twenty adult albino rats divided into four groups of five rats each were used in this experiment. Methanol extract of PD was orally administered at doses of 4, 8, and 16 mg/kg to groups 2, 3, and 4, respectively, while group 1 (control) received distilled water. After 8 hours, blood was collected from the animals for the assessment of packed cell volume, serum urea, creatinine, glucose, potassium, chloride, and sodium. The data generated were expressed as the mean ± standard error of mean. The means were compared with Student’s t-test and analysis of variance with a p-value of 0.05 considered statistically significant. Results: In all parameters analyzed, kidney function was improved only at doses of 4 and 8 mg/kg, which was attributed to the antioxidant and free radical scavenging properties of PD. A higher dose of 16 mg/kg significantly increased the K+ (36.0 ± 4.5/22.6 ± 2.3 mEq/l) and serum urea (32.0 ± 3.8 mg/dl/25.2 ± 1.4 mg/dl) concentrations when compared with the control but other parameters measured were unchanged. These revealed that high doses of PD might impair normal renal functions. Conclusions: It was, therefore, concluded that methanol extract of PD fruit improved kidney functions at doses of 4 and 8 mg/kg and that at 16 mg/kg, PD might be deleterious to the kidney by impairing urea and potassium excretion.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats

Emojevwe¹

2018

Prog Med Sci

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“…Han et al (2020b) reported that exposure of ammonium to chickens at higher concentrations caused a signi cant (P < 0.05) down-regulation in the level of antioxidant enzyme activities such as CAT, GSH-Px, and SOD. The supplementation lead acetate indicated a considerable (p<0.05) rise in creatinine and urea with regarding the untreated group (Salim et al 2015). Elevation in the creatinine level in conducted research is in favor of the results stated by Obi-Ezeani et al (2020).…”

Section: Discussionmentioning

confidence: 67%

Large scale toxicological evaluation of lead acetate in broiler chicken

Ali¹,

Minhas²,

Awan³

et al. 2021

Preprint

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Among heavy metals, lead is one of the very toxic pollutants of the environment. Its accumulating nature in the body makes it a great threat to public health particularly when humans consume lead intoxicated foods like chickens. The main purpose of the conducted research was to elucidate the bioaccumulation of lead in different organs of chickens and its toxicological effects on various organs and biochemical parameters. An experimental study on the effect of lead acetate toxicity in chicks was conducted by orally administration for consecutive thirty days. Thirty-chicks were categorized into A, B, C, D, E, and F groups with lead acetate dose rate 0, 71, 142, 213, and 284 mg/kg body weight, correspondingly. During the experiment, various biochemical parameters (uric acid, GPT, creatinine, ALP, LDH, ASAT, ALT, glutathione, superoxide dismutase) were measured employing commercially available kits. At the end of experimentation, and lead accumulation in liver, kidney and brain was estimated by absorption spectrophotometer. Some biochemical parameters like uric acid, GPT, creatinine, ALP, LDH, AST, and ALT were increased while the level of glutathione and superoxide dismutase, was found to be decreased after exposure to lead acetate. In present study, the pattern of metal accumulation in different organs directly related with concentration of metal. The order of metal accumulation in organs is; liver > kidney > brain. In the present study, supplementation of lead acetate has affected the exposed chicken. Mostly the blood profile and chemistry are perturbed. These effects might be due to the accumulation of lead in the brain, kidneys, and liver which may result in neurotoxicity, nephrotoxicity, and hepatotoxicity. To refine such outcomes, further studies in the future are recommended.

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“…Literature data on the effects of acute Pb exposure triggering oxidative stress in the kidney of animals are rare. The administration of lead acetate showed a significant (p<0.05) increase in urea and creatinine concentration compared with other groups [ 53 ]. Sharma and Singh [ 54 ] have recently reported that 24 h exposure to 10 and 150 mg/kg BW of Pb acetate induced increased in renal thiobarbituric acid reactive substances (TBARS) content that acts as an indicator of lipid peroxidation, as well as SOD and CAT activities in kidney of Balb-c mice.…”

Section: Introductionmentioning

confidence: 99%

The detrimental effects of lead on human and animal health

et al. 2016

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Lead, a chemical element in the carbon group with symbol Pb (from Latin: Plumbum, meaning “the liquid silver”) and has an atomic number 82 in the periodic table. It was the first element that was characterized by its kind of toxicity. In animal systems, lead (Pb) has been incriminated in a wide spectrum of toxic effects and it is considered one of the persistent ubiquitous heavy metals. Being exposed to this metal could lead to the change of testicular functions in human beings as well as in the wildlife. The lead poising is a real threat to the public health, especially in the developing countries. Accordingly, great efforts on the part of the occupational and public health have been taken to curb the dangers of this metal. Hematopoietic, renal, reproductive, and central nervous system are among the parts of the human body and systems that are vulnerable toward the dangers following exposure to high level of Pb. In this review, we discussed the massive harmful impact that leads acetate toxicity has on the animals and the worrying fact that this harmful toxicant can be found quite easily in the environment and abundance. Highlighting its (Pb) effects on various organs in the biological systems, its economic, as well as scientific importance, with the view to educate the public/professionals who work in this area. In this study, we focus on the current studies and research related to lead toxicity in animals and also to a certain extent toward human as well.

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Evaluation of Performance of Date Palm Pollen on Urea and Creatinine Levels in Adult Female Rats Exposed to Lead Acetate Intoxication

Cited by 7 publications

References 10 publications

A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats

A sub-acute toxicity study to assess the effects of methanol extract of date palm fruit on kidney functions in adult Wistar rats

Large scale toxicological evaluation of lead acetate in broiler chicken

The detrimental effects of lead on human and animal health

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