Evaluation of Periodontitis as a Risk for Preterm Birth among Preeclamptic and Non–Preeclamptic Pregnant Women – A Case Control Study

Pattanashetti, Jyoti I; Nagathan, Veeresh M; Rao, Subramaniam M

doi:10.7860/jcdr/2013/6497.3308

Cited by 9 publications

(11 citation statements)

References 28 publications

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“…However, studies conducted by Nabet et al3 and Pattanashetti et al35 found a strong association between PD and induced PTB due to preeclampsia. Our findings are at odds with those of studies performed in Iran and Italy by Abati et al1 and Yaghini et al36, who did not report this association.…”

Section: Discussionmentioning

confidence: 93%

The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study

Gesase¹,

Miranda‐Rius²,

Brunet‐Llobet³

et al. 2018

Afr H. Sci.

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Section: Discussionmentioning

confidence: 93%

The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study

Gesase¹,

Miranda‐Rius²,

Brunet‐Llobet³

et al. 2018

Afr H. Sci.

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“…Further evidence for an oral-placental axis involved in PTB includes the identification of common oral pathogens (e.g. Fusobacterium nucleatum , Dialister spp., Prevotella spp., and Porphyromonas gingivalis ) in the placenta of women with periodontal disease [ 84 , 85 ], which is associated with increased risk of PTB [ 84 , 86 , 87 ]. However, interventions that improve periodontal health during pregnancy do not prevent PTB [ 88 – 90 ] and many bacterial species that were historically considered to be limited to the oral cavity are now recognised as being commonly observed members of the vaginal niche.…”

Section: Evidence For An Oral-placental Microbiome Axis In Preterm Bimentioning

confidence: 99%

The pregnancy microbiome and preterm birth

et al. 2020

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Preterm birth is a global health concern and continues to contribute to substantial neonatal morbidity and mortality despite advances in obstetric and neonatal care. The underlying aetiology is multi-factorial and remains incompletely understood. In this review, the complex interplay between the vaginal microbiome in pregnancy and its association with preterm birth is discussed in depth. Advances in the study of bacteriology and an improved understanding of the human microbiome have seen an improved awareness of the vaginal microbiota in both health and in disease.

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“…12 Many researchers like Offenbacher et al, Lin et al and Boggess et al have suggested the association of periodontitis with preeclampsia by relocation of periodontal toxins along with infective bacteria to chorio-amniotic membranes. 5,13 It has also been claimed that even preeclampsia aggravates the preformed chronic periodontitis 14 , thus this pertinent linkage of periodontitis and preeclampsia has also been announced as a two-way street. 5 Talking about the pathogenesis of this relation, a group of researchers explained that as in gestation the immuneinflammatory responses of the body have usually been increased because of the hormonal shift that ultimately lead to enhance inflammatory pathologies like periodontitis.…”

Section: Discussionmentioning

confidence: 99%

IL-12 Levels in Pregnancies with Preeclampsia and Periodontitis

Sadiqa¹,

Cheema²

2019

IJCMR

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Introduction: Periodontal pathology has become a momentous concern of public health due to its increasing prevalence in adults around the globe. Study was aimed to compare serum IL-12 p-70 levels in preeclampted and nonpreeclamptic women and to observe serum IL-12 p-70 levels in preeclamptic with and without chronic periodontitis. Material and methods: It was a Longitudinal Cohort Study. The sampled population belonged to Narowal District of Punjab, Pakistan. Duration of the study was from June 2016 to February 2018. All pregnant subjects' aged in-between 18-34 years were participated though convenience sampling and consented. Out of total 73 subjects, 33 were with healthy periodontium (6 preeclamptic and 27 normotensives) and 40 were with chronic periodontitis (6 preeclamptics and 34 normotensives). Sampling was performed in two phases; First when all subjects were in 2 nd trimester and second when all were in postpartum period. Periodontal status was assessed by CPITN (Community Periodontal Index for Treatment Need) probing technique and for preeclampsia, monthly blood pressure profile of each participant was taken by her doctor. Serum estimation of IL-12 p-70 was confirmed through sandwich ELIZA technique. Microsoft Excel and Minitab were used for data analysis. Results: Normotensives with healthy periodontium showed 17.4% high serum IL-12 p70 (pg/ml) in antepartum than postpartum. Similarly preeclamptics with healthy periodontium exhibited 13.4% high serum IL-12 p70 in antepartum than postpartum. While normotensives with periodontitis displayed 10% high serum IL-12 p70 in postpartum than antepartum. Preeclamptics with periodontitis exhibited 17.4% high serum IL-12 p70 in postpartum than antepartum. Conclusion: Preeclampsia and chronic periodontitis both decrease serum IL-12 p-70 levels in antepartum and puerperium.

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Evaluation of Periodontitis as a Risk for Preterm Birth among Preeclamptic and Non–Preeclamptic Pregnant Women – A Case Control Study

Cited by 9 publications

References 28 publications

The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study

The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study

The pregnancy microbiome and preterm birth

IL-12 Levels in Pregnancies with Preeclampsia and Periodontitis

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