Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia

Legband, Nathan; Feshitan, Jameel A.; Borden, Mark A.; Terry, Benjamin S.

doi:10.1109/tbme.2015.2388611

Cited by 27 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…255,256,257,258 Moreover, the opportunity exists currently to further test the effects of supplemental O 2 ; more modern standards of clinical trials such as establishing dose/response, effects of treatment duration, minimum dosing necessary etc. should surely be attempted as a simple yet potentially effective intervention.…”

Section: Potential Drug Targets Of Important Placental Pathways Imentioning

confidence: 99%

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Ilekis

Tsilou

Fisher

et al. 2016

American Journal of Obstetrics and Gynecology

237

167

View full text Add to dashboard Cite

Although much progress is being made in understanding the molecular pathways in the placenta involved in the pathophysiology of pregnancy related disorders, a significant gap exists in utilizing this information for developing new drug therapies to improve pregnancy outcome. On March 5–6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a two day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap. Particular emphasis was given in the identification of important molecular pathways that could serve as drug targets and the advantages and disadvantages of targeting these particular pathways. This article is a summary of the proceedings of this workshop. A broad number of topics were covered ranging from basic placental biology to clinical trials. This included research in the basic biology of placentation, such as trophoblast migration and spiral artery remodeling, and trophoblast sensing and response to infectious and non-infectious agents. Research findings in these areas will be critical for formulating developing future treatments and developing therapies for the prevention of a number of pregnancy disorders of placental origin including preeclampsia, fetal growth restriction, and uterine inflammation. Research was also presented summarizing ongoing clinical efforts in the U.S. and in Europe testing novel interventions for preeclampsia and fetal growth restriction, including agents such as oral arginine supplementation, sildenafil, pravastatin, gene therapy using virally-delivered vascular endothelial growth factor, and oxygen supplementation therapy. Strategies were also proposed to improve fetal growth by enhancing nutrient transport to the fetus by modulating their placental transporters, as well as targeting placental mitochondrial dysfunction and oxidative stress to improve placental health. The roles of microRNAs and placental-derived exosomes, as well as messenger RNAs, were also discussed in the context of their use for diagnostics and as drug targets. The workshop discussed the aspect of safety and pharmacokinetic profiles of potential existing and new therapeutics that will need to be determined especially in the context of the unique pharmacokinetic properties of pregnancy, as well as the hurdles and pitfalls of translating research findings into practice. The workshop also discussed novel methods of drug delivery and targeting during pregnancy using macromolecular carriers, such as nanoparticles and biopolymers, to minimize placental drug transfer and hence fetal drug exposure. In closing, a major theme that developed from the workshop was that the scientific community needs to change their thinking of the pregnant women and her fetus as a vulnerable patient population for which drug development should be avoided, but rather thought of as a deprived population in need of more effective therapeutic interventions.

show abstract

Section: Potential Drug Targets Of Important Placental Pathways Imentioning

confidence: 99%

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Ilekis

Tsilou

Fisher

et al. 2016

American Journal of Obstetrics and Gynecology

237

167

View full text Add to dashboard Cite

show abstract

“…Therefore, we aimed to identify other methods to supply oxygen promptly, particularly when encountered with above situations, in order to facilitate resuscitation, thereby providing additional time for tracheotomy. Previous studies have demonstrated that oxygen supply via peritoneum is feasible by direct abdominal ventilation or intraperitoneal infusion with oxygen carriers [5,8,12,13,[15][16][17][18][19] .However, these methods are complex and cannot be performed immediately; therefore, they are not suitable for emergency resuscitation in the operating room.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it may be used for extra-pulmonary oxygenation [11] . Previously, peritoneal oxygenation has been shown to moderately increase systemic arterial partial pressure of oxygen in rabbit, rat, and pig models [5,[12][13][14] via direct abdominal ventilation or intra-peritoneal infusion with oxygen carriers, such as perfluorocarbon, red blood cells, or oxygen micro-bubbles [5,8,12,13,[15][16][17][18][19] .Hence, peritoneal oxygenation has long been desired for extra-pulmonary oxygenation, as it is easy to perform, compared to use of an extracorporeal circuit.…”

mentioning

confidence: 99%

Effect of Oxygen Pneumoperitoneum on Hypoxia Tolerance in Beagle Dogs: An Experimental Study

Cao¹,

Zhang²,

Wang³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: When an airway is difficult to manage during surgery, it can be fatal. Thus, peritoneum oxygenation may be theoretically feasible as an alternative route to supply oxygen. The objective of this study is to investigate whether artificial oxygen pneumoperitoneum combined with abdominal lifting and compression is effective in systemic oxygenation and hypoxia tolerance in a beagle dog model of asphyxia. Methods: Latin Square design was adopted. Eight adult female beagle dogs were divided into four subgroups; they received four treatments in sequence in four sessions at 1-week intervals. The pre-treatment procedures included general anesthesia and a pause in ventilation to establish an asphyxia model. Each subgroup was subjected to the treatments as follows: negative control(A), artificial oxygen pneumoperitoneum(B), artificial oxygen pneumoperitoneum combined with abdominal lifting and compression from the 1st minute after asphyxia(C), or the same as C but starting the method from the 5th minute(D). Vital signs, important organ functions, and arterial blood gas were monitored. Hypoxia tolerance was assessed by the asphyxia time (from pause to restoration of ventilation) and PaO2 levels at 0, 6, 7, 8, 9, and 10 minutes after asphyxia onset. Results: The physiological status of the beagles was approximately identical before each experiment and the treatments did not aggravate the impact of hypoxia. The asphyxia time for treatments A, B, C, and D were 9.65 ± 1.10 min, 11.18± 0.50min, 11.45 ± 0.79min, and 11.70 ± 0.99min, respectively; the time was lengthened in treatments B, C, and D, compared with that in treatment A (P<0.01). Moreover, PaO2 levels at 9 and 10 min were higher in treatments B, C, and D than in treatment A (P<0.01). Conclusions: Artificial oxygen pneumoperitoneum combined with abdominal lifting and compression appears safe and effective and may improve systemic oxygenation and enhance hypoxia tolerance.

show abstract

“…Various characterization techniques have been applied to characterize MNBs. Optical and fluorescence microscopy can reveal micron-sized bubbles, while dynamic light scattering (DLS) and other optical particle counters can be used to determine the size of the nanobubbles [8,10,13,50,72]. SEM and TEM techniques have been used to visualize MNBs [12].…”

Section: Characterization Techniques For Mnbsmentioning

confidence: 99%

“…Photodynamic therapy (PDT) is another treatment mechanism that is oxygen-dependent for the generation of reactive oxygen species (ROS), and the increased oxygen level enhances the effectiveness of PDT [6,7]. Hypoxemia or low blood oxygen level occurs in patients suffering from severe lung injury, airway obstruction, reduced cardiac output, or any critical illness, and hypoxemia is responsible for an increased mortality rate [2,8,9]. Hypoxemia may cause cardiac arrest or organ damage and neurological complexities owing to low oxygen supply to the brain [2,10].…”

Section: Introductionmentioning

confidence: 99%

Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

Khan¹,

Hwang²,

Lee³

et al. 2018

Preprint

View full text Add to dashboard Cite

Microbubbles and nanobubbles can be prepared using various shells, such as phospholipids, polymers, proteins, and surfactants. They are echogenic and can be used as contrast agents for ultrasonic and photoacoustic imaging. These bubbles can be engineered in various sizes as vehicles for gas and drug delivery applications with novel properties and flexible structures. Hypoxic areas in tumors develop owing to an imbalance of oxygen supply and demand. In tumors, hypoxic regions have shown more resistance to chemotherapy, radiotherapy, and photodynamic therapies. The efficacy of photodynamic therapy depends on the availability of oxygen in the tumor to generate reactive oxygen species. Micro/nanobubbles have been shown to reverse hypoxic conditions and increase tissue oxygen levels. This review summarizes the synthesis methods and shell compositions of micro/nanobubbles and methods deployed for oxygen delivery. In addition, the shortcomings and prospects of engineering micro/nanobubbles are discussed for their potential use in photodynamic therapy.

show abstract

Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia

Cited by 27 publications

References 41 publications

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Effect of Oxygen Pneumoperitoneum on Hypoxia Tolerance in Beagle Dogs: An Experimental Study

Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

Contact Info

Product

Resources

About