Evaluation of Peritumoral Edema in the Delineation of Radiotherapy Clinical Target Volumes for Glioblastoma

Chang, Eric L.; Akyürek, Serap; Avalos, T; Rebueno, Neal; Spicer, Chris; Garcia, J.; Famiglietti, Robin; Allen, Pamela K.; Chao, K.S. Clifford; Mahajan, Anita; Woo, Shiao Y.; Maor, Moshe

doi:10.1016/j.ijrobp.2006.12.009

Cited by 200 publications

(167 citation statements)

References 19 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…The overall survival in this sequential cohort of patients was similar to that seen in the prospective study by Stupp et al [2,3] and reports by other individual institutions using different approaches to contouring [11,12,14,15].…”

Section: Discussionsupporting

confidence: 87%

“…Through high-quality image fusion, improved dosimetry and more accurate treatment delivery many institutions have adapted protocols to permit reduction of the dose given to normal tissue [11][12][13]. The aim of this study was to evaluate the pattern of relapse following RT-TMZ using conformal radiotherapy to aid the development of a protocol using image-guided intensity-modulated radiotherapy (IMRT).…”

Section: Advances In Knowledgementioning

confidence: 99%

See 1 more Smart Citation

Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide

Sherriff¹,

Tamangani²,

Senthil³

et al. 2013

BJR

116

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

Section: Advances In Knowledgementioning

confidence: 99%

Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide

Sherriff¹,

Tamangani²,

Senthil³

et al. 2013

BJR

116

View full text Add to dashboard Cite

“…Chang et al reported in their study that there is no obvious relationship between peritumoral edema and recurrence pattern. Target delineation with 2 cm initial margin and 1 cm boost margin without including edema seems not to alter the typical GBM pattern of failure (23). In our study, recurrences were not in the 150 cGy region, which supports this study.…”

Section: Resultssupporting

confidence: 86%

The Helical Tomotherapy Experience on Radiotherapy of Glioblastoma Multiforme

Küçüktülü¹

2018

Akd Med J

View full text Add to dashboard Cite

Objective: The standard treatment of Glioblastome Multiforme (GBM) is surgical resection followed by chemoradiotherapy and adjuvant temozolamide. Intensity Modulated Radiotherapy (IMRT) offer an advantage in terms of reducing the dose to critical normal structures and a reduced dose to the normal brain. It also offers application of Simultaneous Integrated Boost (SIB). Material and Methods:Among our 12 patients, 7 had a diagnosis of GBM whereas 3 of them were anaplastic oligoastrocytoma and 2 of them were diagnosed radiologically as high-grade glial tumor. In all patients, 60 Gy SIB-IMRT with concomitant Temozolomide was used. Results:In post treatment Magnetic Resonance Imaging (MRI), 8 patients had no recurrence whereas 2 patients showed partial response and in 2 patients there was no response at all. After a median follow-up period of 12 months, 3 patients survived disease free, and 9 patients were expired. The overall survival was 14.8 months. Median progression free survival was 4.4 months. The mean dose received by the brain stem was 12.90 Gy and 12.72 Gy for the optic chiasm. Conclusion:High doses can be given while protecting critical tissues with SIB-IMRT.

show abstract

“…Fox et al [7] studied the GTV on FDG-PET/CT registered images of lung cancer; they documented intra-and interobserver concordance rates of 70% and 71%, respectively. Regarding brain tumors, the central tumor core, due to its visibility on contrast-enhanced MR images, is now accepted as an indicator of the GTV [17] . To utilize brain MR images for GTV contouring, previous studies suggested the value of the registration of MR images to planning-CT images; the use of MR/CT-registered images rather than hard copies of MR images reduced interobserver variability [3,4] .…”

Section: Discussionmentioning

confidence: 99%

Double reading for gross tumor volume assessment in radiotherapy planning

Murakami

Hirai

Toya

et al. 2012

JST

View full text Add to dashboard Cite

Background/Objective: The precise definition of the gross tumor volume (GTV) that takes into account intra-and interobserver variability is necessary for high-precision radiotherapy (RT) techniques. The purpose of this study was to demonstrate the practical GTV assessment by a "double reading" approach.Methods: Pretreatment magnetic resonance (MR) imaging, including the post-contrast 3D magnetization-prepared rapid-gradient echo (MP-RAGE) sequence (section thickness 1.0 mm) was performed on a 3T superconducting imager in 50 patients with glioblastoma. MR images were transferred to a RT planning system (RTPS) that provides many opportunities for GTV contouring, e.g., at diagnosis, surgical navigation, and RT deliberations. Independent 2 observers preliminarily contoured the GTV on MR images. After planning-CT scanning, CT images with a 1.0 mm slice interval were transferred to the RTPS, registered with the diagnostic images, and then the preliminarily-contoured strictures were copied onto the CT images and used for GTV assessment. The practical GTV on the planning CT was determined by integrating the interpretations and adding information on postoperative changes. The interobserver variability in GTV contouring was assessed by Bland-Altman analysis and the concordance index.Results: There was substantial interobserver variability in GTV contouring (95% limits of agreement: -29.4%, 16.8%). The mean interobserver concordance rate for the GTV was 82.1% (range 56.5-91.2%). The practical GTVs were significantly larger than the preliminarily-contoured GTVs by both observers (p < 0.01).Conclusions: Considering interobserver variability, "double reading" is necessary for practical GTV assessment. This approach for volume assessment may facilitate the standardization of treatments, not only of RT but also of surgery and chemotherapy.

show abstract

Evaluation of Peritumoral Edema in the Delineation of Radiotherapy Clinical Target Volumes for Glioblastoma

Cited by 200 publications

References 19 publications

Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide

Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide

The Helical Tomotherapy Experience on Radiotherapy of Glioblastoma Multiforme

Double reading for gross tumor volume assessment in radiotherapy planning

Contact Info

Product

Resources

About