Evaluation of Perylene Bisimide‐Based Ru^II and Ir^III Complexes as Photosensitizers for Photodynamic Therapy

Abstract

Abstract:The synergistic action of a photosensitizer (PS), light, and oxygen is exploited in photodynamic therapy (PDT)

Crystal structure, physicochemical properties, Hirshfeld surface analysis and antibacterial activity assays of transition metal complexes of 6-methoxyquinoline

“…This decrease is probably associated with the life time excited triplet diminution which could be attributed to bonding and no bonding interactions 38,39 . However, the Φ Δ values found for the complexes are similar or even higher than those of some reported transition metal complexes of Co(II), Ni(II), Cu(II) , Zn(II) and Ru(II) complexes with different ligands (Φ Δ = 0.32, 0.27, 0.30, 0.40 and 0.29, respectively) 21,40,41 .…”

Novel Cyclometalated Fe(II) Complex with NCN Pincer and BODIPY‐Appended 4'‐Ethynyl‐2,2':6',2”‐terpyridine as Mitochondria‐Targeted Photodynamic Anticancer Agents

“…Light doses were evaluated with a Gigahertz Optic X1‐1 optometer. The light doses employed in this work are comparable to those employed for activation of other metal‐based phototoxic compounds (2‐11.5 J cm ‐2 at 400–600 nm) …”

Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy

“…Reports of “half‐sandwich” cyclopentadienyl Ir III complexes as PDT agents are rare as these types of compounds are mostly non‐emissive. Gasser and colleagues recently reported a perylenebisimide‐based Ir III complex as near‐IR‐emitting photosensitizer for PDT application (Scheme ) . Complex 42 displays interesting spectroscopic characteristics, such as a highly populated triplet state and extremely long emission lifetimes (33 μs in degassed dichloromethane), along with a high singlet‐oxygen quantum yield (0.85 in acetonitrile).…”