Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Faccia, Paula Andrea; Pardini, Francisco Martín; Amalvy, Javier Ignacio

doi:10.3144/expresspolymlett.2015.52

Cited by 20 publications

(9 citation statements)

References 54 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This analysis is in agreement with those of other authors in polymer systems doped with Rhodamine 6G 28,29 , and allows us to corroborate that rhodamine 6G is present in the polymer matrix as mentioned in section 3.3, and infer that interacts with said matrix by hydrogen bonds and dipole-dipole interactions. Figure 8 shows the images obtained from three experimental setups.…”

Section: Xrd Measurementssupporting

confidence: 92%

“…A new band around 1604 cm -1 was observed after the addition of Rhodamine 6G, as well as a shift of the band positioned at 1655 cm -1 to 1650 cm -1 (Figure 7A and B). These results can be attributed to the presence of the xanthene ring 28,29 , and probably to the hydrogen interactions thereof with the polymer matrix. In the region between 1502 and 1580 cm -1 are included the vibrational modes of the xanthene ring coupled with ethylamine, methyl and phenyl groups ( Figure 7B) 28,29,30 .…”

Section: Xrd Measurementsmentioning

confidence: 94%

See 1 more Smart Citation

Synthesis and Characterization of Fluorescent PVA/PVAc-Rodhamine Microspheres

et al. 2019

View full text Add to dashboard Cite

Fluorescent polymeric microspheres are used in a wide range of biomedical and technological applications, including blood flow determination, screening, flow visualization, flow tracing, medical imaging, fluorescence microscopy and flow cytometry among others. Rhodamine 6G (R6G) is a lipophilic cationic dye, which is among the most stable organic fluorophores, and with a high quantum yield in fluorescence (absorption and emission) in the visible range (500-600 nm). It is mainly applied in laser technology, and also in fluorescent bioimage. In this work we present an efficient synthesis route to obtain Polyvinyl Alcohol/Polyvinyl Acetate (PVA/PVAc) spherical microparticles containing Rhodamine 6G in a concentration sufficient to exploit their fluorescent properties. The synthesis method comprises the suspension polymerization of Vinyl acetate (VAc) monomer in the presence of Rhodamine, followed by saponification. Microspheres loaded with 1.9% w / w of Rhodamine 6G were obtained. They presented good sphericity and a size distribution in the range of 20 to 1550 microns. The fluorescence intensity of the microspheres was measured by UV-Vis and fluorescence spectroscopy, and detected using an image-based experimental setup, respectively. The results obtained with these methodologies showed that our microspheres exhibit fluorescence and that they are quite detectable in water flows. However, the response of UV-Visible fluorescence and absorbance was affected by the presence of the PVA / PVAc polymer matrix.

show abstract

Section: Xrd Measurementssupporting

confidence: 92%

Section: Xrd Measurementsmentioning

confidence: 94%

Synthesis and Characterization of Fluorescent PVA/PVAc-Rodhamine Microspheres

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Various other pH-responsive polymers have also been investigated for ophthalmic applications, including chitosan, a pH-responsive polymer which also exhibits mucoadhesive [78] and permeation-enhancing [79,80] properties, in combination with the thermoresponsive polymer (pluronic F-127) [81]. Others include; polyvinylacetal diethylaminoacetate [82] and poly(2-hydroxyethylmethacrylate-co-2-(diisopropylamino)ethyl methacrylate) [83].…”

Section: Ph-responsive Polymers Used In Ophthalmologymentioning

confidence: 99%

Ophthalmic gels: Past, present and future

Al-Kinani

Zidan

El-Said

et al. 2018

Advanced Drug Delivery Reviews

150

100

View full text Add to dashboard Cite

Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based ones with intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes. Novel applications and design of contact lenses and intracanalicular delivery devices along with the move towards integrating gels into various drug delivery devices like intraocular pumps, injections and implants has the potential to reduce comorbidities caused by glaucoma, corneal keratopathy, cataract, diabetic retinopathies and age-related macular degeneration. This review describes ophthalmic gelling systems with emphasis on mechanism of gel formation and application in ophthalmology. It provides a critical appraisal of the techniques and methods used in the characterization of ophthalmic preformed gels and in situ gelling systems along with a thorough insight into the safety and biocompatibility of these systems. Newly developed ophthalmic gels, hydrogels, preformed gels and in situ gelling systems including the latest in the area of stimuli responsive gels, molecularly imprinted gels, nanogels, 3D printed hydrogels; 3D printed devices comprising ophthalmic gels are covered. Finally, new applications of gels in the production of artificial corneas, corneal wound healing and hydrogel contact lenses are described.

show abstract

“…The merits of the pHEMA bioreagent include availability, cost efficiency, minimal preparation requirements, and guaranteed safety. The versatility of this chemical has enabled it to be employed in various applications in the form of a hydrogel including soft contact lenses, membrane dialyzers, wound dressings, testicular prostheses, and vocal cord prosthesis [13] , [14] , [15] , [16] , [17] , [18] , [19] . The chemical pHEMA in a non-hydrogel form is a promising antifouling agent with easy applicability.…”

Section: Introductionmentioning

confidence: 99%

Improving chondrocyte harvests with poly(2-hydroxyethyl methacrylate) coated materials in the preparation for cartilage tissue engineering

Harata

Watanabe

Nagata³

et al. 2017

Regenerative Therapy

View full text Add to dashboard Cite

Remarkable advances have been made in cartilage regenerative medicine to cure congenital anomalies including microtia, tissue defects caused by craniofacial injuries, and geriatric diseases such as osteoarthritis. However, those procedures require a substantial quantity of chondrocytes for tissue engineering. Previous studies have required several passages to obtain sufficient cell numbers for three-dimensional and monolayer cultures. Thus, our objective was to improve the quantity of chondrocytes that can be obtained by examining an anti-fouling polyhydrophilic chemical called poly(2-hydroxyethyl methacrylate) (pHEMA). To determine the effectiveness of the chemical, pHEMA solution was applied via dip-coating to centrifuge tubes, serological pipettes, and pipette tips. The cell quantity obtained during standard cell culturing and passaging procedures was measured alongside non-coated materials as a control. A significant 2.2-fold increase of chondrocyte yield was observed after 2 passages when pHEMA was applied to the tubes compared to when non-coated tubes were utilized. The 3-dimensional chondrocyte pellets prepared from the respective cell populations and transplanted into nude mice were histologically and biochemically analyzed. No evidence of difference in matrix production for in vitro and in vivo cultures was found as well as similar proliferation rates and colony formation abilities. The use of pHEMA provides a powerful alternative method for expanding the quantity of chondrocytes harvested and handled during cell isolation and passaging to enhance cartilage tissue engineering.

show abstract

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Cited by 20 publications

References 54 publications

Synthesis and Characterization of Fluorescent PVA/PVAc-Rodhamine Microspheres

Synthesis and Characterization of Fluorescent PVA/PVAc-Rodhamine Microspheres

Ophthalmic gels: Past, present and future

Improving chondrocyte harvests with poly(2-hydroxyethyl methacrylate) coated materials in the preparation for cartilage tissue engineering

Contact Info

Product

Resources

About