Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine

Li, Boning; Zhang, Lu; Xie, Yonggang; Lei, Lei; Qu, Wenjie; Sui, Long

doi:10.1016/j.reth.2022.10.001

Regenerative Therapy

2022

DOI: 10.1016/j.reth.2022.10.001

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Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine

Boning Li

Lu Zhang

Yonggang Xie

et al.

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2024

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Cited by 4 publications

References 45 publications

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Chen,

Li,

Zheng

et al. 2024

Exploration

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Scaffold‐based tissue engineering provides an efficient approach for repairing uterine tissue defects and restoring fertility. In the current study, a novel trilayer tissue engineering scaffold with high similarity to the uterine tissue in structure was designed and fabricated via 4D printing, electrospinning and 3D bioprinting for uterine regeneration. Highly stretchable poly(l‐lactide‐co‐trimethylene carbonate) (PLLA‐co‐TMC, “PTMC” in short)/thermoplastic polyurethane (TPU) polymer blend scaffolds were firstly made via 4D printing. To improve the biocompatibility, porous poly(lactic acid‐co‐glycolic acid) (PLGA)/gelatin methacryloyl (GelMA) fibers incorporated with polydopamine (PDA) particles were produced on PTMC/TPU scaffolds via electrospinning. Importantly, estradiol (E2) was encapsulated in PDA particles. The bilayer scaffolds thus produced could provide controlled and sustained release of E2. Subsequently, bone marrow derived mesenchymal stem cells (BMSCs) were mixed with gelatin methacryloyl (GelMA)‐based inks and the formulated bioinks were used to fabricate a cell‐laden hydrogel layer on the bilayer scaffolds via 3D bioprinting, forming ultimately biomimicking trilayer scaffolds for uterine tissue regeneration. The trilayer tissue engineering scaffolds thus formed exhibited a shape morphing ability by transforming from the planar shape to tubular structures when immersed in the culture medium at 37°C. The trilayer tissue engineering scaffolds under development would provide new insights for uterine tissue regeneration.

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Chen,

Li,

Zheng

et al. 2024

Exploration

View full text Add to dashboard Cite

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3D printed gelatin/PTMC core/shell scaffolds with NIR laser-tuned drug/biomolecule release for cancer therapy and uterine regeneration

Chen,

Lai,

Chen

et al. 2024

International Journal of Biological Macromolecules

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Intrauterine infusion of platelet‐rich plasma improves fibrosis by transforming growth factor beta 1/Smad pathway in a rat intrauterine adhesion model

Yang,

Zhang,

Fang

et al. 2024

Reproductive Biology

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Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine

Cited by 4 publications

References 45 publications

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

3D printed gelatin/PTMC core/shell scaffolds with NIR laser-tuned drug/biomolecule release for cancer therapy and uterine regeneration

Intrauterine infusion of platelet‐rich plasma improves fibrosis by transforming growth factor beta 1/Smad pathway in a rat intrauterine adhesion model

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