Evaluation of photocytotoxicity liposomal form of furanocoumarins Sosnowsky's hogweed

Kulikov, Oleg A.; Ageev, Valentin P.; Brodovskaya, Ekaterina P.; Шляпкина, Василиса Игоревна; Petrov, P. S.; Zharkov, Mikhail N.; Yakobson, Denis E.; Маев, И. В.; Sukhorukov, Gleb B.; Pyataev, N. A.

doi:10.1016/j.cbi.2022.109880

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…MFCs are mostly lipophilic and therefore have limited water solubility, which reduces their biological potential. On the other hand, as lipophilic substances, MFC diffuse well into the cell [27]. There are few studies concerning bioavailability of MFCs available, and there is still need to profoundly study the behavior of these molecules in the biological fluids of the body and membrane permeability investigations.…”

Section: Bioavaiability Studies Of Mfcsmentioning

confidence: 99%

Methoxyfuranocoumarins of Natural Origin–Updating Biological Activity Research and Searching for New Directions—A Review

Bartnik

2024

CIMB

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Plant secondary metabolites, including furanocoumarins, have attracted attention for decades as active molecules with therapeutic potential, especially those occurring in a limited number of species as evolutionarily specific and chemotaxonomically important. The most famous methoxyfuranocoumarins (MFCs), bergapten, xanthotoxin, isopimpinellin, phellopterin, byakangelicol, byakangelicin, isobergapten, pimpinellin, sphondin, as well as rare ones such as peucedanin and 8-methoxypeucedanin, apaensin, cnidilin, moellendorffiline and dahuribiethrins, have recently been investigated for their various biological activities. The α-glucosidase inhibitory activity and antioxidant potential of moellendorffiline, the antiproliferative and proapoptotic properties of non-UV-activated bergapten and xanthotoxin, the effect of MFC on the activity of tyrosinase, acetyl- and butylcholinesterase, and the role of these compounds as adjuvants in anticancer and antibacterial tests have been confirmed. The anticonvulsant effects of halfordin, the antidepressant effects of xanthotoxin, and the antiadipogenic, neuroprotective, anti-amyloid-β, and anti-inflammatory (via increasing SIRT 1 protein expression) properties of phellopterin, as well as the activity of sphondin against hepatitis B virus, have also attracted interest. It is worth paying attention to the agonistic effect of xanthotoxin on bitter taste receptors (TAS2Rs) on cardiomyocytes, which may be important in the future treatment of tachycardia, as well as the significant anti-inflammatory activity of dahuribiethrins. It should be emphasized that MFCs, although in many cases isolated for the first time many years ago, are still of great interest as bioactive molecules. The aim of this review is to highlight key recent developments in the study of the diverse biological activities of MFCs and attempt to highlight promising directions for their further research. Where possible, descriptions of the mechanisms of action of MFC are provided, which is related to the constantly discovered therapeutic potential of these molecules. The review covers the results of experiments from the last ten years (2014–2023) conducted on isolated natural cMFCs and includes the activity of molecules that have not been activated by UV rays.

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Section: Bioavaiability Studies Of Mfcsmentioning

confidence: 99%

Methoxyfuranocoumarins of Natural Origin–Updating Biological Activity Research and Searching for New Directions—A Review

Bartnik

2024

CIMB

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“…Among them, furan coumarins can be divided into linear furan coumarins and angular furans depending on the position of the fusion, linear furan coumarins are synthesized from the C-6 isopentene group and the C-7 hydroxyl ring to form the furan ring, the structure of the furan ring, benzene ring and ɑ-pyrone ring is located in a straight line, hence the name linear furan coumarins (Bruni et al, 2019;Kitamura, Kohtani, & Nakagaki, 2005;Kulikov et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Coumarins are lactones with the basic structure of benzoɑ‐pyrone and can be broadly grouped into four major groups according to the substituents and benzene rings on the parent nucleus of coumarins, namely, simple coumarins, furanocoumarins, pyranocoumarins, and other coumarins (Ben Salem, Jabrane, Harzallah‐Skhiri, & Ben Jannet, 2013). Among them, furan coumarins can be divided into linear furan coumarins and angular furans depending on the position of the fusion, linear furan coumarins are synthesized from the C‐6 isopentene group and the C‐7 hydroxyl ring to form the furan ring, the structure of the furan ring, benzene ring and ɑ‐pyrone ring is located in a straight line, hence the name linear furan coumarins (Bruni et al, 2019; Kitamura, Kohtani, & Nakagaki, 2005; Kulikov et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Zhong

et al. 2022

Phytotherapy Research

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Xanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF‐κB, MAPK, JAK/STAT, Nrf2/HO‐1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in‐depth studies are needed to determine the clinical efficacy of XAT.

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Comparative Study of the Photocytotoxicity of Two Liposomal Forms of Chlorin E6

Tararina,

Ageev,

Brodovskaya

et al. 2023

Pharm Chem J

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Evaluation of photocytotoxicity liposomal form of furanocoumarins Sosnowsky's hogweed

Cited by 8 publications

References 47 publications

Methoxyfuranocoumarins of Natural Origin–Updating Biological Activity Research and Searching for New Directions—A Review

Methoxyfuranocoumarins of Natural Origin–Updating Biological Activity Research and Searching for New Directions—A Review

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Comparative Study of the Photocytotoxicity of Two Liposomal Forms of Chlorin E6

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