Evaluation of photodynamic therapy in gastric cancer

Kato, Harubumi; Kawaguchi, Minoru; Konaka, Chimori; Nishimiya, Kensuke; Kawate, Norihiko; Yoneyama, Kazuo; Kinoshita, Komei; Noguchi, Masayuki; Ishii, Masanori; Shirai, Masahiro; Hirano, Takashi; Aizawa, Katsuo; Hayata, Yoshihiro

doi:10.1007/bf02030738

Cited by 34 publications

(17 citation statements)

References 9 publications

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“…The mechanism of cell kill is by chemotoxicity and there is less likelihood of viscus perforation (Barr et al, 1987b). PDT has been used to treat gastrointestinal tumours (Kato et al, 1986;Jin et al, 1987;Patrice et al, 1990;Krasner et al, 1990). Because of limited transmittance of light in tissue, it has been shown to be most effective in the treatment of small and early tumours (Kato et al, 1986;Jin et al, 1987;Krasner et al, 1990).…”

mentioning

confidence: 99%

“…PDT has been used to treat gastrointestinal tumours (Kato et al, 1986;Jin et al, 1987;Patrice et al, 1990;Krasner et al, 1990). Because of limited transmittance of light in tissue, it has been shown to be most effective in the treatment of small and early tumours (Kato et al, 1986;Jin et al, 1987;Krasner et al, 1990). Epithelial dysplasia is an early superficial form of neoplastic lesion which is confined only to the mucosa and PDT may be a useful treatment modality for this condition.…”

mentioning

confidence: 99%

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Photodynamic therapy of the normal rat stomach: a comparative study between di-sulphonated aluminium phthalocyanine and 5-aminolaevulinic acid

Loh

Bedwell²,

MacRobert³

et al. 1992

Br J Cancer

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confidence: 99%

mentioning

confidence: 99%

Photodynamic therapy of the normal rat stomach: a comparative study between di-sulphonated aluminium phthalocyanine and 5-aminolaevulinic acid

Loh

Bedwell²,

MacRobert³

et al. 1992

Br J Cancer

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“…These variables make it difficult to interpret the various data. Although numerous reports have shown that PDT can cause significant tumor destruction, 7,[91][92][93][94][95] there are few randomized trials or palliative protocols. Recently, there has been a trend in clinical PDT research to use PDT as an adjunct to curative surgery to aid in controlling locoregional recurrence.…”

Section: Approved Applicationsmentioning

confidence: 99%

“…92 This is a reasonable assumption because the gastric rugae and mucosal folds can shadow other areas from light. Gastric tumors may also spread over a large surface area, making light delivery even more difficult.…”

Section: Stomachmentioning

confidence: 99%

“…99,101,113,119,120 In addition to confirming the feasibility and safety of the procedure, these studies obtained mixed success in terms of tumor response: some report complete histologic response in "advanced" tumors, 121 whereas others report only partial response in "early" tumors. 92 Unfortunately, the analysis of PDT for gastric cancer is plagued by mixed and varied results with low patient numbers and inadequate follow-up.…”

Section: Stomachmentioning

confidence: 99%

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Current Concepts in Gastrointestinal Photodynamic Therapy

Webber¹,

Herman²,

Kessel³

et al. 1999

Annals of Surgery

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ObjectiveTo review current concepts of photodynamic therapy (PDT) applied to the treatment of tumors of the gastrointestinal tract. Summary Background DataPDT initially involves the uptake or production of a photosensitive compound by tumor cells. Subsequent activation of the photoreactive compound by a specific wavelength of light results in cell death, either directly or as a result of vascular compromise and/or apoptosis. MethodsThe authors selectively review current concepts relating to photosensitization, photoactivation, time of PDT application, tissue selectivity, sites of photodynamic action, PDT effects on normal tissue, limitations of PDT, toxicity of photosensitizers, application of principles of PDT to tumor detection, and current applications of PDT to tumors of the gastrointestinal tract. ResultsPDT is clearly effective for small cancers, but it is not yet clear in which cases such treatment is more effective than other currently acceptable approaches. The major side effect of PDT is cutaneous photosensitization. The major limitation of PDT is depth of tumor kill. As data from current and future clinical trials become available, a clearer perspective of where PDT fits in the treatment of cancers will be gained. Many issues regarding pharmacokinetic data of photosensitizers, newer technology involved in light sources, optimal treatment regimens that take advantage of the pharmacophysiology of photoablation, and light dosimetry still require solution. One can foresee application of differing sensitizers and light sources depending on the specific clinical situation. As technologic advances occur, interstitial PDT may have significant application.

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