Evaluation of physical, mechanical and biological properties of β-tri-calcium phosphate/Poly-3-hydroxybutyrate nano composite scaffold for bone tissue engineering application

Shahi, Shabnam; Karbasi, Saeed; Ahmadi, Tahmineh; Naeimi, Farid; Goodarzi, Vahabodin; Ebrahimi‐Barough, Somayeh

doi:10.1080/10667857.2020.1747806

Cited by 17 publications

(6 citation statements)

References 37 publications

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“…Shahi and co-authors [ 277 ] used the polymer replication method to prepare porous ceramic nanocomposite scaffolds consisting different weight fractions of nano β -tricalcium phosphate (nano- β -TCP) (with a particle size of around 50–70 nm) coated with PHB for 30 and 60 s. Results showed that the fabricated scaffold with 50 wt.% nano- β -TCP and a coating time of 30 s reflected desirable properties in bone tissue engineering. After examining the bioactivity of this scaffold, bone-like apatite layers were found to be well formed on the nanocomposite scaffold.…”

Section: Phas’ Modificationsmentioning

confidence: 99%

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Expanding Poly(lactic acid) (PLA) and Polyhydroxyalkanoates (PHAs) Applications: A Review on Modifications and Effects

et al. 2021

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The high price of petroleum, overconsumption of plastic products, recent climate change regulations, the lack of landfill spaces in addition to the ever-growing population are considered the driving forces for introducing sustainable biodegradable solutions for greener environment. Due to the harmful impact of petroleum waste plastics on human health, environment and ecosystems, societies have been moving towards the adoption of biodegradable natural based polymers whose conversion and consumption are environmentally friendly. Therefore, biodegradable biobased polymers such as poly(lactic acid) (PLA) and polyhydroxyalkanoates (PHAs) have gained a significant amount of attention in recent years. Nonetheless, some of the vital limitations to the broader use of these biopolymers are that they are less flexible and have less impact resistance when compared to petroleum-based plastics (e.g., polypropylene (PP), high-density polyethylene (HDPE) and polystyrene (PS)). Recent advances have shown that with appropriate modification methods—plasticizers and fillers, polymer blends and nanocomposites, such limitations of both polymers can be overcome. This work is meant to widen the applicability of both polymers by reviewing the available materials on these methods and their impacts with a focus on the mechanical properties. This literature investigation leads to the conclusion that both PLA and PHAs show strong candidacy in expanding their utilizations to potentially substitute petroleum-based plastics in various applications, including but not limited to, food, active packaging, surgical implants, dental, drug delivery, biomedical as well as antistatic and flame retardants applications.

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Section: Phas’ Modificationsmentioning

confidence: 99%

“…After examining the bioactivity of this scaffold, bone-like apatite layers were found to be well formed on the nanocomposite scaffold. This nanocomposite scaffold is believed to have a good potential for applications in bone tissue engineering [ 277 ].…”

Section: Phas’ Modificationsmentioning

confidence: 99%

Expanding Poly(lactic acid) (PLA) and Polyhydroxyalkanoates (PHAs) Applications: A Review on Modifications and Effects

et al. 2021

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“…For instance, Zhao et al [ 97 ] produced 3D porous HA structures with composite coatings based on PDLLA, either alone or in combination with calcium sulfate (CS) and chondroitin sulfate (ChS) powders, and they showed significant improvements in the mechanical properties of the structures. Similarly, Shahi et al [ 98 ] claimed that combining 50% of a β-TCP coating with PHB for 30 s showed desirable properties in bone tissue engineering, according to different morphological and mechanical tests. We encourage this issue to be considered when developing a construct, as it will be of great aid to maximize the characteristics of the composites.…”

Section: Most Relevant Polymeric Composites In Bone Regenerationmentioning

confidence: 99%

Applications of Polymeric Composites in Bone Tissue Engineering and Jawbone Regeneration

et al. 2021

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Polymer-based composites are a group of biomaterials that exert synergic and combined activity. There are multiple reported uses of these composites in multiple biomedical areas, such as drug carriers, in wound dressings, and, more prominently, in tissue engineering and regenerative medicine. Bone grafting is a promising field in the use of polymeric composites, as this is the second most frequently transplanted organ in the United States. Advances in novel biomaterials, such as polymeric composites, will undoubtedly be of great aid in bone tissue engineering and regeneration. In this paper, a general view of bone structure and polymeric composites will be given, discussing the potential role of these components in bone tissue. Moreover, the most relevant jawbone and maxillofacial applications of polymeric composites will be revised in this article, collecting the main knowledge about this topic and emphasizing the need of further clinical studies in humans.

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“…In addition, the reinforcement of tissue-engineered scaffolds with CNTs increases the wettability of the scaffolds [ 19 ]. The incorporation of β-TCP with a PCL scaffold increases the performance of the scaffold in terms of strength, hydrophilicity [206], and cell growth [ 20 , 21 ]. Further, the addition of β-TCP in the PLA scaffolds increases the degradation rate of 3D printed scaffolds and also osteo-conductivity, which is beneficial for the application of composite scaffolds in the field of tissue engineering [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

3D printed polycaprolactone/β-tricalcium phosphate/carbon nanotube composite – Physical properties and biocompatibility

Wang,

Liu,

Song

et al. 2024

Heliyon

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Evaluation of physical, mechanical and biological properties of β-tri-calcium phosphate/Poly-3-hydroxybutyrate nano composite scaffold for bone tissue engineering application

Cited by 17 publications

References 37 publications

Expanding Poly(lactic acid) (PLA) and Polyhydroxyalkanoates (PHAs) Applications: A Review on Modifications and Effects

Expanding Poly(lactic acid) (PLA) and Polyhydroxyalkanoates (PHAs) Applications: A Review on Modifications and Effects

Applications of Polymeric Composites in Bone Tissue Engineering and Jawbone Regeneration

3D printed polycaprolactone/β-tricalcium phosphate/carbon nanotube composite – Physical properties and biocompatibility

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