Evaluation of Phytochemical Screening and Antimicrobial Activities of Ethanolic Extracts of Leaves and Bark of Ardisia Colorata

Syed, Easin; Mashroor, Benyamin; Hossain, Fouad Md Delwar; Bi-Illah, Natik; Bhattacharjee, Rajib; Hannan, J. M. A.

doi:10.3329/ijpls.v2i4.17115

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…leaves give alkaloids, tannins, flavonoids, saponins, reducing sugar, steroid and terpinoids. 22 Leaves of Ardisia colorata is rich in bergenin and it can be used in diabetic complications as therapeutic medication. 23 Oral glucose induced hyperglycemia was evaluated by following the method of Puri et al with slight modification.…”

Section: Discussionmentioning

confidence: 99%

Effect of aqueous extract of Ardisia colorata Roxb. leaves on blood sugar in Albino rats

Ningthoujam,

Datta,

Zosangpuii

et al. 2024

Int J Res Med Sci

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Background: Diabetes is a group of common metabolic disorders that share the characteristic features of hyperglycemia. Ardisia colorata Roxb. leaf extract (AEAC) is reported to be used for the treatment of diabetes. So, the present study is undertaken to evaluate the effect of Ardisia colorata Roxb. leaves on blood sugar by using different hyperglycemic models in Albino rats. Methods: In both the glucose induced hyperglycemia model and streptozotocin induced hyperglycemia model, animals were divided into 4 groups of 6 animals each. 2% gum acacia were taken as control (group 1) and glimepiride 0.2 mg/kg were taken as standard (group 2). Hyperglycemic activity was checked at two different doses i.e., 200 mg/kg (test 1) and 400 mg/kg (test 2) of AEAC (given at group 3 and group 4 respectively) by assessing the decreased in blood sugar level using glucometer by following methods of these two models. The results were analyzed using one-way analysis of variance (ANOVA) followed by Bonferroni test. P value <0.05 was considered significant. Results: Test 2 showed significant reduction in blood sugar level when compared to control after 1 hour and 2 hours of drug administration in both the models whereas test 1 showed significant reduction only in glucose induced hyperglycemia model. There was significant difference when test 2 was compared to test 1 after 1 hour and 2 hours in both the models. Conclusions: The present studies showed that AEAC leaves produced significant reduction in blood sugar level. It might be suggested that flavonoids, alkaloids, tannins and terpenoids were responsible for the hypoglycemic activity of AEAC leaves.

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Section: Discussionmentioning

confidence: 99%

Effect of aqueous extract of Ardisia colorata Roxb. leaves on blood sugar in Albino rats

Ningthoujam,

Datta,

Zosangpuii

et al. 2024

Int J Res Med Sci

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“…Besides, A. compressa possesses significant hypoglycemic effects in Type 2 diabetic rats, and antioxidant activity and A. crispa showed in vitro cytotoxic activity and antioxidative actions against breast cancer cell lines [9]. Barks and leaves of A. colorata were extracted with ethanol having antimicrobial activities [10]. The present study protocol is designed to investigate phytochemical and pharmacological properties of A. solanacea leaves.…”

Section: Introductionmentioning

confidence: 99%

In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

et al. 2019

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Background: The Bangladeshi rural and hilly areas people have long tradition to use various medicinal plants for treating different diseases. That's why, the crude methanolic leaf extract of Ardisia solanacea with its different fractions (petroleum ether, carbon tetrachloride, n-hexane and chloroform fractions) were subjected to investigate bioactivities in swiss albino mice; namely analgesic, CNS, and Oral hypoglycemic activities, while in-vitro evaluation of cytotoxicity. Methods: Central nervous system activity was investigated by various method such as Elevated plus maze, Hole board, Hole cross and Open field test apparatus. Analgesic activity was evaluated by both acetic acid induced and tail immersion method. Hypoglycemic activity was evaluated by oral glucose tolerance test and cytotoxicity was evaluated by Brine shrimp lethality bioassay. Results: In CNS activity, among others fractions, ASCF fraction produced a significant anxiolytic activity in both elevated plus maze and Hole board test. During open-field test almost all the fractions of A. solanacea leaves extract display decreased locomotor activities that indicates significant sedative activity. The ASME and ASCF showed significant peripheral analgesic activity at a dose of 200 mg/kg and 400 mg/kg body weight (p < 0.05). In tail immersion method, among others extracts chloroform fractions exhibited significant (p < 0.05) elongation of reaction time 30 min after oral dose of 200 and 400 mg/kg body weight respectively. The methanolic and n-hexane extracts reduced blood glucose level significantly after 90 min with value of 53.94% and 48.15% respectively (p < 0.05). In case of cytotoxicity activity, among other fractions carbon tetrachloride fraction showed lowest LC 50 values. Conclusions: From the above results, it is clear that different fractions of A. solanacea showed significant pharmacological potentiality in different in-vitro and in-vivo study model. So, it will be very much possible source for an isolating lead compound for curing the numerous disorders.

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“…Friedelin was isolated for the first time from the genus of Ardisia 7 . Preliminary phytochemical screening of both the leaf and bark extract of Ardisia colorata revealed the presence of various classes of compounds such as saponins, reducing sugars, tannins, and terpenoids with minor presence of alkaloid and flavonoid 8 . The present investigation is aimed to screen out the phytochemicals from the leaf extract of Ardisia blatteri.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening of Ardisia Blatteri Gamble: An Endemic Plant of Southern Western Ghats, Tamil Nadu, India

Dhanasekaran¹,

Karuppusamy²,

Rajasekaran³

2016

Int. Res. J. Pharm.

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The genus Ardisia Sw (coralberry or marlberry). is the largest genus in the family Myrsinaceae and comprises approximately 500 species distributed throughout subtropical and tropical regions of the world. This genus is a good source of health promoting compounds and potent phytopharmaceuticals. In India, 13 species are enumerated. Within this, seven species are endemic to India and nine species are recorded in Tamil Nadu. Ardisia blatteri is an evergreen small tree, endemic to southern Western Ghats. The Preliminary phytochemical screening of plant revealed the presence of various classes of compounds such as alkaloids, flavonoids, saponins, reducing sugars, tannins, and terpenoids. GC-MS analysis has investigated on the ethanol extract of Ardisia blatteri, resulted with 40 known compounds in various degrees of distribution. Hexadecanoic acid (21.74%), Octamethyl (24.73%) are the major constituents. About 8 constituents are minor and 30 constituents are trace amount in the plant extract.

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Evaluation of Phytochemical Screening and Antimicrobial Activities of Ethanolic Extracts of Leaves and Bark of Ardisia Colorata

Cited by 3 publications

References 10 publications

Effect of aqueous extract of Ardisia colorata Roxb. leaves on blood sugar in Albino rats

Effect of aqueous extract of Ardisia colorata Roxb. leaves on blood sugar in Albino rats

In-vivo and in-vitro evaluation of pharmacological activities of Ardisia solanacea leaf extract

Phytochemical Screening of Ardisia Blatteri Gamble: An Endemic Plant of Southern Western Ghats, Tamil Nadu, India

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