Evaluation of phytoconstituents of <i>Tinospora cordifolia</i> against K417N and N501Y mutant spike glycoprotein and main protease of SARS-CoV-2- an in silico study

Choudhary, Princy; Singh, Tanu; Amod, Ayush; Singh, Sangeeta

doi:10.1080/07391102.2022.2062787

Cited by 3 publications

(1 citation statement)

References 63 publications

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“…In a drug screening experiment for five possible protein targets, namely, 3C-like protease (3CL pro ), papain-like protease (PL pro ), RNA replicase (RdRp), spike glycoprotein receptor-binding domain (SpG-RBD), and angiotensin-converting enzyme 2 (ACE2) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), investigators showed that obacunone might have potential activity against SARS-CoV-2, based on molecular docking and absorption, distribution, metabolism, excretion, and toxicity properties [67][68][69][70]. Oba-cunone could interact with the significant protease 3CL pro catalytic dimer, PL pro catalytic triad, and RdRp active site and bind to SARS-CoV-2 at the catalytic site of ACE2 and/or the RBD site [71].…”

Section: Potential Antiviral Activitymentioning

confidence: 99%

Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism

Zhou,

Gu,

et al. 2024

Molecules

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Obacunone, a natural triterpenoid, is an active component of the herbs Dictamnus dasycarpus Turcz. and Phellodendron amurense Rupr, and an indicator of the herbs’ quality. Owing to its multiple health benefits, several studies have investigated the multi-targeting potential action mechanisms of obacunone. To summarize recent developments on the pharmacological actions of obacunone and focus on the underlying molecular mechanisms and signaling networks, we searched PubMed, Europe PMC, Wiley Online Library, Web of Science, Google Scholar, Wanfang Medical Network, and China National Knowledge Infrastructure for articles published prior to March 2024. Existing research indicates obacunone has great potential to become a promising therapeutic option against tumors, fibrotic diseases, bone and cholesterol metabolism diseases, and infections of pathogenic microorganisms, among others. The paper contributes to providing up-to-date references for further research and clinical applications of obacunone.

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