Evaluation of PICC Complications in Orthopedic Inpatients with Bone Infection for Long-Term Intravenous Antibiotics Therapy

Schneider, Laura; Duron, Sandrine; Arnaud, François-Xavier; Bousquet, Aurore; Kervella, Yann; Bouzad, C.; Baccialone, J.; A’Teriitehau, C.; Potet, Julien

doi:10.5301/jva.5000389

Cited by 31 publications

(27 citation statements)

References 17 publications

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“…Across several studies, pain during catheter insertion was reported in 0% to 18% of patients using PICCs. [11][12][13][14][15] In the study by Konstantinou et al, 11 no significant difference was reported for pain during the procedure between PICCs and CICCs (7.7% vs. 12.2%, P = 0.502). In the study by Pedersen et al, 14 8.7% of patients with PICCs experienced pain during insertion, compared to 23.4% of patients with PIVC lines.…”

Section: Efficacy Outcomesmentioning

confidence: 90%

“…The rates of removal due to complications were 3.5% to 48% with PICCs [4][5][6]12,14,15,20,[23][24][25][26][27]29,32,33,35,37,38,45,46 compared to 67% to 81.2% with PIVCs 6,14 and 26% to 78% with CICCs. 5,6,33 In the study by Cotogni et al 5 in which catheters were used for home parenteral nutrition in patients with cancer, the ratio of complications leading to removal over total complications was significantly lower for PICCs versus CICCs (55% vs. 85%, P < 0.05).…”

Section: Safety Outcomesmentioning

confidence: 94%

“…The percentage of patients experiencing placement complications with PICCs ranged from 0 to 7.4%. 4,12,15,21,30,31,[35][36][37][38][39][40][41][42][43][44] Placement complications were not reported for comparators (CICCs and PIVCs).…”

Section: Efficacy Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Short- and Intermediate-Term Use of Peripherally Inserted Central Catheters in Europe: A Systematic Literature Review

Mussa

Alsbrooks

Hutcheson³

2019

Journal of the Association for Vascular Access

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Section: Efficacy Outcomesmentioning

confidence: 90%

Section: Safety Outcomesmentioning

confidence: 94%

See 1 more Smart Citation

Short- and Intermediate-Term Use of Peripherally Inserted Central Catheters in Europe: A Systematic Literature Review

Mussa

Alsbrooks

Hutcheson³

2019

Journal of the Association for Vascular Access

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“…However, intravenous therapy carries substantial risks, and it is inconvenient for patients [2]. In particular, long-term intravenous antibiotic therapy may cause complications such as catheter-related bloodstream infections and thrombosis [3]. Currently, the mainstay treatment method is debridement followed by systemic antibiotic therapy, which commonly includes intravenous infusion for 2 weeks followed by oral antibiotics for 4-6 weeks [4,5].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases

Wang

Fang

Chen

et al. 2020

BMC Musculoskelet Disord

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Background: Our aim was to investigate the clinical efficacy and complications of antibiotic treatment regimens for patients with bone infection. Methods: We retrospectively analysed patients with bone infection admitted to our hospital between March 2013 and October 2018. After surgical debridement was performed, the patients were divided into three groups: IV group (intravenous antibiotics for 2 weeks); oral group (intravenous antibiotics for 2 weeks followed by oral antibiotics for 4 weeks); and rifampicin group (intravenous antibiotics for 2 weeks followed by oral antibiotics plus rifampicin for 4 weeks). The infection control rate and complications were compared among the three groups. Results: A total of 902 patients were enrolled. The infection sites included 509 tibias, 228 femurs, 32 humeri, 23 radii and ulnae, 40 calcanei, and 47 miscellaneous sites, as well as 23 multiple-site infections. After at least 6 months of follow-up, 148 (16.4%) patients had an infection recurrence. The recurrence rate of the IV group was 17.9%, which was not significantly higher than the recurrence rates of the oral group (10.1%) and rifampicin group (10.5%), P = 0.051. The incidence of abnormal alanine aminotransferase (ALT) levels in the IV group was 15.1%, which was lower than that in the oral group (18.0%) and rifampicin group (27.4%), P = 0.026. The rates of proteinuria in the three groups were 3.2, 4.5, and 9.3%, respectively, P = 0.020. Conclusions: After debridement of bone infection, short-term antibiotic treatment regimens might offer similar rates of infection eradication while avoiding the risk of renal and hepatic damage associated with prolonged antibiotic use. The level of clinical relevance: Stage III.

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“…However, intravenous therapy carries with it substantial risks and it is inconvenient for patients [2]. In particular, long-term intravenous antibiotics therapy may bring the complication of catheter-related bloodstream infections and thrombosis [3]. Currently, the mainstream treatment method is debridement followed by systemic antibiotics therapy, which is commonly intravenous infusion for two weeks followed by oral antibiotics for 4-6 weeks [4,5].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases

Wang

Chen

et al. 2020

Preprint

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Purpose: Our aim was to investigate the clinical efficacy and complications of antibiotics treatment duration for the patients of bone infection. Methods: We retrospectively analyzed the patients with bone infection admitted to our hospital between March 2013 and October 2018. The surgical debridement was performed and the patients were divided into three groups: IV group (Intravenous antibiotics for 2 weeks); Oral group (Intravenous antibiotics for 2 weeks followed by oral antibiotics for 4 weeks); Rifampicin group (Intravenous antibiotics for 2 weeks followed by oral antibiotics plus rifampicin for 4 weeks). The infection control rate and complications were compared. Results ： A total of 902 patients were enrolled, the infection sites included 509 tibias, 228 femurs, 32 humeri, 23 radii and ulnae, 40 calcanei, 23 multiple-site infections and the other sites 47 cases. After at least 6 months of follow-up, 148 (16.4%) patients had recurrence of infection. The recurrence rate of IV group was 17.9%, which was no significant higher than that of Oral group (10.1%) or Rifampicin group (10.5%). The abnormal rate of Glutamic-pyruvic transaminase(ALT) in IV group was 15.1%, which was lower than that of Oral group (18.0%) and Rifampicin group (27.4%), P=0.026. The positive rates of proteinuria in the three groups were 3.2%, 4.5%, and 9.3%, respectively, P=0.020. Conclusion: After debridement of bone infection, the additional oral antibiotic treatment may increase the damage of liver and kidney, and can not significantly reduce the infection recurrence rate. Therefore, it is recommended to adopt short-term systemic antibiotic treatment after debridement.

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Evaluation of PICC Complications in Orthopedic Inpatients with Bone Infection for Long-Term Intravenous Antibiotics Therapy

Abstract: Even in orthopedic patients with chronic orthopedic bone infection, PICCs have a low rate of complication. The increasing lumen number of the PICC is a potential risk factor in our series.

Cited by 31 publications

References 17 publications

Short- and Intermediate-Term Use of Peripherally Inserted Central Catheters in Europe: A Systematic Literature Review

Short- and Intermediate-Term Use of Peripherally Inserted Central Catheters in Europe: A Systematic Literature Review

Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases

Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases

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