Evaluation of Pill Counts Adherence with Self-Reported Adherence in Assessing Antiretroviral Therapy Behavior of Women living with HIV at a Faith-based Clinic in Malawi

McKinney, Ogbochi; Pearce, Daniel; Banta, Jim E.; Mataya, Ronald; Muula, Adamson S; Crounse, James; Mukaire, Pamela; Matipwiri, Pax A

doi:10.4172/2572-0805.1000120

Cited by 4 publications

(2 citation statements)

References 27 publications

(51 reference statements)

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“…During the session, research staff counted the number of pills remaining and recorded the medication names, refill date, quantity dispensed, and prescribed frequency and dosage. Percent adherence was calculated as: (( quantity dispensed–remaining )/( quantity prescribed per day*days since last refill ))*100 (McKinney et al, 2016; Mudhune et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Delay discounting and adjuvant endocrine therapy adherence in hormone receptor-positive breast cancer.

Vaughn¹,

Ammermann²,

Lustberg³

et al. 2021

Health Psychology

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Objectives: Oral endocrine therapy improves survival among hormone responsive breast cancer (HRBC) survivors; however, 30-70% of patients are nonadherent. One patient-centered factor that may impact adherence is delay discounting (DD), or the degree to which patients value future outcomes. In prior research, DD is robustly associated with maladaptive health behavior; but no work to our knowledge has examined delay discounting and medication nonadherence in breast cancer patients. Study 1 examined cross-sectional associations between DD and endocrine therapy nonadherence. Study 2 examined whether DD in the HRBC population is amenable to a brief intervention-episodic future thinking (EFT), in which participants preexperience future events. Method: In Study 1, HRBC survivors completed assessments of DD and endocrine therapy adherence (pill count and self-report). In Study 2, participants were randomized to engage in a brief behavioral intervention (EFT) or a control condition, and again completed assessments of DD. Results: Eighty nine female HRBC survivors completed Studies 1 and 2. Controlling for other known risk factors, greater DD was significantly associated with poorer pill-count but not self-report adherence. In Study 2, the EFT intervention significantly reduced DD when compared to control episodic thinking. Conclusions: DD is associated with direct-observation (pill count) measures of endocrine therapy adherence in HRBC survivors, suggesting it is a potential therapeutic target for improving adherence. This target is also amenable to intervention with EFT.

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Section: Methodsmentioning

confidence: 99%

Delay discounting and adjuvant endocrine therapy adherence in hormone receptor-positive breast cancer.

Vaughn¹,

Ammermann²,

Lustberg³

et al. 2021

Health Psychology

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show abstract

“…The methods mostly used in the sub‐Saharan African setting – namely, pill counts, electronic monitoring systems, Adults Aids Clinical Trial Group adherence questionnaire, plasma drug levels and patient self‐report – all have strengths and weaknesses [ 10 , 11 , 12 ]. Bringing back the dispensed pharmaceutical packaged antiretroviral pill bottle (pillbox) on the next visit in order to count pills is requested in many care and treatment centres in sub‐Saharan Africa [ 13 , 14 ] and is also recommended by the WHO [ 15 ]. However, carrying the pillbox is often associated with fear of being identified as HIV‐positive [ 16 ], with stigma being one of the major factors leading to poor adherence and disclosure [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Failure to return pillbox is a predictor of being lost to follow‐up among people living with HIV on antiretroviral therapy in rural Tanzania

et al. 2021

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Objectives Pill count is used to assess drug adherence in people living with HIV (PLHIV). Carrying a pillbox is associated with fear of concealment and stigma and might indicate poor adherence and predict someone who will be lost to follow‐up (LTFU). We therefore assessed the association between pillbox return and being LTFU in rural Tanzania. Methods This is a nested study of the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO). We included PLHIV aged ≥ 18 years enrolled in KIULARCO between January 2013 and March 2019 with follow‐up through January 2020, who were on antiretroviral treatment (ART) for ≥ 6 months. Baseline was defined as the latest ART initiation or KIULARCO enrolment. We determined the association between time‐dependent failed pillbox return updated at every visit and LTFU using Kaplan–Meier estimation and Cox models. Results Among 2552 PLHIV included in the study, 1735 (68.0%) were female, 959 (40.3%) had a WHO stage III/IV and 1487 (66.4%) had a CD4 cell count < 350 cells/µL. The median age was 38.4 years [interquartile range (IQR): 31.7–46.2]. During a median follow‐up of 33.1 months (IQR: 17.5–52.4), 909 (35.6%) participants were LTFU, 43 (1.7%) died and 194 (7.6%) had transferred to another clinic. The probability of being LTFU was higher among PLHIV with failed pillbox return than among those who returned their pillbox [30.0%, 95% confidence interval (CI): 26.8–33.2% vs. 19.4%, 95% CI: 17.4–21.6%, respectively, at 24 months (hazard ratio = 1.67, 95% CI: 1.46–1.90; p < 0.001)]. Conclusions Failed pillbox return was associated with a higher risk of being LTFU and could be used as a simple tool to identify PLHIV for appropriate interventions to reduce their chance of being LTFU.

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Application of the theory of planned behaviour to HIV management and prevention in sub-Saharan Africa: a systematic review

Tarkang

Adu-Gyamfi

Sackey

et al. 2023

International Journal of Health Promotion and Education

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Evaluation of Pill Counts Adherence with Self-Reported Adherence in Assessing Antiretroviral Therapy Behavior of Women living with HIV at a Faith-based Clinic in Malawi

Abstract: Background: Antiretroviral treatment is imperative for increasing survival among HIV positive individuals. Treatment success is assured by strict adherence to antiretroviral therapy (ART) resulting in improved quality and quantity of life.

Cited by 4 publications

References 27 publications

Delay discounting and adjuvant endocrine therapy adherence in hormone receptor-positive breast cancer.

Delay discounting and adjuvant endocrine therapy adherence in hormone receptor-positive breast cancer.

Failure to return pillbox is a predictor of being lost to follow‐up among people living with HIV on antiretroviral therapy in rural Tanzania

Application of the theory of planned behaviour to HIV management and prevention in sub-Saharan Africa: a systematic review

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