Evaluation of Plasma Assisted Noninvasive Surgery (PANIS) As a New Approach for the Treatment of Conjunctival Concretions: A Clinical Case Series

Abstract

Background and Objective: Plasma is one of the newest therapies recently used. This study aimed to evaluate a quick treatment modality of conjunctival concretions using plasma as a noninvasive procedure. Methods: Six eyes of six patients with conjunctival concretions were evaluated. The procedure was performed using plasma spots generated by the white handpiece of the Plexr device. The eyelid was everted and concretions sublimated by plasma spots from the upper and lower eyelids. Refractive Errors, visual acuity (BCVA and UCVA), Ocular Surface Disease Index (OSDI), and Intraocular pressure (IOP) were measured before and after six months of the procedure. Results: The results of 6 months follow-up show that this effective method had no recurrence or side effects. Treatment was effective in all of the patients. No complication and recurrence was observed. The OSDI score was improved to the normal range. This method had no effects on Refractive Errors, Visual Acuity, and IOP. Conclusion: Based on the results, it seems that the PANIS method can be used as a practical, quick, and straightforward approach for the treatment of conjunctival concretions.

Evaluation of the Effect of Plasma Occlusion of Punctum (POP) on Dry Eye Disease Treatment: A 6-month Randomized Clinical Trial

“…In another research, Inflammatory cytokines in tear and serum has checked 4 times within 6 months follow-up after plasma spots on Rats conjunctiva, and this study also reported no persistent inflammatory responses [29]. After 3 animal studies, human ocular surface diseases have been targeted to treating with atmospheric low-temperature plasma and published case series studies, including conjunctivochalasis, conjunctival cyst, pinguecula, pterygium, punctal occlusion, conjunctival concretion, pseudophakic bullous keratopathy, conjunctival nevus [15,[30][31][32][33][34]. All these novel modalities have been taught to ophthalmologists all over the world, as a safe, office-based and effective approaches [35].…”

Innovative Solutions for Swift Enhancement: A Case Series on Filamentary keratitis treatment with Plasma Occlusion of Puncta

“…These safety evaluations confirmed the initiation of human trials to use plasma technology for treating ocular surface diseases such as conjunctival cyst, conjunctivochalasis, pinguecula, pseudophakic bullous keratopathy, conjunctival concretion, pterygium, dry eye disease, and conjunctival nevus. A published case series about the PANIS modality (plasma-assisted noninvasive surgery) with an average follow-up of 6 months proved the safety and efficacy of this novel technique for treating common ocular surface diseases [7,[25][26][27][28][29][30][31][32].…”

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

“…The PANIS method has been used to treat ocular surface diseases such as conjunctivochalasis, conjunctival cysts, dry eye disease, pinguecula, conjunctival concretion, pseudophakic bullous keratopathy, pterygium, and conjunctival nevus [36][37][38][39][40][41][42][43][44][45][46].…”