Evaluation of Plasma D-Dimer Concentration Among Normal and Complicated Pregnancies, Saudi Arabia

Abstract

Objectives: The purpose of the current work is to evaluate D-dimer plasma level among both normal and complicated pregnancies such as gestational diabetes (GD) and hypertension (GH) among Saudi females. It is also focused on exhibiting any possible factors that could also play a role in rising D-dimer levels besides the age of the pregnant woman and the period of gestation. Materials and Methods: A semi-quantitative latex agglutination assay was performed in the blood sample of healthy non-pregnant, pregnant and pregnant females with GD and GH. Results: The results exhibited that 92% of pregnancies with GH and 90% of multiple pregnancies had high D-dimer levels. The analysis of the effect of age of pregnant women on D-dimer concentrations presented that 100% of pregnant women with GD, GH or multiple pregnancies aged above 40, had high levels of D-dimer. The results of the relationship between gestational age of pregnancies and D-dimer showed that by reaching the third trimester, about 66.6% of women who had multiple pregnancies had D-dimer concentration above 2000 ng/mL. Interestingly, all the pregnant females with GH had D-dimer concentrations above 2000 ng/mL. Conclusions: This study postulated that the concentrations of D-dimer significantly increase during pregnancy associated with common complications such as GD and GH. It is the first study to demonstrate the possible risk factors during pregnancy, which include age, number of pregnancies, gestational age and pregnancies with GD and GH, especially among Saudi Arabian women.

Assessment of D-Dimer Levels in Southwestern Nigerian Pregnant Women

“…It was observed that a high proportion (41.6%) of the subjects had increased D-dimer with the remaining 58.3% having normal concentration; over 30% and 20% had decreased PT and INR respectively and minute proportion having increased concentrations while those with decreased and increased APTT are 13 and 4.6% respectively. [7][8][9][10] and illustrated the concentration of D-dimer amplified during gestation compared to non-gestation state with a gradual increase across the parturient period [11,7].…”

Comparison of the D-dimer concentration in pregnant women with or without pulmonary thromboembolism

“…D-dimer is a minor protein product, which is found in circulation in negligible amounts because of endogenous fibrinolysis. [ 11 ] Many studies have examined the level of D-dimer during pregnancy[ 10 11 12 ] and showed that D-dimer values were higher during pregnancy compared to nonpregnancy. In addition, increased levels of D-dimer were observed in the third trimester of normal pregnancy.…”