Evaluation of Plasma Vitamin A and E Levels and Tear Film Changes in Patients with Psoriasis Vulgaris

Demir, Helin Deniz; Aydın, Erdinç; Sezer, Engin; Yardım, Hüseyin

doi:10.3341/kjo.2013.27.3.158

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…According to previous study and following formula, sample size was 31 persons in each study groups when the significant level and power were respectively 0.05 and 0.85 to determine TBUT difference between study groups. 15 n n z z s s…”

Section: Discussionmentioning

confidence: 99%

The study of dry eye and meibomian glands in psoriasis

Taheri

Allahyari

Zeinaly

et al. 2021

European Journal of Ophthalmology

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Background: To investigate aqueous and lipid layers of the tear film as well as meibomian gland structure by meibography in psoriatic patients in the Iranian population. Methods: This case-control study was conducted on 31 psoriasis patients and 31 controls in Birjand University of Medical Sciences in 2018. The sampling method was available from the date of approval of the proposal in the Ethics Committee until it reached the sample size. After entering the study, patients were examined individually with a slit lamp. Then, Ocular Surface Disease Index (OSDI) score assessment, Schirmer test 1, lacrimal measurement with SM tube, tear break-up time (TBUT), and meibomian glands imaging by SBM Sistemi were done. Finally, the obtained data were entered into SPSS 15 software and analyzed at a significant level of less than 0.05. Results: The two groups were matched according to age and gender ( p = 0.39 and p = 0.80; respectively). With the exception of the SM Tube score, the mean of all tear film and meibomian glands functional and structural parameters including Schirmer test 1, TBUT, and meibography were significantly different between patients and control groups. Moreover, the proportion of abnormal OSDI (OSDI ⩾ 13) and the dry eye was significantly higher in psoriasis patients. Conclusions: Psoriasis is associated with dry eye as well as meibomian glands atrophy and dysfunction.

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Section: Discussionmentioning

confidence: 99%

The study of dry eye and meibomian glands in psoriasis

Taheri

Allahyari

Zeinaly

et al. 2021

European Journal of Ophthalmology

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“…A score of 12 is typically used as a cutoff for normal, 13-22 for mild dry eye, 23-32 for moderate dry eye, and ≥ 33 for severe dry eye. [13][14][15] The total OSDI score was measured as total OSDI score × 25/ total number of questions answered. 13,14 The TBUT and Schirmer-1 test were evaluated after a full ophthalmologic examination.…”

Section: Introductionmentioning

confidence: 99%

The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye

Kurtul

Ozer

Aydinli

2015

Eye

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Purpose To investigate the effect of vitamin D deficiency on tear break-up time (TBUT) and Schirmer test scores and to assess their relationship in non-Sjögren dry-eye patients. Methods Thirty-four patients with serum vitamin D deficiency and 21 control subjects with normal vitamin D levels were included in this study. The TBUT and Schirmer-1 test without topical anesthesia were performed to all patients. Results The mean TBUT were 5.18 ± 2.15 and 7.36 ± 3.10 s and Schirmer scores were 12.18 ± 6.44 and 18.57 ± 8.99 mm in the study and control groups, respectively. TBUT scores and Schirmer-1 results of the study group were significantly lower than the control group (P = 0.01 and 0.007, respectively). The mean vitamin D levels were 11.50 ± 1.8 ng/ml in the study group and 32.8 ± 8.72 ng/ml in control group (P = 0.001). Dry-eye symptoms were detected in all patients in the study group and 15% of the patients in the control group. Conclusions We demonstrated that vitamin D deficiency decreases the TBUT and Schirmer test values and may be associated with dry-eye symptoms in non-Sjögren syndrome.

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“…The important immunoregulatory functions of the fat-soluble vitamins (vitamins A, D and E) and their role in the regulation of autoimmune diseases have been shown. 15,16 Especially the vitamin-D deficiency occurs at a higher rate in patients with autoimmune disorders. 15,[17][18][19] The effect of environmental and hormonal factors, such as vitamin D were mentioned in the pathogenic process of dry eye disease.…”

Section: Resultsmentioning

confidence: 99%

“…15,16 Especially the vitamin-D deficiency occurs at a higher rate in patients with autoimmune disorders. 15,[17][18][19] The effect of environmental and hormonal factors, such as vitamin D were mentioned in the pathogenic process of dry eye disease. 4,6 It is now accepted that dry eye is a localized autoimmune disease and irregular protective immunoregulation and proinflammatory pathways of the ocular surface cause this disorder.…”

Section: Resultsmentioning

confidence: 99%