Evaluation of platelet indices as diagnostic biomarkers for colorectal cancer

Abstract

Altered platelet indices, including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), have been found in various cancer types. This study aimed to evaluate the role of platelet indices as potential biomarkers for the diagnosis of colorectal cancer (CRC), and to assess the association between platelet indices and CRC clinicopathological characteristics. The study included 783 subjects with CRC, 463 subjects with colorectal adenomas (CA), and 689 control subjects from June 2015 to October 2017. All participants’ clinicopathological characteristics were collected and analyzed. Here, we found that PC, MPV and PCT levels in CRC patients were significantly higher than those in CA patients and healthy participants (p < 0.001); however, PDW level in CRC patients was significantly higher than that in healthy participants while lower than that in CA patients. Receiver-operating characteristic (ROC) analysis indicated that combined detection of PCT and CEA appears to be a more effective marker to distinguish CRC patients from CA patients, with 70% sensitivity and 83% specificity. Among CRC patients, PC and PCT levels were associated with TNM stages and tumor size; MPV and PCT levels were associated with vascular invasion. Our findings suggest that altered PC, MPV and PCT levels might serve as potential biomarkers for the diagnosis and prognosis of CRC.

The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal

“…Among three studies that analysed benign polyps, on average, those with a diagnosis had 40.16 (SD = 27.16) 10 9 /L higher platelet count than those with benign polyps at zero to six months before diagnosis. Zhu 2018 [63] derived an optimal cut-off of 242.5 10 9 /L in a Chinese population to distinguish cases with those with benign polyps, with 62% sensitivity and 72% specificity (c-statistic = 0.71, 95% CI = 0.68-0.74). Zhu 2018 [63] derived an optimal cut-off of 242.5 10 9 /L in a Chinese population to distinguish cases with those with benign polyps, with 62% sensitivity and 72% specificity (c-statistic = 0.71, 95% CI = 0.68-0.74).…”

“…Where the SE of the mean difference was derived using the nearest p-value approach (Goshen 2017 [28] and Zhu 2018 [63]), we are aware that this may over-estimate the SE and could influence the weight of the study on the overall, pooled estimate in the meta-analysis. Readers should consider this when reading these results.…”

<p>Mean Platelet Volume Has Prognostic Value in Chronic Lymphocytic Leukemia</p>

“…In colorectal carcinoma the MPV level was significantly higher than in patients with colorectal adenoma or healthy participants; moreover, MPV was significantly higher in patients with metastases compared to those with no metastasis. 4,24 In gastric cancer, a higher baseline MPV level was correlated with a greater number of metastases and worse response to chemotherapy. 25 A similar correlation was described in breast cancer or pancreatic cancer.…”

Preoperative Anemia and Thrombocytosis Predict Adverse Prognosis in Non-Metastatic Renal Cell Carcinoma With Tumor Thrombus

“…Thrombocytosis had been found as a worse prognostic predictor in different kind of cancer, include nasopharyngeal carcinoma [20], gynecologic malignancies [21], melanoma [22] and colorectal cancer [23].In RCC, thrombocytosis also could be regard as a prognostic indicator. Several study had already shown patients with preoperative thrombocytosis had a worse survival than those who without [24][25][26].Although none of these study had con rmed the thrombocytosis had worse prognosis in population of RCC with TT, previous study had found that bland thrombus in RCC with TT was associated with adverse survival [27].…”