Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug

Ma, Minglu; Cheng, Yiyun; Xu, Zhenhua; Xu, Peng; Qu, Haiou; Fang, Yujie; Xu, Tongwen; Wen, Longping

doi:10.1016/j.ejmech.2006.07.015

Cited by 178 publications

(78 citation statements)

References 30 publications

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“…Staphylococcus aureus, Bacillus anthracis [70] Dendrimers PAMAM Silver salts Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli [71] Sulfamethoxazole Escherichia coli [72] Nadifloxacin and Prulifloxacin Escherichia coli [41] Azithromycin Chlamydia trachomatis [73] PLCP Artemether Plasmodium falciparum [74] Reproduced from [39] macromolecules such as proteins, antibiotics and oligosaccharides [30][31][32]. Covalent modification by the organic functionalization of end groups and side walls of f-CNTs allows for a dramatic increase of the solubility of functionalized carbon nano-tubes in a range of solvents, including water [33].…”

Section: Carbon Nano-tubesmentioning

confidence: 99%

Nano-technology for targeted drug delivery to combat antibiotic resistance

Sharma

Arya

Dua

et al. 2012

Expert Opinion on Drug Delivery

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Section: Carbon Nano-tubesmentioning

confidence: 99%

Nano-technology for targeted drug delivery to combat antibiotic resistance

Sharma

Arya

Dua

et al. 2012

Expert Opinion on Drug Delivery

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“…[8][9][10][11][12] These applications include drug delivery, gene delivery, enzyme and protein immobilization, magnetic resonance imaging (MRI), dendrimer-protein conjugates, dendrimer-peptide conjugates, etc. 5,6,8,11,[13][14][15] These unique nonlinear polymers have many functional end groups that can be converted to other groups by functional group inversion (FGI) method.…”

Section: -7mentioning

confidence: 99%

Covalent Immobilization of Trypsin on a Novel Aldehyde-Terminated PAMAM Dendrimer

Hamidi¹,

Rashidi²,

Asgari³

et al. 2012

Bulletin of the Korean Chemical Society

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Dendrimers are a novel class of nonlinear polymers and due to their extensive applications in different fields, called versatile polymers. Polyamidoamine (PAMAM) dendrimers are one of the most important dendrimers that have many applications in nanobiotechnology and industry. Generally aldehyde terminated dendrimers are prepared by activation of amine terminated dendrimers by glutaraldehyde which has two problems, toxicity and possibility of crosslink formation. In this study, novel aldehyde-terminated PAMAM dendrimer was prepared and used for covalent immobilization of trypsin by the aim of finding a special reagent which can prevent crosslinking and deactivation of the enzyme. For this purpose aminoacetaldehydedimethylacetal (AADA) was used as spacer group between aldehyde-terminated PAMAM and trypsin.The findings of this study showed that immobilization of trypsin not only resulted higher optimal temperature, but also increased the thermal stability of the immobilized enzyme in comparison to the free enzyme.

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“…1 These monodispersed dendritic molecules have a strictly defined shape and size and are able to encapsulate drug molecules, resulting in formation of host-guest complexes. [2][3][4][5][6][7][8][9][10] On the other hand, full-generation PAMAM dendrimers have surface amine groups (32 amine groups in the third-generation PAMAM dendrimer, G3), offering an easy route for formation of conjugates with drugs. [11][12][13][14][15][16][17][18][19][20][21] Due to the relatively low toxicity of PAMAM dendrimers, [22][23][24][25] they are frequently used as transdermal diffusion promoters.…”

Section: Introductionmentioning

confidence: 99%

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate

Filipowicz¹,

Wołowiec²

2012

IJN

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Background: Bioconjugates of a polyamidoamine (PAMAM) G3 dendrimer and an aldehyde were synthesized as carriers for vitamins A and B 6 , and the bioavailability of these vitamins for skin nutrition was investigated. Methods: Nuclear magnetic resonance (NMR) and ultraviolet-visible methods were used to characterize the structure of the bioconjugates and for monitoring release of pyridoxal (Pyr) and pyridoxal phosphate (PLP) from these bioconjugates in vitro. A skin model permeation of bioconjugates was also studied in a Franz chamber. Results: A transdermal G3 PAMAM dendrimer was used to synthesize bioconjugates with trans-retinal (Ret), pyridoxal (Pyr), or PLP. These nanomolecules, containing up to four covalently linked Ret, Pyr, or PLP (G3 4Ret , G3 4Pyr , and G3 4PLP ), were able to permeate the skin, as demonstrated in vitro using a model skin membrane. PLP and Pyr bound to a macromolecular vehicle were active cofactors for glutamic pyruvic transaminase, as shown by 1 H NMR spectral monitoring of the progress of the L-alanine + α-ketoglutarate → glutamic acid + pyruvic acid reaction. Conclusion: PAMAM-PLP, PAMAM-Pyr, and PAMAM-Ret bioconjugates are able to permeate the skin. PLP and Pyr are available as cofactors for glutamic pyruvic transaminase.

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Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug

Cited by 178 publications

References 30 publications

Nano-technology for targeted drug delivery to combat antibiotic resistance

Nano-technology for targeted drug delivery to combat antibiotic resistance

Covalent Immobilization of Trypsin on a Novel Aldehyde-Terminated PAMAM Dendrimer

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate

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