2015
DOI: 10.1089/ten.tea.2014.0366
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Evaluation of Polycaprolactone Scaffold with Basic Fibroblast Growth Factor and Fibroblasts in an Athymic Rat Model for Anterior Cruciate Ligament Reconstruction

Abstract: Anterior cruciate ligament (ACL) rupture is a common ligamentous injury often necessitating surgery. Current surgical treatment options include ligament reconstruction with autograft or allograft, which have their inherent limitations. Thus, there is interest in a tissue-engineered substitute for use in ACL regeneration. However, there have been relatively few in vivo studies to date. In this study, an athymic rat model of ACL reconstruction was used to evaluate electrospun polycaprolactone (PCL) grafts, with … Show more

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Cited by 45 publications
(30 citation statements)
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“…By rolling rectangular sections of the electrospun nanofiber sheets to create nanofiber bundles it creates a robust structure which supports cell growth and proliferation, cell elongation, and has material properties that are comparable to the properties of the native human ACL [16][17][18] . Other have attempted to use stacked PCL sheets for ACL replacement and while transient immune responses were noted 15 , they subsided and the potential for heparin mediated growth factor release was noted, as a technique for further encouraging de novo extracellular matrix deposition 35,36 . Similarly, Bosworth et al reported that tightly wound PCL yarn could be utilized as a substrate for tendon fibroblast adhesion and proliferation 37 .…”
Section: Discussionmentioning
confidence: 99%
“…By rolling rectangular sections of the electrospun nanofiber sheets to create nanofiber bundles it creates a robust structure which supports cell growth and proliferation, cell elongation, and has material properties that are comparable to the properties of the native human ACL [16][17][18] . Other have attempted to use stacked PCL sheets for ACL replacement and while transient immune responses were noted 15 , they subsided and the potential for heparin mediated growth factor release was noted, as a technique for further encouraging de novo extracellular matrix deposition 35,36 . Similarly, Bosworth et al reported that tightly wound PCL yarn could be utilized as a substrate for tendon fibroblast adhesion and proliferation 37 .…”
Section: Discussionmentioning
confidence: 99%
“…Although, PCL displays appropriate biocompatibility and tissue integration, it lacks bioactivity, hence the incorporation of biological cues are necessary to initiate the regenerative process subsequent to implantation. This can be achieved through incorporation of growth factors into an electrospun mesh and by combining the scaffold with cells which is the strategy utilized in the present study. The concept of cell sheet technology has been pioneered and extensively utilized for tissue engineering and regenerative medicine by the prominent group of Prof. Okano .…”
Section: Discussionmentioning
confidence: 99%
“…Col has been widely combined with various polymers, often as a coating to stimulate tendon/ligament regeneration [80,81,92,107]. Similarly to the previously reported work of Yang et al [106], Xu et al [107] studied three morphologies (random nanofiber, aligned nanofibers and aligned nanoyarn) of electrospun scaffolds composed by PLCL and in this case, collagen type I, for tendon tissue engineering.…”
Section: Composites Blends and Hybrid Materials Based On Natural Andmentioning
confidence: 97%
“…Concerning PCL, it is a hydrophobic polyester with semi-crystalline structure, containing caprolactone subunits [39]. It exhibits favorable biocompatibility, adequate mechanical strength, high elasticity as well as long degradation time which has prompted its application in tissue engineering [80]. Comparing to PLLA, PCL presents a slower degradation rate.…”
Section: Advantages Disadvantagesmentioning
confidence: 99%
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