Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

Satturwar, P. M.; Fulzele, S. V.; Dorle, A. K.

doi:10.1208/pt060481

Cited by 39 publications

(23 citation statements)

References 28 publications

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“…About 1 g of fused calcium chloride was taken in the vials and the polymer films were fixed over the brim with the help of adhesive tape. Then the vials were weighed and stored in a humidity chamber of 70 -80 % RH condition for a period of 24 h. The vials were removed and weighed after 24 h to note down the weight gain and transmission rate was found out 13 .…”

Section: Water Vapor Transmission Ratementioning

confidence: 99%

Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

John¹,

Kumar²,

Samuel³

2013

Int. Res. J. Pharm.

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The aim of our study was to design and evaluate Amlodipine transdermal patches using polymers such as ethyl cellulose. Matrix type transdermal patches containing Amlodipine were prepared by solvent casting method by using polymers like ethylcellulose 1 %, 1.5 %, 2 % and 2.5 % and a total of eight formulations were prepared. Plasticizers used were propylene glycol and dibutylpthalate. The transdermal patches were evaluated for their physicochemical properties like folding endurance, thickness, percentage moisture loss, percentage moisture absorption, drug content and water vapour transmission rate. The diffusion studies were performed by using franz diffusion cell. Formulation E6 (1.5 % Ethylcellulose with dibutylphthlate) as plasticizers showed a maximum release of 99 % in 24 hours. Out of these eight formulations of EC, 1.5 % Ethylcellulose (E6) was optimized since they produced a sustained and a complete release over a period of 24 hours. Thus the knowledge on the use of ethyl cellulose to control drug release in transdermal delivery systems might be applicable to other transdermal drug delivery system as well.

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Section: Water Vapor Transmission Ratementioning

confidence: 99%

Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

John¹,

Kumar²,

Samuel³

2013

Int. Res. J. Pharm.

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“…Rosin biomaterias have excellent biocompatibility and degradation features, and film-forming ability (Fulzele et al 2003). They show potential as components in film-based drug delivery systems and dosage technology (Satturwar et al 2005;Fulzele et al 2007). …”

Section: Pine Resinmentioning

confidence: 99%

Forest Products with Health-Promoting and Medicinal Properties

Gallis¹,

Stefano²,

Moutsatsou³

et al. 2010

Forests, Trees and Human Health

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Forests are a rich renewable source of health-promoting and medicinal products. Not only the trees but also berries, nuts and mushrooms in forests contain a multitude of natural bioactive compounds which can be used in health-promoting products and medicines. In addition to the main structural components that trees contain, namely cellulose, hemicelluloses and lignin, thousands of bioactive compounds have been identified. Forest products have always had a key role in traditional medicine which continues to be of great importance, especially in developing countries. In the industrialized countries, the pharmaceutical industry is again increasingly looking at

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“…Transdermal therapeutic systems are defined as 'self contained' discrete dosage forms which, when applied to the intact skin, deliver the drug(s), through the skin, at a controlled rate to the systemic circulation 1 .Transdermal route is more convenient as compared to parenteral and oral routes, as it improve patient compliance (no pain) and avoid first pass metabolism respectively. A transdermal patch is a medicated adhesive patch that is placed above the skin to deliver a specific dose of drug through the skin with a predetermined rate of release to reach in to the systemic circulation 2 …”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Matrix Type Transdermal Patches of Pioglitazone Hydrochloride

Francis

2016

UJPR

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In present study, different transdermal patches of Pioglitazone hydrochloride were prepared using different polymers and evaluated on many parameters. Locally fabricated Franz diffusion cell was used for the in-vitro release study. Result revealed that there is a direct relationship with weight of the patch and drug content. The thickness lies in the range of 0.027 to 0.038mm. Average thickness was almost uniform within same formulation, a small variation in thickness was observed with different formulations. The weight of patches lies in the range of 43.31 to 46.3 mg. The percentage of the drug content lies in the range of 96.87 to 99.28. Content uniformity studies proved that the amount of Pioglitazone hydrochloride in each patch of 2.009 cm 2 was found to be fairly uniform. Percent moisture absorption was found to be in the range of 4.388 to 5.465, largest in formulations of batch code T3 and least in the batch code T2.The prepared transdermal drug delivery system of Pioglitazone hydrochloride using different polymers such as HPMC, EC, Chitosan and PVP had shown good promising results for all the evaluated parameters. However, for the in-vitro drug release and drug content result, formulation T4 was shown to be the optimized formulation, as higher percentage of drug release was obtained.

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Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

Cited by 39 publications

References 28 publications

Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

Formulation and Evaluation of Amlodipine Transdermal Patches Using Ethyl Cellulose

Forest Products with Health-Promoting and Medicinal Properties

Development and Evaluation of Matrix Type Transdermal Patches of Pioglitazone Hydrochloride

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