2013
DOI: 10.7150/thno.5922
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Evaluation of Polymethine Dyes as Potential Probes for Near Infrared Fluorescence Imaging of Tumors: Part - 1

Abstract: Near-infrared (NIR) organic dyes have become important for many biomedical applications, including in vivo optical imaging. Conjugation of NIR fluorescent dyes to photosensitizing molecules (photosensitizers) holds strong potential for NIR fluorescence image guided photodynamic therapy (PDT) of cancer. Therefore, we were interested in investigating the photophysical properties, in vivo tumor-affinity and fluorescence imaging potential of a series of heterocyclic polymethine dyes, which could then be conjugated… Show more

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Cited by 133 publications
(98 citation statements)
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“…Combining porphyrin-based photosensitizers with fluorophores is the original pathway to achieve wide series of theranostic conjugates [3,15,16]. In this study, we report the preparation and physicochemical characterization of the triad, in which two bacteriochlorin moieties are linked to dicarbocyanine dye as a model theranostic for fluorescence imaging and phototherapy of tumors.…”
Section: Introductionmentioning
confidence: 98%
“…Combining porphyrin-based photosensitizers with fluorophores is the original pathway to achieve wide series of theranostic conjugates [3,15,16]. In this study, we report the preparation and physicochemical characterization of the triad, in which two bacteriochlorin moieties are linked to dicarbocyanine dye as a model theranostic for fluorescence imaging and phototherapy of tumors.…”
Section: Introductionmentioning
confidence: 98%
“…¼ 805 nm) wavelengths and high molecular extinction coefficient (e ¼ 27.4 Â 10 4 M À1 cm À1 ) has been adopted so far as a non-targeting contrast agent in clinical and experimental NIR imaging and as a promising second generation photosensitizer in PDT. [36][37][38][39] However, IR-780 as many other hydrophobic cyanines can be disposed to light-induced decomposition (i.e., photobleaching) both in vitro and in vivo resulting in the loss of absorbance, fluorescence, and photoactivity, and thus possibly limiting its use in PDT. 40 In order to increase the potential of hydrophobic cyanines towards improvement of drug efficacy, its stability, and better intracellular penetration, they need to be encapsulated in nanocarriers to avoid any unexpected problems with photoactivity and to improve their dissolution performance by means of encapsulation via template-mediated processes.…”
Section: Introductionmentioning
confidence: 99%
“…79 The conjugation of IR-783 dye to photosensitizers displays strong potential for NIRF imaging-guided PDT for cancer. 38 A modified IR-783 after linking with two moieties of the photosensitizer HPPH showed perfect tumor-imaging capability and produced long-term PDT efficacy for mice bearing colon tumors. 36 Encapsulating NIRF dyes with polymers or inorganic materials to form a variety of nonmetallic nanoparticles also enhanced the photostability, biocompatibility, and fluorescence intensity of dyes with reduced self-aggregation to improve PDT efficacy.…”
Section: Photodynamic Therapymentioning
confidence: 99%
“…26 To solve these problems, a variety of structural modifications have been attempted in these dyes. 38 Acyclohexenyl ring has been introduced into the central polymethyl acetylene chain, leading to significantly increased photostability and fluorescence intensity. 39 The introduction of asulfate group not only avoided the weakening of fluorescence signals from nonspecific hydrophobic exchange of the fluorescent group in aqueous solution with other molecules but also reduced the self-aggregation of these dyes.…”
Section: Physical and Chemical Characteristics Of Near-infrared Fluormentioning
confidence: 99%
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