Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components

Ling, Wei; Dai, Tingrui; Zhang, Jingyi; Liang, Yan; Yin, Wenyue; Zhong, Balian; Jun, Zhang

doi:10.1002/cbdv.202100679

Cited by 12 publications

(4 citation statements)

References 40 publications

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“…Hesperetin has antioxidant activity. Restraining or eliminating the priming or reproduction of superfluous active substances can postpone or inhibit cell injury caused by physiological oxidants and decrease the risk of potential human health influence related to oxidative stress or free radicals [ 23 , 26 ]. It is significant to measure the antioxidant activity of hesperetin derivatives in the exploration of their potential applications in the food, pharmaceutical, or cosmetics industries.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives

et al. 2022

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Hesperetin is a class of natural products with a wide range of sources and remarkable biological activities. In this study, we described the synthesis of a series of novel hesperetin derivatives and evaluated the in vitro antioxidant and antitumor activity of these compounds. Eleven novel compounds were synthesized in moderate yields. The compounds synthesized in this work exhibited antioxidant activities against DPPH and ABTS free radicals in a dose-dependent manner. Among them, compound 3f had the best antioxidant activity, with IC50 of 1.2 μM and 24 μM for DPPH and ABTS, respectively. The antitumor activity of the compounds against human cancer cell lines, such as breast MCF-7, liver HepG2, and cervical Hela, was determined by a standard 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. Three compounds had moderate IC50 values. Interestingly, compound 3f had better biological activity than hesperetin, which matches the prediction by Maestro from Schrödinger. Therefore, the new hesperidin derivative is a promising drug for the treatment of cancer due to its effective antitumor activity. The results also suggested that the antitumor activities of hesperetin derivatives may be related to their antioxidant activities.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives

et al. 2022

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“…Each of the variables was represented by a vector, the direction and length of which indicated the contribution of variables. [43] PC1 explained 46.8 % of the variability, and was positively associated with all feature vectors but E. coli inhibition (ECI). Among them, DPPH, FRAP, TFC, ABTS and TPC had high load, indicating that the test samples in this study had the most outstanding application potential in antioxidant.…”

Section: Principal Component Analysismentioning

confidence: 99%

Leaf and Flower Extracts of Six Michelia L.: Polyphenolic Composition, Antioxidant, Antibacterial Activities and in Vitro Inhibition of α‐Amylase and α‐Glucosidase

Liao

Cao

Yang

et al. 2022

Chemistry & Biodiversity

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Methanolic extracts of the leaf and flower of Michelia L., an evergreen aromatic genus widely used in landscaping, industry and medicine of various countries, were analyzed. The UPLC-ESI-MS/MS analysis led to the identification of 28 polyphenols from six Michelia species that widely distributed and cultivated in southern China, among which quinic acid and chlorogenic acid were the main components. The flower extract of Michelia maudiae had the most abundant polyphenols content, as well as high contents of total phenolic (117.31 � 7.26 mg GAE/g DW) and total flavonoid (251.60 � 15.56 mg CE/g DW). Meanwhile, it also showed outstanding performance in three antioxidant indexes of DPPH, ABTS and FRAP. The leaf extracts of Michelia chapensis and Michelia floribunda exhibited excellent inhibition against four pathogenic bacteria. Moreover, certain inhibitory activities were displayed by Michelia macclurei extracts against α-amylase and α-glucosidase. This study explored the biological activities of six Michelia species, and provided reference for variety selection with the aim of designing novel phyto-pharmaceuticals.

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“…(2022) reported that the Majia pomelo seed oil had 39.32% lipid mainly composed of linoleic acid and oleic acid, and was not toxic to normal liver LO2 cells. In one of our previous studies, the ethyl acetate extract from pomelo seed was found to exhibit good antioxidant and herbicidal activities and contain naringin, deacetylnomilin, limonin, nomilin, and obacunone as its main components ( Ling et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Pomelo seed oil: Natural insecticide against cowpea aphid

et al. 2022

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Cowpea aphid (Aphis craccivora Koch) is a plant pest that causes serious damage to vegetable crops. Extensive use of synthetic chemical pesticides causes deleterious effects on consumers as well as the environment. Hence, the search for environmentally friendly insecticides in the management of cowpea aphids is required. The present work aims to investigate the aphicidal activity of pomelo seed oil (PSO) on cowpea aphids, the possible insecticidal mechanisms, its chemical constituent profile, as well as the toxicity of its primary compounds. The results of the toxicity assay showed that PSO had significant insecticidal activity against aphids with a 72-hour LC50 value of 0.09 μg/aphid and 3.96 mg/mL in the contact and residual toxicity assay, respectively. The enzymatic activity of both glutathione S-transferase (GST) and acetyl cholinesterase (AChE) significantly decreased, as well as the total protein content, after PSO treatment, which suggested that the reduction of AChE, GST, and the total protein content in aphids treated with PSO might be responsible for the mortality of A. craccivora. The GC-MS analysis revealed that PSO contained limonene (22.86%), (9Z,12Z)-9,12-octadecadienoic acid (20.21%), n-hexadecanoic acid (15.79%), (2E,4E)-2,4-decadienal (12.40%), and (2E,4Z)-2,4-decadienal (7.77%) as its five major compounds. Furthermore, (9Z,12Z)-9,12-octadecadienoic acid showed higher toxicity to aphids than both PSO and thiamethoxam (positive control). This study emphasized the potential of PSO as a natural plant-derived insecticide in controlling cowpea aphids and also provided a novel approach for the value-added utilization of pomelo seed.

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Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components

Cited by 12 publications

References 40 publications

Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives

Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives

Leaf and Flower Extracts of Six Michelia L.: Polyphenolic Composition, Antioxidant, Antibacterial Activities and in Vitro Inhibition of α‐Amylase and α‐Glucosidase

Pomelo seed oil: Natural insecticide against cowpea aphid

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