Evaluation of postischemic hyperemia on the skin using laser Doppler velocimetry: Study on patients with claudicatio intermittens

Guercio, R. Del; Leonardo, Giuseppe; Arpaia, M.

doi:10.1016/0026-2862(86)90066-x

Cited by 56 publications

(33 citation statements)

References 11 publications

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“…Vasomotion might not be centrally driven; however, the regulation from central controls cannot be excluded, since there are physiological stimuli that pro duce synchronized vasomotion over large portions o f the skin. Reactive hyperemia, following the occlusion o f a major arterial vessel, causes the appearance o f vigorous flow motion [11,12]. According to our stud ies, hemorrhagic shock and hypoxia also pro duce this effect.…”

Section: Physiology Of Vasomotionmentioning

confidence: 60%

Arteriolar Vasomotion: Implications for Tissue Ischemia

Intaglietta¹

1991

J Vasc Res

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Vasomotion, the rhythmical contraction and relaxation of the arterioles, is a natural property of the arteriolar microcirculation. It is observed clinically through related flow variations (flux motion) which are detected by laser Doppler flowmetry. It presents two distinct regimens: slow and fast waves, with frequencies of 1–2 and 10–20 cpm, respectively. Both activities are found in normal tissues, and their rate of incidence as well as their magnitude become significantly enhanced during abnormal conditions associated with low blood pressure and hypoperfusion. The institution of this activity by abnormal tissue conditions suggests that vasomotion is a reaction of the microcirculation aimed at improving microvascular function.

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Section: Physiology Of Vasomotionmentioning

confidence: 60%

Arteriolar Vasomotion: Implications for Tissue Ischemia

Intaglietta¹

1991

J Vasc Res

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“…During continued cooling, this vaso motor activity might be restarted by local metabolic and humoral factors in an effort to actively restart flow through the microvessels to the tissues located distally, possibly in a conflict between the depressing effects of cold and the metabolic needs of the tissues. The enhance ment of LDF cutaneous flux motion has also been demon strated in skin during the recovery phase of a postocclu sive ischemic hyperemia test [22] and in skeletal muscles during hypovolemia induced by hemorrhage [23]; this probably represents a natural property of the arteriolar Effects of Cold on Skin Microcirculation microcirculation when implicated in tissue ischemia or hypoxia [24], Although LDF and dynamic capillaroscopy measure blood flow in different compartments of the dermal vas culature [25], the point in our study where blood flux is minimal and vasomotional activity absent during cooling might correspond to the functional phenomenon of flow stop or low flow produced in human nailfold capillaries through a local cold exposure test, demonstrated by dy namic videocapillaroscopy [26,27].…”

Section: Discussionmentioning

confidence: 97%

Skin Microcirculation Responses to Severe Local Cooling

Brande¹,

Coninck²,

Lievens

1997

Int J Microcirc

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When skin is exposed to cold, cutaneous blood flow is initially restricted due to sympathetic vasoconstriction. Prolonged exposure to cold has a secondary protective vasodilator effect. In the present study, the effects of severe and prolonged local cold on the cutaneous microcirculation were assessed. In 10 young healthy subjects, laser Doppler skin flux and flux motion were measured at the calf during 20 min of local ice cooling and 15 min subsequent recovery. In the 6th minute of cooling, mean skin flux decreased to 58 ± 6% of the resting value (p < 0.05), then increased and reached 129 ± 10% of the resting value at the end of the cooling period, followed by a phase of reactive hyperemia with a maximum of 225 ± 24% (p < 0.05). Mean flux motion frequency, spontaneously present at rest with a frequency of 2.6 ± 0.2 cycles/ min decreased rapidly during the first minutes of cold exposure, was absent during the 6th to the 10th minute, reappeared and started to increase from the 11th minute and reached 4.4 ± 0.3 cycles/min during the recovery period (p < 0.05). This study seems to indicate that the phenomenon of protective increase of cutaneous microcirculatory blood flow consists of an initial phase of vasodilation, followed by a phase of active and enhanced microvessel vasomotor activity.

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“…Laser Doppler fluximetry (LDf ) is simple to use clinically and has been used quite often in patients with PAOD [47]. However, values significantly lower than normal have been recorded only in patients with critical limb ischaemia, and when the measurements have been performed on the toe pulp [47,48].…”

Section: Peripheral Arterial Obliterative Diseasementioning

confidence: 99%

“…However, values significantly lower than normal have been recorded only in patients with critical limb ischaemia, and when the measurements have been performed on the toe pulp [47,48]. In moderate and severe limb ischaemia peak reactive hyperaemia after circulatory arrest is reduced and delayed [49].…”

Section: Peripheral Arterial Obliterative Diseasementioning

confidence: 99%