Evaluation of Postprandial To Fasting Insulin Ratio as a Biochemical Marker of Insulin Resistance in Obese Indian Children

Abstract

Abbreviations: HOMA-IR, homeostasis model assessment for insulin resistance; OGTT, oral glucose tolerance test; FGIR, fasting glucose/insulin ratio; ROC, receiver operating characteristic; Ri, resistance index IntroductionObesity in children is reaching epidemic proportions and is rapidly emerging as the most important chronic disease in childhood.1 It is common knowledge that obesity is associated with an increased risk for metabolic complications, such as insulin resistance, glucose intolerance and type 2 diabetes mellitus (T2DM). Insulin resistance in adults has been shown to be a cardinal feature in the development of type 2 diabetes.2 Insulin resistance in children is the most common metabolic alteration related to obesity [3] and is significantly related to cardio metabolic risk. 4 The standard technique for assessment of insulin sensitivity is the hyperinsulinemic euglycemic clamp. Although recognised as the ultimate gold standard, it is too invasive, cumbersome and expensive for epidemiological or routine clinical use. On the other hand the oral glucose tolerance test (OGTT) is better suited for assessment of large populations as it is relatively non invasive, a minimal risk procedure and practical for office setting. AbstractBackground: Insulin resistance in childhood obesity is a well recognised and worrisome

Study of Markers for Assessment of Insulin Resistance in Obese Children and Adolescents

“…glucose tolerance test utilizing the minimal model. However, both these tests are not easily accomplished, are time consuming, expensive and invasive [7].…”