Evaluation of Potential Effect of Menthol Solution on Oral Hygiene Status of Dental Students in a University in Iraq

Ali, Nidhal A.; Abbas, Maha Jamal; Al-Bayaty, Fouad Hussain M.H

doi:10.4314/tjpr.v14i4.18

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…With respect to the oral cavity, 20 mM menthol was reported to reduce lingual heat pain in humans, although this is in contrast to another report on enhanced warm sensation by such a high, irritant, menthol concentration (Green, 1985;Albin et al, 2008). Commercial mouthwashes contain 30 mM and higher menthol concentrations (Ali et al, 2015). In our hands, the irritant, CGRP-releasing action of nicotine (20 mM, pH 9), activating TRPA1 and TRPV1, was not influenced by 20 mM menthol.…”

Section: Discussioncontrasting

confidence: 99%

The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa

Kichko

Neuhuber

Kobal

et al. 2018

Eur J of Neuroscience

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Spices in food and beverages and compounds in tobacco smoke interact with sensory irritant receptors of the transient receptor potential (TRP) cation channel family. TRPV1 (vanilloid type 1), TRPA1 (ankyrin 1) and TRPM8 (melastatin 8) not only elicit action potential signaling through trigeminal nerves, eventually evoking pungent or cooling sensations, but by their calcium conductance they also stimulate the release of calcitonin gene-related peptide (CGRP). This is measured as an index of neuronal activation to elucidate the chemo- and thermosensory transduction in the isolated mouse buccal mucosa of wild types and pertinent knockouts. We found that the lipophilic capsaicin, mustard oil and menthol effectively get access to the nerve endings below the multilayered squamous epithelium, while cigarette smoke and its gaseous phase were weakly effective releasing CGRP. The hydrophilic nicotine was ineffective unless applied unprotonated in alkaline (pH9) solution, activating TRPA1 and TRPV1. Also, mustard oil activated both these irritant receptors in millimolar but only TRPA1 in micromolar concentrations; in combination (1 mm) with heat (45 °C), it showed supraadditive, that is heat sensitizing, effects in TRPV1 and TRPA1 knockouts, suggesting action on an unknown heat-activated channel and mustard oil receptor. Menthol caused little CGRP release by itself, but in subliminal concentration (2 mm), it enabled a robust cold response that was absent in TRPM8 but retained in TRPA1 and strongly reduced by TRPM8 inhibitors. In conclusion, all three relevant irritant receptors are functionally expressed in the oral mucosa and play their specific roles in inducing neurogenic inflammation and sensitization to heat and cold.

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Section: Discussioncontrasting

confidence: 99%

The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa

Kichko

Neuhuber

Kobal

et al. 2018

Eur J of Neuroscience

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“…The results were in agreement with studies conducted among adults on clinical parameters like means of plaque, bleeding and gingival indices scores were recorded on baseline examination and after the period of rinse by Nidhal Ali et al and they observed that a significant reduction in clinical parameters scores after the use of menthol extract mouthrinse as compared to the use of the CHX group. 9 Few more authors like Shetty PR et al, and Pistorius A et al were also identified that there will be a reduction in gingival inflammation after the use of the herbal extract. 12,13 The difference noted in the mean score reduction of gingival index and plaque index at the follow-up between the menthol group and chlorhexidine group was statistically significant (p= 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Both types of mouthwash were coded and looked similar to avoid bias. 9 All of the subjects were advised to keep brushing their teeth as usual, and the assigned mouth rinses were given to the subjects in their respective groups. Depending upon group, subjects were asked to rinse their mouth with 10 mL of menthol mouth rinse twice a day, around 2 to 5 minutes after brushing for 14 days.…”

Section: Preparation Of Menthol Mouth Rinsementioning

confidence: 99%

Eff ectiveness of Menthol and Chlorhexidine Mouth Rinses on Reduction of Plaque, Gingivitis, and Streptococcus mutans Count in Saliva

Doddawad¹,

Jose²,

Shivananda³

et al. 2023

IJPQA

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Introduction: Menthol is a new product made from mint that is the most eff ective approach to avoid infections. There has been little human research on using menthol as a mouth rinse ingredient, and there is little information on the subject. Aim: This study aimed to know the eff ectiveness of menthol and chlorhexidine mouth rinses in reducing plaque, gingivitis, and Streptococcus mutans in saliva among 21 to 45 years old subjects. Material and method: The study is a placebo-control, parallel-group blind randomized clinical trial consisting of a 2-week period. Forty subjects were selected and randomized into 2 groups consisting of 20 subjects: group A (menthol) and group B (chlorohexidine). The subjects were clinically examined for plaque accumulation using the plaque index (Turesky et al.) and gingival infl ammation using the gingival index (loe and silness). The saliva samples were collected for estimation of S. mutans count on the fi rst day of baseline and after the 14th day using an assigned mouth rinse. Results: Menthol mouth rinse showed lower scores in plaque index, gingival index, and S. mutans count compared to the chlorhexidine mouth rinse which was statistically signifi cant (p = 0.05). Mouth rinse with menthol is better compared to mouth rinse with chlorohexidine. Conclusion: Menthol mouthwash has therapeutic potential and can be prescribed by a dentist as part of routine oral hygiene practice

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“…The different herbal ingredients used in preparing this tooth paste have reported to have beneficial effects in treating the problems mentioned above. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Minerals which are used in this formulation are having different properties like citric acid has cleansing effect and whitening of teeth, [31] alum is for whitening and gum disease, [32] salt is for anti-bacterial effect and for cleansing, [33] and zinc chloride is to reduce enamel solubility. [34] Hence, herbomineral tooth paste possess many benefits, being natural and maintaining individual oral health, when compared to the non herbomineral toothpaste.…”

Section: Original Articlementioning

confidence: 99%

Untitled

2022

AJP

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Background:The demand for a broad spectrum antimicrobial toothpaste is highly desirable to reduce, control, and prevent various types of dental diseases. Therefore, research into the production of herbal toothpaste to suppress the incidence of dental diseases is pertinent. Plant-based tooth paste has proved to be best at treating the gingivitis and other oral problems. Aim: In the present study, the herbomineral tooth paste was prepared using 18 different herbal ingredients which possess different uses both internally and externally and also four mineral salts that help to avoid tooth decay and gingival inflammation. The formulated toothpaste was evaluated for physicochemical properties and anti-bacterial activity. Methodology: Three different formulations were prepared and evaluated for various physicochemical properties such as stability, pH, homogeneity, compatibility with toothpaste packaging material, spreadability, abrasiveness, foaming ability, cleaning ability, and anti-bacterial activity that was tested on two bacteria, Staphylococcus aureus strain (MTCC 96) and Streptococcus mutans strain (MTCC 890) in comparison with commercial formulation, Vicco Vajradanth. Results: All the results of evaluated parameters showed that experimental formulation (F3) was comparably equal and better when compared with commercial formulation in terms of standards specified by the Bureau of Indian Standards 6356-1993 and found to be of good quality. The results were analyzed using two-way ANOVA. The results of the formulations are promising when compared to a commercial tooth paste. Conclusion: This formulation prevented the growth of S. mutans and S. aureus, organisms causing dental caries. This formulation maintains oral hygiene thereby preventing gingivitis and dental caries.

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Evaluation of Potential Effect of Menthol Solution on Oral Hygiene Status of Dental Students in a University in Iraq

Cited by 8 publications

References 15 publications

The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa

The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa

Eff ectiveness of Menthol and Chlorhexidine Mouth Rinses on Reduction of Plaque, Gingivitis, and Streptococcus mutans Count in Saliva

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